个人简历　　唐亚雄，男，汉族，博士，研究员，研究生导师。1993年毕业于四川大学生物工程系微生物学专业，1993-1997年在江苏省镇江制药有限责任公司工作，1997-2002年在四川大学生命科学学院攻读硕士、博士学位，期间在中国科学院微生物研究所植物基因组学国家重点实验室完成博士论文，遗传学理学博士。2003-2005年先后在美国纪念斯隆－凯特琳癌症中心(Memorial Sloan-Kettering Cancer Center)、美国迈阿密大学(University of Miami)从事博士后研究工作，2005-2008年在美国加州大学欧文分校(University of California Irvine)从事助理研究员工作。2009年进入中国科学院成都生物研究所并组建以肿瘤前沿研究为主的信号转导与分子靶向药物实验室，主要从事基于Wnt信号通路的抗肿瘤蛋白质药物以及抗癌小分子化合物的活性筛选与分子药理学研究。已在Cancer Research、Molecular Cancer Therapeutics、Cancer Prevention Research、International Journal of Cancer、Molecular Cancer、Neoplasia等学术期刊上共发表论文20余篇，相关论文已被Nature Structural & Molecular Biology、Cancer Research等国际学术期刊他引200余次。现为美国肿瘤研究协会（AACR）高级会员、四川省细胞生物学会理事、四川省遗传学会理事，Molecular Medicine、Molecular Cancer等学术期刊审稿人，国家自然科学基金、四川省及成都市科技计划项目评审专家。?

研究方向肿瘤分子细胞生物学

分子靶向药物

代表论著近年SCI论文（*表示通讯作者）：

　　1. Tang Y, Simoneau AR, Xie J, Shahandeh B, Zi X. Effects of the Kava Chalcone Flavokawain A Differ in Bladder Cancer Cells with Wild-type versus Mutant p53. Cancer Prevention Research 2008, 1(6):439-51. ?

　　(Perspectives: Rajesh Agarwal and Gagan Deep. Kava, a Tonic for Relieving the Irrational Development of Natural Preventive Agents. Cancer Prevention Research 2008, 1(6):409-412.)?

　　2. Guo Y, Xie J, Rubin E, Tang Y, Lin F, Zi X, Hoang BH. Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling. Cancer Research 2008, 68(9):3350-60.?

　　3. Tang Y, Simoneau AR, Liao W, Guo Y, Hoang BH, Hope C, Liu F, Li S, Xie J, Holcombe RF, Jurnak FA, Mercola D, Zi X. WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells. Molecular Cancer Therapeutics 2009, 8(2): 458-68.?

　　4. Tang Y, Li X, Liu Z, Simoneau AR, Xie J, Zi X. Flavokawain B, a kava chalcone, exhibits robust apoptotic mechanisms on androgen receptor-negative, hormone-refractory prostate cancer cell lines and reduces tumor growth in a preclinical model. International Journal of Cancer 2010, 127(8):1758-68. ?

　　5. Yee DS, Tang Y, Li X, Liu Z, Guo Y, Ghaffar S, McQueen P, Atreya D, Xie J, Simoneau AR, Hoang BH, Zi X. The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition. Molecular Cancer 2010, 9(1):162. ?

　　6. Tang Y, Parmakhtiar B, Simoneau AR, Xie J, Fruehauf J, Lilly M, Zi X. Lycopene enhances docetaxel’s effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels. Neoplasia 2011, 13(2):108-119. ?

　　7. Zhao X, Chao Y, Wan Q, Chen X, Su P, Sun J, Tang Y*. Flavokawain B induces apoptosis of human oral adenoid cystic cancer ACC-2 cells via up-regulation of Bim and down-regulation of Bcl-2 gene expression. Canadian Journal of Physiology and Pharmacology 2011, 89(12): 875-882.?

　　8. Zhao X, Chao Y, Chen P, Liu D, Su P, Cui X, Sun J, Tang Y*. hRpn13, a newly identified component of 19S particle, regulates the proliferation, differentiation and function in human osteoblast-like cell line MG63. Journal of Physiology and Biochemistry 2012, 68(1):153,129-139. ?

　　9. An J, Gao Y, Wang J, Zhu Q, Ma Y, Wu J, Sun J, Tang Y*. Flavokawain B induces apoptosis of non-small cell lung cancer H460 cells via Bax-initiated mitochondrial and JNK pathway. Biotechnology Letters 2012, 34(10):1781-1788. ?

　　10. Zhang X, Li F, Zhao Z, Liu X, Tang Y, Wang M. Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities. Phytochemistry Letters 2012,5(4):721-724.?

　　11. Wang L, Wang J, Li F, Liu X, Chen B, Tang Y, Wang M. Cytotoxic Sesquiterpene Lactones from Aerial Parts of Xanthium sibiricum. Planta Medica 2013, 79(8):661-665.?

　　12. Ren L, Liu Y, Guo L, Wang H, Ma L, Zeng M, Shao X, Yang C, Tang Y, Wang L, Liu C, Li M. Loss of Smu1 function de-represses DNA replication and over-activates ATR-dependent replication checkpoint. Biochemical and Biophysical Research Communications 2013, 436(2):192-198.?

　　13. Li F, Pan H, Liu X, Chen, B, Tang Y, Xi X, Wang M. New phenanthrene glycosides from Dendrobium denneanum and their cytotoxic activity. Phytochemistry Letters 2013,6:640-644. ?

承担科研项目情况　　目前主持国家自然科学基金、四川省国际科技合作与交流计划等科研项目。?

获奖及荣誉