姓名：李天柱


职称：副教授 职务：教研室主任

所在系部及教研室：医学院分子生物学教研室


教学经历：
2014年-2017年 赤峰学院医学院 讲师
2017.12年-至今 赤峰学院医学院 副教授
2016年-至今 锦州医科大学同等学力申请硕士学位课程 赤峰培训基地教师
2017年-至今 锦州医科大学 硕士研究生导师

教研项目及成果：
1.医学细胞生物学教学改革与探讨,赤峰学院学报. 2016
2.基础医学理论及其当代发展,吉林大学出版社.2016

科研项目及成果：
科研项目：
1.内蒙古自然科学基金项目：ELK3在上皮细胞-间充质转化及肝癌细胞侵袭和转移中的作用机制,主持，2015-2017
2.国家自然科学基金项目：Toll样受体在IgG4相关性唾液腺炎发病中的作用及其机制研究，第二参与，2018-2021
3. 内蒙古高等学校创新平台培育项目：内蒙古人类遗传病研究重点实验室， 第四参与，2015-2017
科研论文：
1.Tian Zhu Li, Jung Eun Choi, Sung Min Kim, et al. Elk-3 contributes to the progression of liver fibrosis through regulating epithelial-mesenchymal transition. Gut Liver, 15;11(1):102-111，(SCI, IF: 2.6), 2017
2. Tian Zhu Li, Cheng Zhe Jin, Byung Hyune Choi, et al. Using cartilage extracellular matrix (CECM) membrane to enhance the reparability of the bone marrow stimulation technique for articular cartilage defect in canine model. Adv Funct Mater, 22:4292-300, (SCI, IF: 10.179), 2012
3.Tian Zhu Li, Jae Hyung Kim, Hyun Hee Cho, et al. Therapeutic potential of bone marrow-derived mesenchymal stem cells differentiated with growth factor-free co-culture method in liver-injured rats. Tissue Eng Part A, 16(8):2649-59, (SCI, IF:4.636), 2010
4.Tian Zhu Li, Sang-Hyun Shin, Hyun Hee Cho,et al. Growth factor-free cultured rat bone marrow derived mesenchymal stem cells towards hepatic progenitor cell differentiation. Biotechnol Bioprocess Eng, 13:659-65, (SCI, IF:1.004), (2008)
5. Sung Min Kim, Jung Eun Choi, Wonhee Hur, Jung Hee Kim, Sung Woo Hong, Eun Byul Lee, Joon Ho Lee, Tian Zhu Li, et al. RAR-Related Orphan Receptor Gamma (ROR-γ) Mediates Epithelial-Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis. J Cell Biochem，118(8):2026-2036，(SCI, IF: 3.085), 2017
6.Jae Hyung Kim, Sang-Hyun Shin, Tian Zhu Li, et al. Influence of in vitro bio-mimicked stem cell “Niche” for regulation on proliferation and differentiation of human bone-marrow derived mesenchymal stem cells into myocardial phenotypes: serum starvation without aid of chemical agent and prevention of spontaneous stem cell transformation enhanced by matrix environment. J Tissue Eng Regen Med, 10(1):E1-13，(SCI, IF: 3.534), 2016
7. Jung Eun Choi, Wonhee Hur, Jung-Hee Kim, Tian Zhu Li, et al. MicroRNA-27a Modulates HCV Infection in Differentiated Hepatocyte-like Cells from Adipose Tissue-derived Mesenchymal Stem Cells. Plos One, 13:9(5):e91958, (SCI, IF: 3.730), 2014
8.Sung Woo Kim, Wonhee Hur, Tian Zhu Li, et al. Oleuropein prevents the progression of steatohepatitis to hepatic fibrosis induced by a high-fat diet in mice. Experimental & Molecular Medicine, 46:e92, (SCI, IF: 2.573), 2014
9.Jae Won Choi, Byung Hyune Choi, Sang-Hyug Park, Ki Soo Pai, Tian Zhu Li, et al. Mechanical stimulation by ultrasound enhances BM-MSC chondrogenic differentiation in a fibrin-HA hydrogel. Artif Organs, 37(7):648-55, (SCI, IF: 2), 2013
10.Jae Hyung Kim, Kyoo-Ho Shin, Tian Zhu Li, Hwal Suh. Potential of nucleofected human MSCs for insulin secretion. J Tissue Eng Regen Med, 5(10):761-9, (SCI, IF: 3.534), 2011
11.Jung Mi Han, Byung Joon Chang, Tian Zhu Li, et al. Protective effects of ascorbic acid against lead-induced apoptotic neurodegeneration in the developing rat hippocampus in vivo. Brain Res, 1185:68-74, (SCI, IF:2.623), 2007
12. 李天柱，史铁伟，周静，等. 干扰ELK-3抑制肝癌细胞的上皮-间质转换. 基础医学与临床，37(2):211-216. (北大中文核心)，2017
13. 李天柱，王加茹，张俊毅，等. 肝癌组织ELK-3蛋白的表达及ELK-3对肝癌HepG2细胞迁移和侵袭能力的影响. 吉林大学学报（医学版），已录用，（北大中文核心），2018
发明专利：
1.专利名：Biomaker ELK3 for diagnosing liver fibrosis.
发明者： Seung Kew Yoon, Tian Zhu Li, Won Hee Hur, Sung Min Kim, Sung Woo Kim
申请国：韩国
专利号：10-2
公告日期：2013.7.29
2. 专利名：Biomaker RORC for diagnosing liver fibrosis.
发明者： Seung Kew Yoon, Tian Zhu Li, Won Hee Hur, Sung Min Kim, Sung Woo Kim
申请国：韩国
专利号：10-2
公告日期：2013.7.29