博士生导师：陈元伟
陈元伟 博士
国家特聘专家
国家****引进人才
四川省百人计划引进人才
2012年度成都市十佳科技创新人才
基本信息
姓　　名： 陈元伟　　??????????????????? ??性??? 别： 男
出生日期： 1963年9月16日?????????????????? ?学??? 历： 博士 （Ph. D）
国籍： 美国??????????E-mail?? ：yuanwei.chen@yahoo.com

教育经历：
1979.09～1983.07? 四川大学? 学士? 专业：有机合成
1983.09～1986.07? 四川大学? 硕士? 专业：有机合成
1989.10～1993.07? 瑞士洛桑大学(University of Lausanne)? 博士学位? 专业：有机合成
?导师：著名化学家Pirre Vogel教授
1993.07～1995.06? 美国The? Scripps? Research? Institute? 博士后，从事催化抗体的研究
?导师：研究院院长/美国院士Richard Lerner教授
工作经历：
1995.05～1998.12?? 美国爱博特制药公司（Abbott Laboratories，芝加哥）资深研究员。
1998.12～2002.01?? 美国拜尔制药公司（Bayer Corporation） 高级研究科学家
2002.02～2005.02?? 美国拜尔制药公司（Bayer Corporation） 首席研究科学家，肥胖病新药研究项目主
?公司药物研究中心化学系安全委员会主席
2005.02～2008.03?? 白鹭医药技术（上海）有限公司?? 首席科学官
2008.03～2012???? 上海睿智化学研究有限公司????? 药物化学研发副总裁
????? 成都睿智化学研究有限公司???? 总经理
2011.10-今天?四川大学/中国科学院成都有机化学研究所，博士生导师， 2011年****特聘专家
获奖
1.?2011年度成都十佳科技创新人才
2.?2011年国家****
3.?2009年四川省百人计划
4.?2004年中国科学院百人计划
5.?2002年美国拜耳制药公司特殊贡献奖
6.?2001年美国拜耳制药公司特殊贡献奖
7.?2000年美国拜耳制药公司特殊贡献奖
8.?1993年瑞士洛桑大学最佳博士论文奖
社会兼职
1.?四川省特聘专家
2.?成都市战略咨询决策平台专家
3.?四川省华侨华人协会副主席
4.?成都市生物医药服务外包产业联盟理事长
5.?四川省第九批学术和技术带头人
6.?美国化学会会员
7.?美中医药协会会员
个人评价及主要业绩：
陈元伟博士是旅美教授专家协会副会长、美国化学学会、北美洲中国学人国际交流中心及美国中医药协会会员。在瑞士洛桑大学就读期间，其负责的项目“多醣化合物的合成”获得瑞士洛桑大学优秀博士论文奖；在美国爱博特制药公司就职期间，成功研制出具有独立知识产权的抗流行性感冒新药，获得“美国爱博特制药公司特殊贡献奖”；在美国拜尔制药公司就任期间，由于出色完成“新型抗癌药物合成”、“糖尿病药物合成”、“抗癌药物合成”等研发项目，连续3年获得了拜尔制药公司 “特殊贡献奖”。陈元伟博士是国际国内生物医药界著名的归国留学人员、企业家、药物化学家、博士生导师；曾任中国科学院博士生导师，百人计划引进人才，国家手性药物中心副主任；上海白鹭医药技术有限公司创始管理人，首席科技官；上海睿智化学总公司副总经理；凯惠医药发展有限公司总经理；曾多次被邀请在国际国内学术会议上发表药物还行， 归国创业演讲；获得国际专利30项，发表国际论文32篇。
1)?在美国博士后研究期间，首次发现对Aldol反应有催化活性的抗体。独创烯烃环氧化甲醛/过氧化氢氧化体系。该工作被美国著名杂志C&N作为专题报道
2)?在美国Abbott Lab.（雅培公司）工作期间，成功研制出具有独立知识产权的抗流行性感冒新药。
3)?在美国Bayer（拜尔）制药公司，领导研究小组研制出新型治癌药物并获专利10余项。领导 20人的研究小组攻克肥胖病新药开发课题，工作范围包括：药物分子的设计，药物合成，动物药理，动物模型设计，专利申请等。
4)?美国化学学会会员、北美洲中国学人国际交流中心会员、旅美教授专家协会会员， 美中医药协会会员。
5)?2005年被美国哈佛大学、麻省理工大学教授， 国际著名发明家， 企业家，Brian Seeds聘用回上海开创新药研发公司并担任核心创始管理人－公司首席科技官。从零开始，在短短三年时间将公司做成全国少数具有自主产权的公司，并研发出具有独立自主产权的治疗Ⅱ型糖尿病新药，该药已完成临床前研究及临床实验用药GMP生产、动物毒理实验，目前正在准备申报美国FDA。白鹭医药也成为上海张江在自主创新领域的明星企业。
6)?在中科院百人计划期间，培养博士毕业生5人，硕士生1人，并在国际刊物发表论文13篇。
7)?担任国家手性中心副主任期间积极推动公司海外业务，为公司获得总经费资助1140万元，并获得国家2500万元工程中心平台建设资助。
