导师代码： 10471
导师姓名： 刘贻尧
性别： 男
特称： 教育部新世纪优秀人才

职称： 教授
学位： 工学博士学位
属性： 专职
电子邮件： liuyiyao@hotmail.com

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学术经历： 1994/09-1998/07重庆大学材料科学与工程学院，材料工程，学士； 1998/09-2001/07重庆大学生物工程学院，生物医学工程，硕士； 2001/09-2004/09日本群马大学生物化学工程系，生物物理，博士； 2004/09-2008/06电子科技大学生命科学与技术学院，副教授； 2005/12-2007/09日本德岛大学医学部，博士后； 2008/07-至今电子科技大学生命科学与技术学院，教授/博士生导师；2014/07-2014/08德国卡尔斯鲁厄理工学院(KIT)，高级访问****； 2009/12-至今电子科技大学生命科学与技术学院，副院长

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个人简介： 教育部新世纪优秀人才计划和四川省****基金入选者。主要从事肿瘤细胞力学、肿瘤微环境-肿瘤细胞相互作用及其细胞信号转导、纳米医学等相关交叉学科的研究，深入开展肿瘤微环境物化特性对肿瘤细胞粘附、迁移与运动的影响规律及其调控的力学-生物学耦合机制，探讨其信号转导网络与途径，寻找分子靶标；开展新型微纳生物材料在基因/药物靶向输送、分子/细胞成像中的应用研究，制备了几种了靶向诊疗一体化的新型纳米载体复合物，并深入研究纳米复合物与靶细胞间的相互作用规律。上述研究对深刻理解肿瘤转移的分子机制及其相关药物的开发、早期诊断与成像有重要意义。主持了包括国家自然科学基金，教育部新世纪优秀人才项目，四川省青年科技基金等多项课题。迄今已在生物医学主流期刊Biotechnology Advances、Journal of Controlled Release、Oncotarget、Cancer Letters、ACS Applied Materials & Interfaces、Scientific Reports、International Journal of Cancer、British Journal of Pharmacology等发表SCI论文50余篇，SCI他引次数800余次，申请/授权发明专利6项，不定期担任Advanced Functional Materials, Journal of Controlled Release, Biomaterials, Journal of Cellular and Molecular Medicine，Small，Drug Discovery Today，JACS等国际杂志的审稿人，现任中国生物力学与生物流变学专业委员会委员，中国生物力学专业委员会委员，中国病理生理学会中国动脉粥样硬化专业委员会委员，四川省生物医学工程学会理事，四川省华人华侨专业人才理事会副会长，《World Journal of Radiology》编委，《Journal of Developmental Biology and Tissue Engineering》编委，《Chinese Journal of Biology》编委，《中国组织工程研究》编委，《医用生物力学》编委。2009年入选教育部新世纪优秀人才支持计划，2010年入选四川省****学术技术带头人培育计划，同年被评为电子科技大学“十一五”科研先进工作者，2011年入选四川省学术技术带头人后备人选和电子科技大学“****”，2013年入选四川省有突出贡献的专家，2014年入选四川省****基金。

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科研项目： 1. 小窝蛋白-1在肿瘤细胞抗失巢凋亡力学信号转导中的功能与调控机制研究，国家自然科学基金(no.**)； 2. 剪切力调控肿瘤细胞粘附与迁移新机制：整合素alpha(v)beta(3)和GP IIb/IIIa作用规律及其力学生物学机制研究，国家自然科学基金(no. **)； 3. 生物－磁双重靶向Fe3O4@SiO2纳米荧光探针制备及其生物医学应用初步研究，国家自然科学基金(no.**)； 4. 剪切流场下靶向抗-VCAM-1超声微泡在内皮细胞上的粘附规律及其在动脉粥样硬化检测中的应用，国家自然科学基金(no. **)； 5. 多功能化荧光纳米探针的构建及其在心血管疾病早期诊断中的应用基础研究，教育部新世纪优秀人才支持计划(no. NCET-09-0263)； 6. 基因与化疗药物共输送的PLGA超声纳米泡的构建及其协同抗肿瘤作用与超声成像规律研究，四川省****基金(no.2014JQ0008)

