廖建职 务:职 称:研究员学 历:博士研究生电 话:传 真:通讯地址:四川省成都市人民南路四段9号
邮政编码:610041电子邮件:jliao@cib.ac.cn
个人简历　　博士，研究员，博士生导师。1994年毕业于上海交通大学应用化学系， 2002年在中科院成都有机所获理学博士学位。2006年2月后被聘为中科院成都有机所研究员，任不对称合成与手性技术四川省重点实验室副主任，所学位评定委员会委员。2008年入选中国科学院“西部之光”人才计划，2009年入选四川省学术和技术带头人后备人选。2010年9月调入中科院成都生物所。现任天然产物研究中心主任、所学术委员会委员、中国科学院大学专业学位培养指导委员会委员、中科院四川转化医学研究医院学术委员会、四川省第二届药品安全专家委员会委员。主要从事手性配体设计、不对称催化以及天然产物合成研究。在国际核心学术刊物（包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Org. Lett.等）上发表学术论著40余篇，获准和申请了发明专利近10项。

研究方向　　手性配体设计与不对称催化反应方法学、天然产物合成方法学、药物及关键中间体合成

社会任职及荣誉（含获奖）
承担科研项目情况　　国家自然科学基金委面上项目
　　参加国家973计划子项目
　　中科院“西部之光”人才计划
　　中科院STS项目

代表论著　　1. X. Wang, B. Wang, X. Yin, W. Yu, Y. Liao, J. Ye, M. Wang, L. Hu, J. Liao* “Palladium Catalyzed Enantioselective Thiocarbonylation of Styrenes” Angew. Chem. Int. Ed. 2019, 58, in press, doi: 10.1002/anie. (hot paper)
　　2. B. Wang, X. Wang, X. Yin, W. Yu, Y. Liao, J. Ye, M. Wang, J. Liao* “Cu-Catalyzed SN2' Substitution of Propargylic Phosphates with Vinylarene-derived Chiral Nucleophiles: Synthesis of Chiral Allenes” Org. Lett. 2019, 21, 3913.
　　3. T. Jia, M. Wang, J. Liao* “Chiral Sulfoxide Ligands in Asymmetric Catalysis” Top Curr Chem 2019, 377, doi: 10.1007/s41061-019-0232-9.
　　4. B. Chen, P. Cao, Y. Liao, M. Wang, J. Liao* “Enantioselective Copper-Catalyzed Methylboration of Alkenes” Org. Lett. 2018, 20, 1346.
　　5. T. Jia, P. Cao*, J. Liao* “Enantioselective synthesis of gem-diarylalkanes by transition metal-catalyzed asymmetric arylations (TMCAAr)” Chem. Sci. 2018, 9, 546.
　　6. B. Chen, P. Cao, X. Yin, Y. Liao, L. Jiang, J. Ye, M. Wang, and J. Liao* “Modular Synthesis of Enantioenriched 1,1,2-Triarylethanes by an Enantioselective Arylboration and Cross-Coupling Sequence” ACS Catal., 2017, 7, 2425.
　　7. Y. Zhang, M. Wang, P. Cao, J. Liao* “Copper-catalyzed enantioselective aminoboration of styrenes with chiral sulfoxide phosphine ligand” Acta Chimica Sinica 2017, 75, 794.
　　8. L. Jiang, P. Cao*, M. Wang, B. Chen, B. Wang, J. Liao* “Highly Diastereo- and Enantioselective Cu-Catalyzed Borylative Coupling of 1,3-Dienes and Aldimines” Angew. Chem. Int. Ed., 2016, 55, 13854.
　　9. T. Yang, Y. Zhang, P. Cao, M. Wang, L. Li, D. Li*, J. Liao*, “Copper-catalyzed enantioselective conjugate addition of diethylzinc to acyclic enones with chiral sulfoxide–phosphine ligands” Tetrahedron, 2016, 72, 2707.
　　10. T. Jia, P. Cao, B. Wang, Y. Lou, X. Yin, M. Wang, J. Liao* “A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes” J. Am. Chem. Soc. 2015, 137, 13760 ( Highlighted by JACS Spots).
　　11. Y. Lou, P. Cao, T. Jia, Y. Zhang, M. Wang, J. Liao* “Cu-Catalyzed Enantioselective 1,6-Boration of para-Quinone Methides and Efficient Transformation of gem-Diarylmethine Boronates to Triarylmethanes” Angew. Chem. Int. Ed. 2015, 54, 12134.