8)?2008年3月， 受聘于凯惠医药发展（成都）有限公司总经理，上海睿智化学研究有限公司副总经理，在短短半年时间， 已经将公司人员增加了50％。 建立了具有8位归国博士的管理团队。 并和世界上最著名药物公司建立了业务关系。 并积极推动成都高新区生物医药产业的发展。
个人专长：
陈元伟博士主要研究药物分子的设计，药物合成，动物药理，动物模型设计，专利申请等，具有丰富的化学合成药物研发经验和企业管理经验。在美国从事博士后研究工作期间，首次发现Aldol反应有催化活性的抗体，独创烯烃环氧化甲醛/过氧化氢氧化体系。该工作被美国著名杂志C&N作为专题报道。在上海白鹭医药公司工作期间，研发出具有独立自主产权的治疗Ⅱ型糖尿病新药，该药已完成临床前研究及临床实验用药GMP生产、动物毒理实验，目前正在准备申报美国FDA。
（1）代表性论著（论文）
发表时间?论著（论文）名称?发表载体?论著（论文）作者
2010年?ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors?Bioorganic & Medicinal Chemistry?Xu, Baihua; Feng, Yan; Lv, etx Seed, Brian; Chen, Yuanwei**
2010年?Conformationally Constrained Spiro C-Arylglucosides as Potent and Selective Renal Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors?ChemMedChem?Lv, Binhua; Feng, etc,Welihinda, Ajith; Seed, Brian; Chen, Yuanwei**
2009年?Exploration of O-spiroketal C-aryl-glucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors?Bioorganic & Medicinal Chemistry Letters?Lv, Binhua; Xu, Baihua;? etc, Seed, Brian; Chen, Yuanwei.**
2008年?Reduction of ? 2-Isoxazolines to ? -Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent.?Journal of Organic Chemistry ?Jiang, Dahong; Chen, Yuanwei..
2008年?Synthesis of 3-alkyl-1H-quinolin-2-ones via palladium-catalyzed intramolecular cyclization of benzyl halides and ,-unsaturated amides.?
Synlett?
Liu, Zhangqin Chen, Yuanwei.? etal.
2008年?Pd-Catalyzed Carboetherification of ? ,? -Unsaturated Oximes: A Novel Approach to ? 2-Isoxazolines?
Organic Letters?Jiang, Dahong; Chen, Yuanwei. etal.
2008年?Palladium-catalyzed cascade one-pot synthesis of 5-arylmethylisoxazolidines from N-homoallylhydroxylamines with aryl bromides??
Tetrahedron? ?
Jiang, Dahong; Chen, Yuanwei. etal.
2008年?Palladium-catalyzed cascade one-pot synthesis of 5-arylmethylisoxazolidines from N-homoallylhydroxylamines with aryl bromides?
Tetrahedron? ?Jiang, Dahong; Chen, Yuanwei. etal.
（2）专利
专利保护期?专利名称?授权国家?专利所有者
2009年2月?Preparation of benzylbenzene glycoside derivatives as antidiabetic agents.?美国? ?Song,Yanli;Chen,Yuanwei etal.
2008年10月?Preparation of benzylic glycoside derivatives and their inhibitory effect on sodium-dependent glucose co-transporter SGLT.? ?
