导师简介
导师姓名袁波性别男出生年月1962.01导师类别硕导
研究方向药物动力学及药物质量控制方法研究
联系电话**/**职称/院士教授
E-mailboyuan1962@163.com导师学位博士
学院（工作单位）药学院
信箱（地址）39号信箱


袁 波
所在院系 药学院药物分析系
通信地址 沈阳市文化路103号39# 沈阳药科大学分析化学教研室
邮 编 110016
科研课题
1. 临床前药物转运、代谢及动力学研究平台 负责人 沈阳市科技局
2. 可触发释药的聚合物胶束给药系统构建及靶向异质性肿瘤细胞的研究 2/8 国家自然科学基金委
3. 七十种中药注射液指纹图谱研究及其技术平台的建立 2/2 国家科技攻关计划项目子科题
4. 基于血清动态图谱和多组分药代动力学四逆散药效物质基础及配伍机理研究 3/8 国家自然科学基金委
5. 抗癌创新中药葫芦素B及其制剂新药临床前研究 3/12 科技部“十一五”重大科技专项
6. 静电干粉包衣技术在中药固体制剂中的应用 3/5 国家重点实验室开放基金
7．多功能胶束的构建及逆转肿瘤多药耐药的研究 3/8 辽宁省自然科学基金委
8. 拉米夫定片生物等效性研究等9项、盐酸胍法辛缓释制剂犬动力学研究等6项 负责人
9. 二甲双胍牛磺酸胶囊质量标准和犬体内药动学研究等5项（新药研究） 负责人
近年来在国内外主要刊物上发表学术论文近60篇，第一或通讯作者40篇，SCI收载12篇。代表性论文：
1.Haiyan Xu,Jingjing Gan,Xiaohong Liu,Ruiyang Wu,Yi Jin,Bo Yuan.Gender-dependent pharmacokinetics of lignans in rats after single and multiple oral administration of Schisandra chinensis extract. J Ethnopharmacol . 2013, 147(1,2):224-231
2. Yuan B, Li L, Jin Y, Fu Y, Y, Li C, Xu H. Development and validation of a LC-MS/MS method for quantification of the regioisomers of dihydroxybutylether in human plasma. J Chromatogr B. 2012, 911(1): 27-33
3. Yuan B, Wang L, Jin Y, Zhen H, Xu P, Xu Y, Li C, Xu H. Role of metabolism in the effects of genistein and its phase II conjugates on the growth of human breast cell lines. AAPS J. 2012; 14: 329-344.
4. Xu H, Lv S, Qiao M, Fu Y, Jiang X, Jin Y, Li C, Yuan B. Development and validation of a liquid chromatography-tandem mass spectrometry method for quantification of decitabine in rat plasma. J Chromatogr B. 2012; 899: 81-85.
5. Yuan B, Zhen H, Jin Y, Xu L, Jiang X, Sun S, Li C, Xu H. Absorption and plasma disposition of genistin differ from those of genistein in healthy women. J Agric Food Chem. 2012; 60: 1428-1436.
6. Yuan B, Zhai N, Jiang X, Jin Y, Liu C, Li C, Xu H. Quantitative determination of tiopronin in human plasma by LC-MS/MS without derivatization. Biomed Chromatogr. 2012; 26: 839-843.
7. Yuan B, Liu C, Xu P, Lin L, Pan C, Wang L, Xu H. Validated HPLC method for the quantitative determination of CoQ(10) in dog plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2011; 25: 1038-1044.
8. Bo Yuan, Xuan Wang, Feng Zhang, Jun Jia, Fangling Tang. Simultaneous Determination of Ramipril and Its Active Metabolite Ramiprilat in Human Plasma by LC-MS/MS. Chromatographia. 2008; 68: 533-539.
9. Yuan B, Qiao MX, Xu HY, Wang L, Li FM. Determination of Chlorogenic Acid in Rat Plasma by High Performance Chromatography after Peritoneal Administrtion of Compound Daqingye InjectionH. Yakugakuzasshi. 2006; 9: 811-814.
10. Li FM, Yuan B, Xiong ZL, Lu XM, Chen HS, Liu ZG. Fingerprint Analysis of Flos Lonicerae japonicae using binary HPLC profiling. Biomed Chromatogr. 2006; 20: 634-641.
11. Yang H, Yuan B, Li L, Chen H, Li FM. HPLC determination and pharmacokinetics of Chlorgenic Acid in Rabbit Plasma after an Oral Dose of Flos Lonicerae Extract. J chorm sci. 2004; 42: 173-176 .
12. Zhang DD, Yuan B, Qiao MX, Li FM. HPLC determination and pharmacokinetice of sustainedrelease bupropion. J Pharm Biomed Anal. 2003; 33: 287-293.