　　12. T. Jia, P. Cao, D. Wang, Y. Lou, J. Liao* “Copper-Catalyzed Asymmetric Three-Component Borylstannation: Enantioselective Formation of C-Sn Bond” Chem. Eur. J. 2015, 21, 4918.
　　13. Liyin Jiang, Tao Jia, Min Wang, Jian Liao, and Peng Cao* “Pd-Catalyzed Enantioselective Hydroalkoxylation of Alkoxyallenes with Phenol for Construction of Acyclic O,O-Acetals” Org. Lett., 2015, 17 ,1070.
　　14. D. Wang, P. Cao, B. Wang, T. Jia, Y. Lou, M. Wang, J. Liao* “Copper(I)-Catalyzed Asymmetric Pinacolboryl Addition of N-Boc-imines Using a Chiral Sulfoxide–Phosphine Ligand” Org. Lett., 2015, 17, 2420.
　　15. J. Wang, B. wang, P. Cao, J. Liao* “Rhodium Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to β,γ-Unsaturated α-Keto Ester Using Chiral tert-Butanesulfinylphosphines Ligands” Tetrahedron Lett. 2014, 55, 3450.
　　16. J. Wang, M. Wang, P. Cao, L. Jiang, G. Chen, J. Liao* “Rh-Catalyzed Asymmetric Arylation of β,γ-Unsaturated α-Ketoamides for the Construction of Nonracemic γ,γ-Diarylcarbonyls” Angew. Chem. Int. Ed. 2014, 53, 6673. (Highlighted by Synfacts, 2014, 1042)
　　17. L. Du, P. Cao, J. Liao* “Bifunctional Ligand Promoted Pd-Catalyzed Asymmetric Allylic Etherification/Amination” Acta Chimica Sinica 2013, 71, 1239.
　　18. L. Du, P. Cao, J. Xing, Y. Lou, L. Jiang, L. Li, J. Liao* “Hydrogen Bond Promoted Palladium Catalysis: Allylic Alkylation of Indoles with Unsymmetrical 1,3-Disubstituted Allyl Acetates Using Chiral Bis(sulfoxide) Phosphine Ligands” Angew. Chem. Int. Ed. 2013, 52, 4207.
　　19. J. Gui, G. Chen, P. Cao, J. Liao* “Rh(I)-catalyzed asymmetric addition of arylboronic acids to NH isatins” Tetrahedron: Asymmetry 2012, 23,554.
　　20. J. Xing, P. Cao, J. Liao* “Chiral SO/P hybrid ligands: an enantioselective switch in palladium-catalyzed asymmetric allylic etherifications” Tetrahedron: Asymmetry 2012, 23, 527.
　　21. G. Chen, J. Gui, P. Cao, J. Liao* “Chiral sulfoxideeolefin ligands: tunable stereoselectivity in Rh-catalyzed asymmetric 1,4-additions” Tetrahedron 2012, 68, 3220.
　　22. G. Chen, J. Xing, P. Cao, J. Liao* “Rh/chiral sulfinylphosphine catalyzed asymmetric 1,4-addition of arylboronic acids to chalcones” Tetrahedron 2012, 68, 5908.
　　23. J. Xing, G. Chen, P. Cao, J. Liao* “Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acids to Indolylnitroalkenes” Eur. J. Org. Chem. 2012, 1230.
　　24. X. Zhang, G. Chen, P. Cao, J. Liu, J. Liao* “Rhodium-Catalyzed Michael Addition of Arylboronic Acids to 3-Alkylenyloxindoles: Asymmetric Synthesis of Functionalized Oxindoles” Tetrahedron Lett. 2012, 53, 438.
　　25. G. Chen, J. Gui, L. Li, J. Liao* “Chiral Sulfoxide-Olefin Ligands: Completely Switchable Stereoselectivity in the Rh-Catalyzed Asymmetric Conjugate Additions” Angew. Chem. Int. Ed. 2011, 50, 7681 (hot paper, Highlighted by Synfacts, 2011, 1193).
　　26. F. Han, G. Chen, X. Zhang, J. Liao* “Chiral Hetero-Disulfoxide Ligands in Rhodium-Catalyzed Asymmetric 1,4-Addition of Arylboronic Acids to Chromenones” Eur. J. Org. Chem. 2011, 2928.
　　27. F. Lang, G. Chen, L. Li, J. Xing, F. Han, L. Cun, J. Liao* “Rhodium-Catalyzed Highly Enantioselective Addition of Arylboronic Acids to 2-Nitrostyrenes by tert-Butanesulfinylphosphine Ligand” Chem. Eur. J. 2011, 5242 (Highlighted by Synfacts, 2011, 882).