美国? ?
Chen, Yuanwei.? etal.
2008年7月?Preparation of spiro-heterocyclic glycosides for treating diseases and conditions which are affected by SGLT inhibition.?
美国? ?Hadd, Michael J.; Chen, Yuanwei. etal.
2007年5月?Preparation of spiro glycosides as glucose transport inhibitors.?美国? ?
Chen, Yuanwei.? etal.
2006年4月?Preparation of pyrimidine derivatives and their use for the treatment of cancer.?
美国? .?Nagarathnam, Dhanapalan; Chen, Yuanwei; etal.
2006年10月?Preparation of diaminopyrimidines as anticancer drugs.?
美国? ?Nagarathnam, Dhanapalan; Chen, Yuanwei; etal.
2005年12月?Preparation of amino-substituted pyrimidines as antitumor agents.? ?美国? ?Dixon, Chen, Yuanwei. etal.
2004年7月?Preparation of bicyclic (hetero)aryl- and pyridine-containing diaryl ureas as Raf kinase and angiogenesis inhibitors useful in the treatment of cancer and other disorders.?
美国? ?
Dumas; Chen, Yuanwei. etal.

发表专利:
1.?Song, Yanli; Chen, Yuanwei; Cheng, Huawei; Li, Shengbin; Wu, Yuelin; Feng, Yan; Lv, Binhua; Xu, Baihua; Seed, Brian; Hadd, Michael J.; Du, Jiyan; Wang, Congna; Roberge, Jacques Y.?? Preparation of benzylbenzene glycoside derivatives as antidiabetic agents.??? PCT Int. Appl.? (2009),???? 156pp.? CODEN: PIXXD2? WO? **? A1? **
2.?Chen, Yuanwei; Feng, Yan; Xu, Baihua; Lv, Binhua; Seed, Brian; Hadd, Michael J.; Cheng, Huawei; Sheng, Zelin; Xu, Min; Wang, Congna; Du, Jiyan; Zhang, Lili; Xu, Ge; Wu, Yuelin.?? Preparation of benzylic glycoside derivatives and their inhibitory effect on sodium-dependent glucose co-transporter SGLT.??? U.S. Pat. Appl. Publ.? (2008),???? 59pp.? CODEN: USXXCO? US? **? A1? **?
3.?Hadd, Michael J.; Chen, Yuanwei; Feng, Yan; Sen, Sengen; Seed, Brian.?? Preparation of spiro-heterocyclic glycosides for treating diseases and conditions which are affected by SGLT inhibition.??? U.S. Pat. Appl. Publ.? (2008),???? 53pp.? CODEN: USXXCO? US? **? A1? **
4.?Hadd, Michael J.; Chen, Yuanwei; Feng, Yan; Sen, Sengen; Seed, Brian.?? Preparation of spiro-heterocyclic glycosides for treating diseases and conditions which are affected by SGLT inhibition.??? PCT Int. Appl.? (2008),???? 109 pp., which.? CODEN: PIXXD2? WO? **? A2? **
5.? ?Chen, Yuanwei; Feng, Yan; Xu, Baihua; Lv, Binhua; Dong, Jiajia; Seed, Brian; Hadd, Michael J.? (USA).? Preparation of spiro glycosides as glucose transport inhibitors. U.S. Pat. Appl. Publ.? (2007). 63pp. US? **? A1? **???? Application: US? 2007-752226? **.
6.? ?Nagarathnam, Dhanapalan; Chen, Yuanwei; Fu, Wenlang; Wang, Ming; Bierer, Donald; Brands, Michael; Wang, Yamin; Bear, Brian R.; Miller, David; Schmitt, Aaron; Mull, Eric; Zhao, Jin.? Preparation of pyrimidine derivatives and their use for the treatment of cancer.? PCT Int. Appl.? (2006), 56pp. WO? **? A1? **. Application: WO 2006-US13505? **.?
4. ?Nagarathnam, Dhanapalan; Chen, Yuanwei; Fu, Wenlang; Wang, Ming; Bierer, Donald; Brands, Michael; Wang, Yamin; Bear, Brian R.?? Preparation of diaminopyrimidines as anticancer drugs.??? PCT Int. Appl.? (2006),???? 42pp. WO? **? A2? **?
