吴剑波研究员，硕士/博士/博士后导师。西南医科大学药物研究与功能性食品研究中心主任，四川省"天然药物活性与分子药理"高校重点实验室主任。2015年创立泸州君益生物医学研究有限公司。担任中国微循环协会常务理事，第六届微循环专业委员会副主任委员。主要从事血管生成、血栓形成、葡萄糖稳态与胰岛素抵抗机制的研究。近年来主持承担了多项国家自然基金面上项目等支持。在Cancer Research、ATVB等国际生命科学高水平杂志发表SCI研究论文近40篇。

研究课题：
1. 国家自然科学基金委员会，面上项目，**，PAI-1及其糖基化玻连蛋白在糖尿病血管重构的作用和机制，2016-01至2019-12，62.4万元，结题，主持
3. 国家自然科学基金委员会，面上项目，**，PAI-1在肿瘤新生血管形成中对血管稳定性的作用及机制，2012-01至2015-12，60万元，结题，主持

近3年发表的研究论文
1. Fan X, Li K, Zhu L, Deng X, Feng Z, Xu C, Liu S, Wu J. Prolonged Therapeutic Effects of Photoactivated Adipose-derived Stem Cells following Ischemic Injury. Acta Physiol (Oxf). 2020 Apr 19. doi: 10.1111/apha.13475. Epub ahead of print. PMID: **. ( *, as corresponding author, 通讯作者).
2. Liu S, Li Y, Fan X, Li K, Xu C, Zhang L, Luo M, Wang L, Li R, Wu J. Transplantation of adipose tissue lacking PAI-1 improves glucose tolerance and attenuates cardiac metabolic abnormalities in high-fat diet-induced obesity. Adipocyte. 2020;9(1):170-178.
3. Liu Y, Wang L, Ren M, Chen N, He J, Xiong W, Li R, Li Y, Luo P, Wu J^*. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) stimulates platelet-dependent arterial thrombosis. J Cardio Vasc Med 2020; 6: 1-11.
4. Luo M, Xu C, Luo Y, Wang G, Wu J, Wan Q. Circulating miR-103 family as potential biomarkers for type 2 diabetes through targeting CAV-1 and SFRP4. Acta Diabetol. 2019 Oct 3. doi: 10.1007/s00592-019-01430-6. [Epub ahead of print]
5. Luo M, Wang G, Xu C, Zeng M, Lin F, Wu J, Wan Q. Circulating miR-30c as a predictive biomarker of type 2 diabetes mellitus with coronary heart disease by regulating PAI-1/VN interactions. Life Sci. 2019 Dec 15;239:117092.
6. Li R, Li K, Zhang L, Wang L, Chen N, Deng X, Luo M, Wu J^*. Autologous transplantation of photoactivated subcutaneous adipose tissue improves glucose homeostasis in high‐fat diet‐induced obese mice. Journal of Tissue Engineering and Regenerative Medicine 2019;13(9):1609-1617
7. Liu Y, Wang L, Luo M, Chen N, Deng X, He J, Zhang L, Luo P, Wu J^*. Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice. Am J Physiol Endocrinol Metab. 2019;316(2):E260-E267.
8. Zeng M, Luo Y, Xu C, Li R, Chen N, Deng X, Fang D, Wang L, Wu J, Luo M. Platelet-Endothelial Cell Interactions Modulate Smooth Muscle Cell Phenotype in an vitro Model of Type 2 Diabetes Mellitus. Am J Physiol Cell Physiol. 2019;316(2):C186-C197.
9. Wang L, Chen L, Liu Z, Liu Y, Luo M, Chen N, Deng X, Luo Y, He J, Zhang L, Hill MA, Li R, Wu J^*. PAI-1 Exacerbates White Adipose Tissue Dysfunction and Metabolic Dysregulation in High Fat Diet-Induced Obesity. Front Pharmacol. 2018;9:1087.
10. Chen L, Wang L, Li Y, Wuang L, Liu Y, Pang N, Luo Y, He J, Zhang L, Chen N, Li R, Wu J^*. Transplantation of Normal Adipose Tissue Improves Blood Flow and Reduces Inflammation in High Fat Fed Mice With Hindlimb Ischemia. Front Physiol. 2018;9:197.
11. Luo M, Ji Y, Luo Y, Li R, Fay WP, Wu J^*. Plasminogen Activator Inhibitor-1 Regulates the Vascular Expression of Vitronectin. J Thromb Haemost. 2017;15(12):2451-2460.
12. Pang N, Chen T, Deng X, Chen N, Li R, Ren M, Li Y, Luo M, Hao H, Wu J^*, Wang L. Polydatin Prevents Methylglyoxal-Induced Apoptosis through Reducing Oxidative Stress and Improving Mitochondrial Function in Human Umbilical Vein Endothelial Cells. Oxid Med Cell Longev. 2017:**.
13. Deng X, Liu Y, Luo M, Wu J, Ma R, Wan Q, Wu J^*. Circulating miRNA-24 and its target YKL-40 as potential biomarkers in patients with coronary heart disease and type 2 diabetes mellitus. Oncotarget. 2017;8(38):63038-63046.
14. Ren M, Li R, Chen N, Pang N, Li Y, Deng X, Wang L, Luo M, Liu Y, Hao H, Liu Y, Sun H, Wu J^*. Platelet-Derived Factor V Is a Critical Mediator of Arterial Thrombosis. J Am Heart Assoc. 2017;6(7). pii: e006345.
15. Luo M, Tan X, Mu L, Luo Y, Li R, Deng X, Chen N, Ren M, Li Y, Wang L, Wu J^*, Wan Q. MiRNA-21 mediates the antiangiogenic activity of metformin through targeting PTEN and SMAD7 expression and PI3K/AKT pathway. Sci Rep. 2017;7:43427.
16. Yang Y, Xiao L, Chen N, Li Y, Deng X, Wang L, Sun H, Wu J^*. Platelet-derived factor V promotes angiogenesis in a mouse hind limb ischemia model. J Vasc Surg. 2017;65(4):1180-1188.e1.