今天是：2015年12月20日 星期日 农历十一月初十
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药物化学系
药剂学系
天然药物学系
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临床药学与药事管理学系
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高会乐（硕士生导师）

作者：佚名来源：发布时间：2011年12月29日点击/评论：3980/0
单位：四川大学华西药学院药剂学系

通讯地址：成都市人民南路三段17号四川大学华西药学院药学大楼609室

E-mail:gaohuile@scu.edu.cn
简历

2004.09-2008.07复旦大学药学院，获理学学士学位

2008.09-2013.06 复旦大学药学院，获药剂学博士学位

2013.07-2014.06四川大学华西药学院药剂系讲师

2014.07至今 四川大学华西药学院药剂系副教授、硕导

2015.10-2016.10 斯坦福大学医学院访问学者
研究方向

1、新型脑靶向递药系统的构建和评价；

2、基于荧光碳量子点的纳米递药系统的设计、表征及应用；

3、具有环境敏感性的纳米递药系统及其材料的设计、合成和评价
主要承担课题

1、国家自然科学基金面上项目，“基于生物点击化学的肿瘤微环境响应性纳米载体的肿瘤靶向递药研究”，**，实施年限：2016.01.01-2019.12.31，主持。

2、国家自然科学基金青年项目，“基于粒径智能调节、具有肿瘤微环境响应的脑转移瘤靶向递药系统研究”，**，实施年限：2015.01.01-2017.12.31，主持。

3、四川大学优秀青年基金项目，“基于生物点击化学的肿瘤微环境响应性纳米载体的肿瘤靶向递药研究”，2015SCU04A14，实施年限：2015.1-2017.12，主持。

4、四川大学-泸州市人民政府战略合作科技项目，“（川大-泸州）替莫唑胺胶囊的研制与研发”，2013CDLZ-S14，实施年限2014.01.01-2015.12.31，主持。

5、四川大学青年教师科研启动基金，“靶向分子对纳米系统与血浆蛋白相互作用及靶向性的影响”，2014SCU11044，实施年限：2014.01.01-2015.12.31，主持。
获得荣誉：

1、2015年10月获中国药学会中恒青年药剂学奖

2、2015年04月博士论文获上海市优秀博士论文

3、2014年12月获四川大学青年骨干教师称号
研究论文：

1、Zheng M, Ruan S, Liu S, Sun T, Qu D, Zhao H, Xie Z*, Gao H*, Jing X, Sun Z*. Self-targeting fluorescent carbon dots for diagnosis of brain cancer cells. ACS Nano. 2015. (IF=12.881)

2、Ruan S, Cao X, Cun X, Hu G, Zhou Y, Zhang Y, Lu L, He Q, Gao H*. Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release. Biomaterials. 2015, 60: 100-110.(IF=8.557)

3、Ruan S, Yuan M, Zhang L, Hu G, Chen J, Cun X, Zhang Q, Yang Y, He Q*, Gao H*. Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles. Biomaterials. 2015, 37:425-435.(IF=8.557)

4、Ruan S, He Q, Gao H*. Matrix metalloproteinase triggered size-shrinkable gelatin-gold fabricated nanoparticles for tumor microenvironment sensitive penetration and diagnosis of glioma. Nanoscale. 2015, 7(21): 9487-9496.(IF=7.394)

5、Hu G, Cun X, Wang Y, He Q, Gao H*. Peptide mediated active targeting and intelligent particle size reduction-mediated enhanced penetrating of fabricated nanoparticles for triple-negative breast cancer treatment. Oncotarget, 2015. (IF=6.359)

6、Ruan S, Chen J, Cun X, Long Y, Tang J, Qian J, Shen S, Jiang X, Zhu J, He Q*, Gao H*. Noninvasive in vivo diagnosis of brain gliomas using RGD-decorated fluorescent carbonaceous nanospheres. J Biomed Nanotech, 2015, 11(12): 2148-2157. (IF=5.338)

7、Gao H, Cao S, Yang Z, Zhang S, Pang Z, Jiang X. Preparation, characterization and anti-glioma effects of docetaxel-loaded, lipoprotein-like nanoparticles. J Biomed Nanotech. 2015.11(12):2137-2147. (IF=5.338)

8、Hu G, Wang Y, He Q*, Gao H*.Multistage drug delivery system based on microenvironment-responsive dendrimer-gelatin nanoparticles for deep tumor penetration.RSC Adv.2015, 5: 85933-85937. (IF=3.84)

9、Ruan S, Zhang L, Chen J, Cao T, Yang Y, Liu Y, He Q, Gao F*, Gao H*. Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer. RSC Adv.2015, 5:64303 - 64317. (IF=3.84)

10、Chen J, Cun X, Ruan S, Wang Y, Zhang Y, He Q*, Gao H*. Glioma cell targeting doxorubicin delivery and redox-responsive release using angiopep-2 decorated carbonaceous nanodots.RSC Adv.2015, 5: 57045 - 57049. (IF=3.84)