8. ?Dixon, Julie A.; Nagarathnam, Dhanapalan; Zhang, Lei; Wang, Chunguang; Yi, Lin; Chen, Yuanwei; Chen, Jianqing; Bear, Brian R.; Brands, Michael; Hillisch, Alexander; Bierer, Donald; Wang, Ming; Fu, Wenlang; Hentemann, Martin F.; Bullion, Ann-Marie; Patel, Manoj.?? Preparation of pyrimidine derivatives for treatment of hyperproliferative disorders.??? PCT Int. Appl.? (2006),???? 100pp. WO? **? A1? **?
9. ?Dixon, Julie A.; Nagarathnam, Dhanapalan; Zhang, Lei; Wang, Chunguang; Yi, Lin; Chen, Yuanwei; Chen, Jianqing; Bear, Brian R.; Brands, Michael; Hillisch, Alexander; Bierer, Donald; Wang, Ming; Fu, Wenlang; Hentemann, Martin F.; Bullion, Ann-Marie; Patel, Manoj.?? Preparation of amino-substituted pyrimidines as antitumor agents.??? U.S. Pat. Appl. Publ.? (2005),???? 182 pp., Cont.-in-part of Appl. No. PCT/US04/033430. US? **? A1? **
10.?Dixon, Julie A.; Nagarathnam, Dhanapalan; Zhang, Lei; Wang, Chunguang; Yi, Lin; Chen, Yuanwei; Chen, Jianqing; Bear, Brian; Brands, Michael; Hillisch, Alexander; Bierer, Donald; Wang, Ming; Fu, Wenlang; Hentemann, Martin F.; Bullion, Ann-Marie.? Preparation of pyrimidine derivatives as antitumor agents. PCT Int. Appl.? (2005), 276 pp.? WO? **? A2? **
11.?Dumas, Jacques; Boyer, Stephen; Verma, Sharad; Adnane, Lila; Chen, Yuanwei; Lee, Wendy; Phillips, Barton; Smith, Roger A.; Scott, William J.; Burke, Jennifer; Chen, Jianqing; Chen, Zhi; Fan, Jianmei; Miranda, Karl; Raudenbush, Brian; Redman, Aniko; Shao, Jianxing; Su, Ning; Wang, Gan; Yi, Lin; Zhu, Qingming.? Preparation of bicyclic (hetero)aryl- and pyridine-containing diaryl ureas as Raf kinase and angiogenesis inhibitors useful in the treatment of cancer and other disorders.??? PCT Int. Appl.? (2004),???? 162 pp. WO? **? A2? **
12.?Scott, William J.; Dumas, Jacques; Boyer, Stephen; Lee, Wendy; Chen, Yuanwei; Phillips, Barton; Verma, Sharad; Chen, Jianqing; Chen, Zhi; Fan, Jianmei; Raudenbush, Brian; Redman, Aniko; Yi, Lin; Zhu, Qingming.? Preparation of ureidophenoxycyanopyridines as anticancer drugs.??? PCT Int. Appl.? (2004),???? 127 pp. WO? **? A1? **
13.?Dumas, Jacques; Lee, Wendy; Chen, Yuanwei; Adnane, Lila; Scott, William J.; Verma, Sharad; Chen, Jianging; Chen, Zhi; Yi, Lin.? Preparation of pyridine-containing diaryl ureas useful in the treatment of cancer and other disorders.??? PCT Int. Appl.? (2004),???? 96 pp. WO? **? A2? **
14.?Chen, Yuanwei; O'Connor, Stephen James; Gunn, David; Newcom, Jason; Chen, Jianqing; Yi, Lin; Zhang, Hai-jun; Hunyadi, Laszlo Matyas; Natero, Reina.? Preparation of substituted 3,5-dihydro-4H-imidazol-4-ones for the treatment of obesity.??? PCT Int. Appl.? (2004),???? 344 pp. WO? **? A1? **
15.?Wood, Jill E.; Bierer, Donald; Bear, Brian; Brennan, Catherine; Chandler, Brent; Chen, Gang; Chen, Yuanwei; Dixon, Julie; Fu, Wenlang; Guernon, Leatte; Liu, Donglei; McClure, Andrea; Miranda, Karl; Nagarathnam, Dhanapalan; Sibley, Robert; Turner, Michael; Verma, Sharad; Wang, Chunguang; Yi, Lin; Zhao, Jin; Zhu, Qingming.? Preparation of 2,4-bis(phenylamino)pyrimidine derivatives for treating hyperproliferative disorders.??? PCT Int. Appl.? (2004),???? 159 pp. WO? **? A2? **
