导师代码： 12488
导师姓名： 王贝贝
性别： 女
特称：

职称： 副教授
学位： 理学博士学位
属性： 专职
电子邮件： bbwang@uestc.edu.cn

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学术经历： 2017.11 – 至今 电子科技大学 副教授2015.05 – 2017.11 卡尔加里大学 博士后 导师：Dr. Peter Tieleman2012.07 - 2015.05 密歇根州立大学 访问****、博士后 导师：Dr. Michael Feig

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个人简介： 2007.09-2012.07 复旦大学 博士 导师：王文宁教授 2003.09-2007.07 中国石油大学 （北京） 学士

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科研项目： We study biology from molecular to cellular scales to bridge between microscopic and macroscopic phenomena using a variety of computational methods. We create state-of-the-art computational models of lipids, DNA, RNA and proteins to study their structures and dynamics.1) Building the computational models of the complicated structure of the cell wall;2) Simulating the electrospray ionization (ESI) process of membrane protein systems;3) The structure-dynamics-function relationships of the DNA replication and DNA-RNA transcription processes.

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研究成果： (15) 伍克煜，刘峰江，许浩，张浩天，王贝贝*. 合成生物学基因设计软件：iGEM设计综述。生物信息学,2020,18(1):8-15。(14)Ting Wang, Ying Shen, Yuanyuan Li, Beibei Wang, Benfang Wang, Depei Wu, Changgeng Ruan, Yiqiang Wang*. Ectopic ATP Synthase Β Subunit Proteins On Human Leukemia Cell Surface Interact With Platelets By Binding Glycoprotein IIb. Haematologica. 2019 104, e364-e368.(13) Beibei Wang, Rachel E. Sexton, Michael Feig*. Kinetics of nucleotide entry into RNA polymerase active site provides mechanism for efficiency and fidelity. BBA Gene Regulatory Mechanisms 2017 1860, 482-490. (12) Beibei Wang, Joshua Francis, Monika Sharma, Sean M. Law, Alexander V. Predeus, Michael Feig*. Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication Pathways. PLoS Comput. Biol. 2016 12(10): e**. (11) Mark Farrugia, Beibei Wang, Michael Feig, Robert P. Hausinger*. Mutational and Computational Evidence That a Nickel-Transfer Tunnel in UreD Is Used for Activation of Klebsiella aerogenes Urease. Biochemistry 2015, 54, 6392-6401. (10) Zhicheng Zuo, Beibei Wang, Jingwei Weng, Wenning Wang*. Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB. Sci. Rep. 2015, 5, 13905. (9) Beibei Wang, Jingwei Weng, Wenning Wang*. Substrate binding accelerates the conformational transition and substrate extrusion in multidrug efflux transporter AcrB. Front. Microbiol. 2015, 6, 302. (8) Beibei Wang, Kristopher Opron, Zachary F. Burton, Robert I. Cukier, Michael Feig*. Five checkpoints maintaining the fidelity of transcription by RNA polymerases in structural and energetic details. Nucleic Acid Res. 2015, 43, 1133-1146.(7) Beibei Wang, Jingwei Weng, Wenning Wang*. Free Energy Profiles of Ion Permeation and Doxorubicin Translocation in TolC. J. Theor. Comput. Chem. 2014, 13, **. (6) Beibei Wang, Jingwei Weng, Wenning Wang*. Multiple conformational states and gate opening of outer membrane protein TolC revealed by MD simulations. Proteins, 2014, 82, 2169-2179.(5) Beibei Wang, Michael Feig, Robert I. Cukier, Zachary F. Burton*. Computational simulation strategies for analysis of multi-subunit RNA polymerases. Chem. Rev. 2013, 113, 8546-8566. (4) Beibei Wang, Alexander V. Predeus, Zachary F. Burton, Michael Feig*. Energetic and Structural Details of the Trigger-Loop Closing Transition in RNA Polymerase II. Biophys. J. 2013, 105, 767-775. (3) Mingming Zhang, Beibei Wang, Tao Jiang, Meijuan Jiang, Tao Yi*. From nano ribbon to fibre by concentration control. Cryst. Eng. Comm. 2012, 14, 8057–8062. (2) Beibei Wang, Jingwei Weng, Kangnian Fan, Wenning Wang*. Inter-domain flexibility and pH-induced conformational changes of AcrA revealed by molecular dynamics simulations. J. Phys. Chem. B, 2012, 116, 3411-3420.(1) Beibei Wang, Jingwei Weng, Kangnian Fan, Wenning Wang*. Elastic network model-based normal mode analysis reveals the conformational couplings in the tripartite AcrAB-TolC multidrug efflux complex. Proteins, 2011, 79, 2936-2945.

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专业研究方向： 专业名称 研究方向 招生类别
071000生物学 02生物物理学 硕士
083100生物医学工程 08电子科技大学-加拿大麦吉尔大学生物医学工程-神经科学双硕士教育项目 硕士

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