11、Chen J, Sun H, Ruan S, Wang Y, Shen S, Xu W, He Q, Gao H*. In vitro and in vivo toxicology of bare and PEGylated fluorescent carbonaceous nanodots in mice and zebrafish: the potential relation with autophagy.RSC Adv.2015, 5: 38547-38557. (IF=3.84)

12、Ruan S, Qian J, Shen S, Chen J, Cun X, Zhu J, Jiang X, He Q*, Gao H*. Non-invasive imaging of breast cancer using RGDyK functionalized fluorescent carbonaceous nanospheres. RSC Adv.2015, 5: 25428-25436. (IF=3.84)

13、Gao H*, Zhang Q, Yang Y, Jiang X, He Q*. Tumor homing cell penetrating peptide decorated nanoparticles used for enhanced tumor targeting delivery and therapy. Int J Pharm. 2015, 478: 240-250.(IF=3.65)

14、Chen J, Sun H, Wang W, Xu W, He Q, Shen S, Qian J*, Gao H*.Polyethylene glycol modification reduces the cardiac toxicity of carbonaceous dots in mice and zebrafish model.Acta Pharmacol Sin. 2015.(IF=2.912)

15、Gao H, Yang Z, Cao S, Xiong Y, Zhang S, Pang Z, Jiang X. Tumor cells and neovasculature dual targeting delivery for glioblastoma treatment. Biomaterials. 2014, 35(7): 2374-2382.(IF=8.557)(C级)

16、Ruan S, Qian J, Shen S, Zhu J, Jiang X, He Q, Gao H*. A simple one-step method to prepare fluorescent carbon dots and their potential application in non-invasive glioma imaging.Nanoscale. 2014, 6(17): 10040-10047.(IF=7.394)

17、Gao H, Yang Z, Zhang S, Pang Z, Liu Q, Jiang X. Study of the pharmacology mechanisms of dual targeting drug delivery system with tumor microenvironment assays. Acta Biomateria. 2014, 10(2): 858-867.(IF=6.025)高被引论文

18、Gao H, Hu G, Zhang Q, Zhang S, Jiang X, He Q. Pretreatment with chemotherapeutics for enhanced nanoparticles accumulation in tumor: the potential role of G2 cycle retention effect.Sci Rep. 2014,4: 4492.(IF=5.578)

19、Ruan S, Qian J, Shen S, Chen J, Zhu J, Jiang X, He Q*, Yang W*, Gao H*. Near-infrared fluorescent carbonaceous nanodots for glioma imaging after angiopep-2 decoration. Bioconjug Chem. 2014, 25: 2252-2259.(IF=4.513)

20、Ruan S, Wan J, Fu Y, Han K, Li X, Chen J, Zhang Q, Shen S, He Q, Gao H*.PEGylated fluorescent carbon nanoparticles for noninvasive heart imaging. Bioconjug Chem. 2014,25(6): 1061-1068.(IF=4.513)

21、Gao H, Zhang S, Cao S, Yang Z,Pang Z, Jiang X. Angiopep-2 and activatable cell penetrating peptide dual-functionalized nanoparticles for systemic glioma targeted delivery.Mol Pharm. 2014, 11(8): 2755-2763. (IF=4.384)

22、Gao H, Xiong Y, Zhang S, Yang Z, Cao S, Jiang X. RGD and interleukin-13 peptide functionalized nanoparticles for enhanced glioblastoma cells and neovasculature dual targeting delivery and elevated tumor penetration. Mol Pharm. 2014,11(3): 1042-1052. (IF=4.384)(D级)

23、Mei L, Zhang Q, Yang Y, He Q, Gao H*. Angiopep-2 and activatable cell penetrating peptide dual modified nanoparticles for enhanced tumor targeting and penetrating. Int J Pharm. 2014, 474: 95-102.(IF=3.65)

24、Gao H, Zhang S, Yang Z, Cao S, Jiang X, Pang Z. In vitro and in vivo intracellular distribution and anti-glioblastoma effects of docetaxel-loaded nanoparticles functioned with IL-13 peptide.Int J Pharm. 2014, 466(1-2): 8-17.(IF=3.65)(D级)

25、Gao H, Wang Y, Chen C, Chen J, Wei Y, Cao S, Jiang X. Incorporation of lapatinib into core-shell nanoparticles improves both the solubility and anti-glioma effects of the drug. Int J Pharm. 2014; 461(1-2): 478– 488.(IF=3.65)(D级)

26、Qian J, Ruan S, Cao X, Cun X, Chen J, Shen S, Jiang X, He Q, Zhu J*, Gao H*. Fluorescent carbonaceous nanospheres as biological probe for noninvasive brain imaging. JColloid Interf Sci. 2014, 436: 227-233.(IF=3.368)

27、Qian J, Chen J, Ruan S, Shen S, He Q, Jiang X, Zhu J*, Gao H*. Preparation and biological evaluation of photoluminescent carbonaceous nanospheres.JColloid Interf Sci. 2014, 429: 77-82.(IF=3.368)(D级)