16.?Wood, Jill E.; Chen, Yuanwei; Hart, Barry; Yi, Lin; Chen, Jianqing.? Pyrimidine derivatives for treatment of hyper-proliferative disorders.??? PCT Int. Appl.? (2004),???? 27 pp. WO? **? A2? **
17.?Wood, Jill E.; Chen, Yuanwei; Chen, Jianqing; Hart, Barry; Liu, Donglei; Verma, Sharad K.? Preparation of pyridinylaminopyrimidines useful for treating hyper-proliferative disorders.??? PCT Int. Appl.? (2003),???? 36 pp. WO? **? A1? **? CAN 139:381504? AN 2003:913161??? CAPLUS
18.?Dumas, Jacques; Sibley, Robert; Smith, Roger; Su, Ning; Chen, Yuanwei; Wood, Jill; Guernon, Leatte; Dixon, Julie; Brennan, Catherine; Boyer, Stephen.? Preparation of quinazolines and quinolines as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents.??? PCT Int. Appl.? (2003),???? 266 pp. WO? **? A1? **? AN 2003:532653
19.?Stolle, Andreas; Bierer, Donald E.; Chen, Yuanwei; Can, Dongping Fan; Hart, Barry; Monahan, Mary Katherine; Scott, William J.? Preparation and pharmaceutical compositions of 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines for use in the treatment or prevention of PDE7B-mediated diseases and conditions.??? U.S. Pat. Appl. Publ.? (2003),???? 62 pp., Cont.-in-part of U.S. Provisional Ser. No. 287,629. US? **? A1? **
20.?Dumas, Jacques; Kluender, Harold C. E.; Zhang, Chengzhi; Chen, Yuanwei; Hong, Zhenqiu; Hatoum-Mokdad, Holia; Lee, Wendy.? Preparation of N-(oxazolylphenyl)-2,4-diaminopyrimidines for treatment of hyperproliferative disorders.??? PCT Int. Appl.? (2003),???? 65 pp. WO? **? A1? **
21.?Stolle, Andreas; Bierer, Donald E.; Chen, Yuanwei; Fan, Dongping; Hart, Barry; Monahan, Mary Ketherine; Scott, William J.? Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines as phosphodiesterase PDE7B inhibitors.??? PCT Int. Appl.? (2002),???? 148 pp. WO? **? A1? **
22.?Nagarathnam, Dhanapalan; Wang, Chunguang; Chen, Yuanwei; etc? 2- and 4-Aminopyrimidines N-substituted by a bicyclic ring for use as kinase inhibitors in the treatment of cancer. (Bayer Corporation, USA).??? PCT Int. Appl.? (2003),???? 118 pp. WO? **? A1? Application: WO? 2002-US30616? **.?
23.?Maring, Clarence J.; Chen, Yuanwei, etc Preparation of cyclopentanecarboxylates and related compounds as inhibitors of neuraminidases.??? U.S.? (2003),???? 153 pp., Cont.-in-part of U.S. Ser. No. 282,138, abandoned. USXXAM? US? **? B1? **.
24.?Maring, Clarence J.; Gu, Yu Gui; Chen, Hui-Ju; Chen, Yuanwei; etc? Preparation of pyrrolidine neuraminidase inhibitors.??? U.S.? (2002),???? 253 pp, US? **? B1
25.?Stolle, Andreas; Bierer, Donald E.; Chen, Yuanwei; Fan, Dongping; Hart, Barry; Monahan, Mary Ketherine; Scott, William J.? Novel 4-amino-5,6-substituted thiopheno[2,3-d]pyrimidines as phosphodiesterase PDE7B inhibitors.??? PCT Int. Appl.? (2002),???? 148 pp. WO? **.