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研究成果： 发表SCI论文50余篇，主要论文如下：（*通讯作者）01. Li S, Lu J, Chen Y, Xiong N, Li L, Zhang J, Yang H, Wu C, Zeng H, Liu Y*. (2016) MCP-1-triggered ERK/GSK-3beta/Snail pathway facilitates epithelial- mesenchymal transition and promotes cell migration of human breast carcinoma MCF-7 cells. Cellular and Molecular Immunology. doi:10.1038/cmi.2015.10602. Li L, Zhang J, Xiong N, Li S, Chen Y, Yang H, Wu C, Zeng H, Liu Y*. (2016) Notch-1 signaling activates NF-?B in human breast carcinoma MDA-MB-231 cells via PP2A-dependent PI3K/AKT pathway. Medical Oncology. 33(4), 1-1103. Yang H, Guan L, Li S, Jiang Y, Xiong N, Li L, Wu C, Zeng H, Liu Y*. (2016) Mechanosensitive caveolin-1 activation-induced PI3K/Akt/mTOR signaling pathway promotes breast cancer motility, invadopodia formation and metastasis in vivo. Oncotarget. DOI: 10.18632/oncotarget.758304. Wu M, Li T, Chen L, Peng S, Liao W, Bai R, Zhao X, Yang H, Wu C, Zeng H, Liu Y*. (2016) Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms. Journal of Ethnopharmacology. 180: 18-27. 05. Wu C, Zhu A, Li D, Wang L, Yang H, Zeng H, Liu Y*. (2016) Photosensitizer-assembled PEGylated graphene-copper sulfide nanohybrids as a synergistic near-infrared phototherapeutic agent. Expert Opinion on Drug Delivery. 13: 155-165. 06. Yang H, Deng L, Li T, Shen X, Yan J, Zuo L, Wu C, Liu Y*. (2015) Multifunctional PLGA nanobubbles as theranostic agents: Combining doxorubicin and P-gp siRNA co-delivery into human breast cancer cells and ultrasound cellular imaging. Journal of Biomedical Nanotechnology. 11: 2124-2136. 07. Li S, Zhang J, Yang H, Wu C, Dong X, Liu Y*. (2015) Copper depletion inhibits CoCl2-induced aggressive phenotype of MCF-7 cells via downregulation of HIF-1 and inhibition of Snail/Twist-mediated epithelial-mesenchymal transition. Scientific Reports. 5: 12410; DOI: 10.1038/srep12410. 08. Zeng H, Agyapong D.A.Y, Li C, Zhao R, Yang H, Wu C, Jiang Y, Liu Y*. (2015) A carcinoembryonic antigen optoelectronic immunosensor based on thiol-derivative-nanogold labeled anti-CEA antibody nanomaterial and gold modified ITO. Sensors & Actuators B: Chemical. 221: 22-27. 09. Li T, Shen X, Chen Y, Zhang C, Yan J, Yang H, Wu C, Zeng H, Liu Y*. (2015) Polyetherimide-grafted Fe3O4@SiO2 nanoparticles as theranostic agents for simultaneous VEGF siRNA delivery and MR imaging. International Journal of Nanomedicine. 10: 4279-4291.10. Wu C, He Q, Zhu A, Li D, Xu M, Yang H, Liu Y*. (2014) Synergistic anticancer activity of photo- and chemo-responsive nanoformulation based on polylysine-functionalized graphene. ACS Applied Materials & Interfaces. 6(23): 21615-21623.11. Yang H, Li Y, Li T, Xu M, Chen Y, Wu C, Liu Y*. (2014) Multifunctional core/shell nanoparticles cross-linked polyetherimide-folic acid as efficient Notch-1 siRNA carrier for targeted killing of breast cancer. Scientific Reports. 4: 7072; DOI: 10.1038/srep07072.12. Li L, Zhao F, Lu J, Li T, Yang H, Wu C, Liu Y*. (2014) Notch-1 signaling promotes the malignant features of human breast cancer through NF-kB activation. PLoS ONE. 9(4): e95912. 13. Zhao F, Li L, Guan L, Yang H, Wu C, Liu Y*. (2014) Roles of GP IIb/IIIa and alpha(v)beta(3) integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. Cancer Letters. 344: 62-73. 14. Yang H, Zhao F, Li Y, Xu M, Li L, Wu C, Miyoshi H, Liu Y*. (2013) VCAM-1-targeted core/shell nanoparticles for selective adhesion and delivery to endothelial cells with lipopolysaccharide-induced inflammation under shear flow and cellular magnetic resonance imaging in vitro. International Journal of Nanomedicine. 8: 1897-1906. 