28、Ruan S, Zhu B, Zhang H, Chen J, Shen S, Qian J, He Q, Gao H*. A simple one-step method for preparation of fluorescent carbon nanospheres and the potential application in cell organelles imaging. JColloid Interf Sci. 2014,422: 25-29.(IF=3.368)(D级)

29、Gao H, Yang Z, Zhang S, Pang Z, Jiang X. Internalization and subcellular fate of aptamer and peptide dual-functioned nanoparticles. J Drug Target.2014, 22(5): 450-459.(IF=2.741)(D级)

30、Zhang L, Zhang S, Ruan S, Zhang Q, He Q, Gao H*. Lapatinib incorporated lipoprotein-like nanoparticles: preparation and breast cancer targeting mechanism. Acta Pharmacol Sin. 2014,35(6): 846-852.(IF=2.912)(E级)

31、Gao H, Yang Z, Zhang S, Cao S, Pang Z, Yang X, Jiang X.Glioma-homing peptide with a cell-penetrating effect for targeting delivery with enhanced glioma localization, penetration and suppression of glioma growth. J Control Release.2013, 172(3):921-928. (IF=7.261)(C级)

32、Gao H, Cao S, Chen C,Cao S, Yang Z, Xi Z, Pan S, Zhang Q, Jiang X. Incorporation of lapatinib into lipoprotein-like nanoparticles with enhanced water solubility and anti-breast cancer effect. Nanomedicine (Lond).2013, 8(9): 1429-1442. (IF=5.824)(D级)

33、Gao H, Yang Z, Zhang S, Cao S, Pang Z, Jiang X. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep. 2013, 3: 2534.(IF=5.078)

34、Gao H, Hu Y, Xiong Y, Zhang S, Yang J, Yu L, Jiang X. Glioma targeting and anti-glioma effect of interleukin 13 peptide and RGD peptide dual functionalized nanoparticles.Curr Pharm Biotechnol. 2013, 14: 1118-1126.(IF=2.511)

35、Gao H, Chen C, Xi Z, Chen J, Zhang Q, Cao S, Jiang X. In Vivo Behavior and Safety of Lapatinib-Incorporated Lipid Nanoparticles. Curr Pharm Biotechnol. 2013, 14: 1062-1071.(IF=2.511)

36、Gao H, Qian J, Cao S, Yang Z, Pang Z, Pan S, Fan L, Xi Z, Jiang X, Zhang Q. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials. 2012, 33(20):5115-5123.(IF=7.604)高被引论文

37、Gao H, Qian J, Yang Z, Pang Z, Xi Z, Cao S, Wang Y, Pan S, Zhang S, Wang W, Jiang X, Zhang Q. Whole-cell SELEX aptamer-functionalised poly(ethyleneglycol)-poly(epsilon-caprolactone) nanoparticles for enhanced targeted glioblastoma therapy. Biomaterials. 2012, 33(26): 6264-6272. (IF=7.604)

38、Gao H, Yang Z, Cao S, Xi Z, Zhang S, Pang Z, Jiang X. Behavior and anti-glioma effect of lapatinib-incorporated lipoprotein-like nanoparticles. Nanotechnology.2012,23(43):435101. (IF=3.842)

39、Gao H, Pang Z, Pan S, Cao S, Yang Z, Chen C, Jiang X. Anti glioma effect and safety of docetaxel-loaded nanoemulsion. Arch Pharm Res. 2012,35(2):333-341. (IF=1.538)

40、Gao H, Pan S, Yang Z, Cao S, Chen C, Jiang X, Pang Z, Hu Y. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials. 2011, 32(33): 8669-8675. (IF=7.404)

41、Gao H, Pang Z, Lu W, Pan S, Jiang X. Encapsulation of cationic peptides into polymersomes through in situ gelatinization. J Microencapsul. 2011, 28(6): 465-471. (IF=1.553)

42、Gao H, Pang Z, Fan L, Hu K, Wu B, Jiang X. Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations. Acta Pharmacol Sin. 2010,31(2): 237-243. (IF=1.953)




综述和书的章节

1、Gao H, Jiang X. Brain delivery using nanotechnology. In Di Liand Edward H. Kerns. Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects, John Wiley & Sons, Inc. 2015, chapter 24, 521-534.

2、Gao H, Zhang Q, Yu Z, He Q. Cell-penetrating peptide-based intelligent liposomal systems for enhanced drug delivery. Curr Pharm Biotechnol. 2014, 15(3):210-219.

3、Gao H, He Q. The interaction of nanoparticles with plasma proteins and the consequent influence on nanoparticles behavior. Expert Opin Drug Deliv. 2014,11(3): 409-420. (IF=4.84)

4、Gao H, Jiang X. Progress on the diagnosis and evaluation of brain tumors. Cancer Imaging.2013, 13(4): 466-481. (IF=1.592)

5、Gao H, Pang Z, Jiang X. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res. 2013, 30: 2485-2498.(IF=3.952)


编辑：四川大学华西药学院