26.?Clarence Maring, Yu-Gui GU, Yuanwei Chen, etc “Preparation of pyrrolidines as inhibitors of neuraminidases EP **, April 4, 2001.
27.?Maring, Clarence J.; Giranda, Vincent L.; Kempf, Dale J.; Stoll, Vincent S.; Sun, Minghua; Zhao, Chen; Gu, Yu Gui; Hanessian, Stephen; Wang, Gary T.; Krueger, Allan C.; Chen, Hui-ju; Chen, Yuanwei; Degoey, David A.; etc “Preparation of pyrrolidine neuraminidase inhibitors”, WO **, April 26,2001
28.?Maring, Clarence J.; Giranda, Vincent L.; Kempf, Dale J.; Stoll, Vincent S.; Sun, Minghua; Zhao, Chen; Gu, Yu Gui; Wang, Gary T.; Krueger, Allan C.; Chen, Yuanwei; Degoey, David A.; Grampovnik, David J.; Kati, Warren M.; etc “Preparation of cyclopentanecarboxylates and analogs as neuraminidase? Inhibitors”, WO **, April 26, 2001
29.?Clarence Maring, Yu-Gui GU, Chen, Yuanwei, etc “Preparation of pyrrolidines as inhibitors of neuraminidases WO **, October 28, 1999.
30.?Maring, Clarence J.; Gu, Yu-Gui; Chen, Yuanwei; Degoey, David A.; Giranda, Vincent L.; Grampovnik, David J.; etc.; “Preparation of aminocyclopentanecarboxylates and analogs as influenza virus neuraminidase inhibitors”. WO **, October 28, 1999.
31.?J. L. Reymond, Yuanwei Chen, " Aldol condensations employing catalytic antibody with primary amine cofactor", U. S. Patent, 5,576,174, November? 19, 1996.
32.?Reymond, Jean Louis; Chen, Yuanwei; Lerner, Richard A. "Antibody Catalysis of Cyclohexadieneone Rearrangements", U, S, Patent, 5,500,358,? March 19, 1996?
33.?Chen, Yuanwei, Mi Aiqiao, Xiao Xun, Jiang Yaozhong; "Asymmetric Synthesis of Optically Purely Active? Substituted Benzylamine"; Faming Zhuanli Shenqing Gongkai Shuomingshu; Chinese Patent, CN 1,039,582; CN 1,014,885, 14 Feb, 1990, CA: 114:P6009d.
34.?Aiqiao Mi,? Xun Xiao,? Yuanwei Chen; "Preparation of Flucythrinate"; Chinese Patent; Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1,034,708, Aug. 16 1989, CA: 113:P152053j.
发表文章:
1.??Xu, Baihua; Feng, Yan; Lv, Binhua; Xu, Ge; Zhang, Lili; Du, Jiyan; Peng, Kun; Xu, Min; Dong, Jiajia; Zhang, Wenbin; Zhang, Ting; Zhu, Liangcheng; Ding, Haifeng; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei.?? ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.??? Bioorganic & Medicinal Chemistry? (2010),? 18(12),? 4422-4432.?
2.??Lv, Binhua; Feng, Yan; Dong, Jiajia; Xu, Min; Xu, Baihua; Zhang, Wenbin; Sheng, Zelin; Welihinda, Ajith; Seed, Brian; Chen, Yuanwei.?? Conformationally Constrained Spiro C-Arylglucosides as Potent and Selective Renal Sodium-Dependent Glucose Co-transporter 2 (SGLT2) Inhibitors.??? ChemMedChem? (2010),? 5(6),? 827-831?
3.??Xu, Baihua; Lv, Binhua; Feng, Yan; Xu, Ge; Du, Jiyan; Welihinda, Ajith; Sheng, Zelin; Seed, Brian; Chen, Yuanwei.?? O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.??? Bioorganic & Medicinal Chemistry Letters? (2009),? 19(19),? 5632-5635.