15. Liu Y*, Shi M, Xu M, Yang H, Wu C. (2012) Multifunctional nanoparticles of Fe3O4@SiO2(FITC)/PAH conjugated the recombinant plasmid of pIRSE2-EGFP/VEGF165 with dual functions for gene delivery and cellular imaging. Expert Opinion on Drug Delivery. 9(10): 1197-1207.16. Yang H, Zhang L, Xiong X, Liu Y*. (2011) Specific adhesion and accumulation of VCAM-1-targeted ultrasound microbubbles to inflammatory endothelial cells under hemodynamic shear flow simulation. Journal of Controlled Release. 152(s1): e227-e229. 17. Shi M, Liu Y*, Xu M, Yang H, Wu C, Miyoshi H. (2011) Core/shell Fe3O4@SiO2 nanoparticles modified with PAH as a vector for EGFP plasmid DNA delivery into HeLa cells. Macromolecular Bioscience. 11: 1563-1569. 18. Yang H, Lou C, Xu M, Wu C, Miyoshi H, Liu Y*. (2011) Investigation of folate conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism. International Journal of Nanomedicine. 6: 2023-2032. 19. Yang H, Xiong X, Zhang L, Wu C, Liu Y*. (2011) Adhesion of bio-functionalized ultrasound microbubbles to endothelial cells by targeting to vascular cell adhesion molecule-1 under shear flow. International Journal of Nanomedicine. 6: 2043-2051. 20. Liu Y*, Lou C, Yang H, Shi M, Miyoshi H. (2011) Silica nanoparticles as potential drug/gene delivery carriers and fluorescent nano-probes: recent advances. Current Cancer Drug Targets. 11: 156-163. 21. Xiong X, Zhao F, Shi M, Yang H, Liu Y*. (2011) Polymeric microbubbles for ultrasonic molecular imaging and targeted therapeutics. Journal of Biomaterials Science-Polymer Edition. 22: 417-428.22. Meng G, Liu Y*, Lou C, Yang H. (2010) Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-kappaB activation by disrupting lipid rafts in CD14-negative endothelial cells. British Journal of Pharmacology. 161: 1628-1644. 23. Liu Y*, Zhao F, Gu W, Yang HS, Meng Q, Zhang Y, Yang H, Duan Q. (2009) The Roles of Platelet GPIIb/IIIa and alpha(v)beta(3) integrins during HeLa cells adhesion, migration, and invasion to monolayer endothelium under static and dynamic shear flow. Journal of Biomedicine and Biotechnology. doi:10.1155/2009/829243. 24. Liu Y*, Miyoshi H. (2008) Preparation and characterization of novel drug delivery system of light-sensitive silica nanocapsules with thin shells. Journal of Biomedical Nanotechnology. 4: 25-32. 25. Guo Z, Cai SX, Fang R, Chen H, Du J, Tan Y, Ma W, Hu H, Cai SH, Liu Y*. (2007) The synergistic effects of CXCR4 and EGFR on promoting EGF-mediated metastasis in ovarian cancer cells. Colloids and Surfaces B: Biointerfaces. 60: 1-6.26. Liu Y*, Miyoshi H, Nakamura M. (2007) Nanomedicine for drug delivery and imaging: a promising avenue for cancer therapy and diagnosis by targeted functional nanoparticles. International Journal of Cancer. 120: 2527-2537. 27. Liu Y*, Miyoshi H, Nakamura M. (2007) Novel drug delivery system of hollow mesoporous silica nanocapsules with thin shells: Preparation and fluorescein isothiocyanate (FITC) release kinetics. Colloids and Surfaces B: Biointerfaces. 58: 180-187.28. Liu Y,* Miyoshi H, Nakamura M. (2006) Encapsulated ultrasound microbubbles: therapeutic application in drug/gene delivery. Journal of Controlled Release. 114: 89-99. 29. Liu Y*, Yang H, Sakanishi A. (2006) Ultrasound: mechanical gene transfer into plant cells by sonoporation. Biotechnology Advances. 24: 1-16. 30. Liu Y, Uno H, Takatsuki H, Sakanishi A. (2005) Interrelation between HeLa-S3 cell transfection and hemolysis in red blood cell suspension using pulsed ultrasound of various duty cycles. European Biophysics Journal with Biophysics Letters. 34:163-169.

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专业研究方向： 专业名称 研究方向 招生类别
083100生物医学工程 09细胞生物学 博士
071000生物学 04细胞生物学 硕士
083100生物医学工程 08电子科技大学-加拿大麦吉尔大学生物医学工程-神经科学双硕士教育项目 硕士

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