　　28. J. Liu, G. Chen, J. Xing, J. Liao* “tert-Butanesulfinylthioether ligands: synthesis and application in palladium-catalyzed asymmetric allylic alkylation” Tetrahedron: Asymmetry 2011, 22, 575.
　　29. X. Zhang, J. Chen, F. Han, L. Cun, J. Liao* “Rhodium-Catalyzed Enantioselective Conjugate Addition of Sodium Tetraaryl-borates to 2,3-Dihydro-4-Pyridones and 4-Quinolones by Using (R,R)-1,2-bis(tert-butylsulfinyl)benzene as Ligand” Eur. J. Org. Chem. 2011, 1443.
　　30. F. Han, J. Chen, X. Zhang, J. Liu, L. Cun, J. Zhu, J. Deng, J. Liao* “Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α, β-unsaturated carboxylic acid esters: an approach to γ-amino acids” Tetrahedron Lett. 2011, 52, 830.
　　31. J. Chen, J. Chen, F. Lang, X. Zhang, L. Cun, J. Zhu, J. Deng, J, Liao* “A C₂-Symmetric Chiral Bis-Sulfoxide Ligand in Rhodium-Catalyzed Reaction: Asymmetric 1, 4- Addition of Sodium Tetraarylborates to Chromenones” J. Am. Chem. Soc. 2010, 132，4552. (Highlighted by Synfacts, 2010, 790.)
　　32. F. Lang, D. Li, J. Chen, J. Chen, L. Li, L. Cun, J. Zhu, J. Deng, J. Liao* “tert-Butanesulfinylphosphines: Simple Chiral Ligands in Rhodium-Catalyzed Asymmetric Addition of Arylboronic Acid to Electron-Deficient olefins” Adv. Synth & Catal. 2010, 352, 843. ( Highlighted by Synfacts, 2010, 667)
　　33. P. Wang, J. Chen, L. Cun, J. Deng, J. Zhu, J. Liao* “Aryl tert-Butyl Sulfoxide-Promoted Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Org. Biomol. Chem., 2009, 7, 3741.
　　34. X. Guan, Zh. Liu, H. Huang, L. Yang, J. Liao*, W. Hu* “Novel C–S Bond Formation Through a’,b-Elimination of tert-Butyl Sulfoxonium Ylides: A Facile Approach to Chiral Sulfoxides” Synlett. 2009, 2183.
　　35. J. Chen, F. Lang, D. Li, L. Cun, J. Zhu, J. Deng, J. Liao* “Palladium-catalyzed asymmetric allylic nucleophilic substitution reactions using chiral tert-butanesulfinylphosphine ligands” Tetrahedron: Asymmetry 2009, 20, 1953.(Highlighted by Synfact, 2009, 1374).
　　36. 廖建，邓金根 《不对称催化新概念与新方法》，（丁奎岭、范青华主编）第20章：不对称催化—从学术研究到工业应用（典型案例分析）。2009年，化学工业出版社。
　　37. D. Li, J. Deng, J. Zhu, J. Liao* “Synthesis of 3,3'-Substituted Biphenyl and Binaphthyl-based Phosphoramidite Ligands” Chin. Synth. Chem. 2008, 16, 656.
　　38. J. Chen, D. Li, H. Ma, L. Cun, J. Zhu, J. Deng, J. Liao* “Catalytic asymmetric synthesis of α-branched chiral amines using a novel chiral tert-butanesulfinylphosphine ligand”Tetrahedron Lett. 2008. 49. 6921.
　　39. J. Liao; Qing Wang* “Ruthenium-Catalyzed Knoevenagel Condensation: A New Route toward Cyano-Substituted Poly(p-phenylenevinylene)s” Macromolecules 2004, 37, 7061.
　　40. J. Liao; X. X. Sun; X. Cui; K. B. Yu; J. Zhu; J. G. Deng* “Facile optical resolution of tert-butanethiosulfinate by molecular complexation with (R)-BINOL and study of chiral discrimination of the diastereomeric complexes” Chem. Eur. J. 2003, 9, 2611.
　　41. J. Liao; X. H. Peng; J. H. Zhang; K. B. Yu; X. Cui; J. Zhu; J. G. Deng* “Facile resolution of racemic terbutaline and a study of molecular recognition through chiral supramolecules based on enantiodifferentiating self-assembly” Org. & Biomol. Chem. 2003, 1, 1080.