4.??Jiang, Dahong; Chen, Yuanwei.?? Reduction of ? 2-Isoxazolines to ? -Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent.??? Journal of Organic Chemistry? (2008),? 73(22),? 9181-9183
5.??Liu, Zhangqin; Shi, Changqing; Chen, Yuanwei.?? Synthesis of 3-alkyl-1H-quinolin-2-ones via palladium-catalyzed intramolecular cyclization of benzyl halides and ? ,? -unsaturated amides.??? Synlett? (2008),?? (11),? 1734-1736
6.??Jiang, Dahong; Peng, Jinsong; Chen, Yuanwei.?? Pd-Catalyzed Carboetherification of ? ,? -Unsaturated Oximes: A Novel Approach to ? 2-Isoxazolines.??? Organic Letters? (2008),? 10(9),? 1695-1698
7.??Jiang, Dahong; Peng, Jinsong; Chen, Yuanwei.?? Palladium-catalyzed cascade one-pot synthesis of 5-arylmethylisoxazolidines from N-homoallylhydroxylamines with aryl bromides.??? Tetrahedron? (2008),? 64(8),? 1641-1647.?
8.??Jiang, Dahong; Peng, Jinsong; Chen, Yuanwei, Palladium-catalyzed cascade one-pot synthesis of 5-arylmethylisoxazolidines from N-homoallylhydroxylamines with aryl bromides. Tetrahedron? (2008),? 64(8),? 1641-1647.
9.??Peng, Jinsong; Lin, Wenqing; Jiang, Dahong; Yuan, Shixue; Chen, Yuanwei,?? Preparation of a 7-Arylthieno[3,2-d]pyrimidin-4-Amine Library. Journal of Combinatorial Chemistry? (2007),? 9(3),? 431-436.
10.??Peng, Jinsong; Jiang, Dahong; Lin, Wenqing; Chen, Yuanwei, Palladium-catalyzed sequential one-pot reaction of aryl bromides with O-homoallyl-hydroxylamines: synthesis of N-aryl-? -amino alcohols. Organic & Biomolecular Chemistry? (2007),? 5(9),? 1391-1396.
11.??Peng, Jinsong; Lin, Wenqing; Yuan, Shixue; Chen, Yuanwei, Palladium-Catalyzed Highly Stereoselective Synthesis of N-Aryl-3-arylmethylisoxazolidines via Tandem Arylation of O-Homoallylhydroxylamines. Journal of Organic Chemistry? (2007),? 72(8),? 3145-3148.
12.??Stoll, Vincent; Stewart, Kent D.; Maring, Clarence J.; Muchmore, Steven; Giranda, Vincent; Gu, Yu-gui Y.; Wang, Gary; Chen, Yuanwei; Sun, Minghua; Zhao, Chen; Kennedy, April L.; Madigan, Darold L.; Xu, Yibo; Saldivar, Ayda; Kati, Warren; Laver, Graeme; Sowin, Thomas; Sham, Hing L.; Greer, Jonathan; Kempf, Dale.? Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series.??? Biochemistry? (2003),? 42(3),? 718-727.
13.??J. L. Reymond,? Yuanwei Chen, “Enantioselective Epoxidation of a Library with Catalytic Antibodies”, Synthesis,? 2001, 6, 934-936
14.??Gary T. Wang,* Sheldon Wang, Yuanwei Chen, Robert Gentles, and Thomas Sowin ; Synthesis of 2-Substituted (±)-(2R,3R,5R)-Tetrahydrofuran-3,5-dicarboxylic Acid Derivatives, J. Org. Chem; 2001; 66(6); 2052-2056
15.??Gary T. Wang, Yuanwei Chen, Sheldon Wang, Robert Gentles, Thomas Sowin, Warren Kati, Steve Muchmore, Vincent Giranda, Kent Stewart, Hing Sham, Dale Kempf, and W. Graeme Laver# ; Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores, J. Med. Chem.? 2001; 44(8); 1192-1201.
16.??Gary T Wang, Yuanwei Chen, Sheldon Wang, Richard Sciotti and Thomas Sowin, "Solid Phase Synthesis of Ureas of Secondary Amines via Carbamoyl Chloride", Tetrahedron Lett. 38, 1895, 1997
17.??Jean-Louis Reymond, Yuanwei Chen, “Antibody-catalyzed uni- and multi-substrate reactions compared using transition-state binding (KTS)” Isr. J. Chem. (1996), 36(2), 199-206
18.??J. L. Reymond, Yuanwei Chen, "Catalytic, Enantioselective Aldol Reaction with Artificial Aldolase Assembled from a Primary Amine and an Antibody", J. Org. Chem. 1995, 60, 6970-6979.
19.??Yuanwei Chen, J. L. Reymond, "Epoxidation of Olefins with Formamide-Hydrogen Peroxide", Tetrahedron Lett. 1995, 36, 4015-4018.
20.??J. L. Reymond,? Yuanwei Chen, "Catalytic, Enantioselective Aldol Reaction Using Antibodies Against A Quaternary Ammonium Ion with a Primary Amine Cofactor", Tetrahedron Lett. 1995, 36, 2575-2578.
21.??Yuanwei Chen, J. L. Reymond, Richard. A. Lerner, "An Antibody-Catalyzed 1,2-Rearrangement of Carbon-Carbon Bond", Angew. Chem., 1994, (15), 1607.
22.??Sylviane Picasso, Yuanwei Chen, P. Vogel; "Glycosidase Inhibition by 1,5-Dideoxy-1,5-iminooctitols and 1,2,6,7,8-Pentahydroxyindolizidines", Carbohydrate Lett., 1994, 1(1), 1.
23.??Yuanwei Chen, Pierre Vogel; "Total Asymmetric Synthesis of 1,5-Dideoxy-1,5-iminooctitols and 1,2,6,7,8-Pentahydroxyindolizidines"; J. Org. Chem.,1994, 59, 2487.
24.??Yuanwei Chen, Pierre Vogel; "Total Synthesis of 1.5-Dideoxy-1,5-Imino-D-erythro-L-allo-Octitol and (1S,2R,6R,7R,8S,8aS)-Pentahydroxyindolizidine"; Tetrahedron Letter, 1992, 33, 4917, CA:234308t.
25.??Aiqiao Mi, Yuanwei Chen, Xiao Hun, Liu Shikui, Wu Lanjun, Jiang Yaozhong; "Stereoselective Synthesis via Chiral Pinanone "; Youji Huahue, 1993, 13(2), 199,? CA:119:72857h.
26.??Denis-Pierre Neff, Yuanwei Chen, Pierre Vogel; "New Total Synthesis of D-threo--L-talo-Octose"; Helv. Chim. Acta., 1991, 74(3), 508-16. CA: 115:92768a.
27.??Aiqiao Mi, Yuanwei Chen, Wang Jiang, Jiang Yaozhong; "Asymmetric Carbonyl Addition with Homochiral Ketimine Derived from (+)- or (-)-Pinanone and Benzylamine"; Chin. J. Chem., 1990, (6), 561-7, CA:115:28783z.
28.??Yuanwei Chen, Mi Aiqiao, Xiao Xun, Jiang Yaozhong; "Asymmetric Synthesis of Chiral? Substituted Benzylamine via Pinanone Ketimine Template"; Huaxue Xuebao, 1990, 48(11), 1131-5, CA: 114:163619v.
29.??Xun Xiao, Mi Aiqiao, Yuanwei Chen, Jiang Yaozhong; "Stereocontrolled Synthesis of a New Chiral Ketimine Template"; Youji Huaxue, 1991, 11(1), 26-8, CA: 114:207516r.
30.??Yuanwei Chen, Mi Aiqiao, Jiang Yaozhong; "Stereocontrolled Synthesis of (R)- or (S)- a-Phenylethanamine"; Huaxue Tongbao, 1989, (12), 22, CA: 113:190816t.
31.??Aiqiao Mi,? Wang Jing, Yuanwei Chen, Jiang Yaozhong; "Asymmetric Synthesis IX: Stereocontrolled Synthesis of (R)- or? (S)-2-Amino-2-Phenylethanol via Chiral Pinanone Ketimine Template"; Synth. Commun., 1989, 19(9),3337-42,? CA: 113:23208q.
32.??Yuanwei Chen, Mi Aiqiao, Xiao Xun, Jiang Yaozhong; "Asymmetric Synthesis VIII. Enantioselective Synthesis of (R)- or (S)- a-Substituted Benzylamines via Chiral Pinanone Ketimine Template"; Synth. Commun. 1989, 19(7-8), 1423-30, CA:112:158647g.

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