导师简介
导师姓名吴春福性别男出生年月1959.02导师类别硕导, 博导
研究方向（1）中枢神经递质代谢与药物的相互作用、（2）成瘾性药物作用机理及防治、（3）中药分子毒理学、（4）中药复方的证治药理学等
联系电话**职称/院士教授
E-mailchunfuw@gmail.com导师学位博士
学院（工作单位）生命科学与生物制药学院
信箱（地址）31号信箱

吴春福，男，1959年2月出生，山东人。1982年毕业于沈阳药学院，留校任教。1992年、1994年分别两次破格晋升为副教授、教授，1996年被评为博士生导师。1996年任沈阳药科大学常务副校长，2000年任校长，2010年任党委书记兼校长，2011年任校党委书记。2000年获日本北海道药科大学博士学位。分别于2002、2004、2006年赴美国哈佛大学、英国牛津大学、美国密歇根大学进修政府管理、教育管理等课程。

1985年由国家公派赴意大利进修神经药理学，在国际上率先建立了应用脑内透析技术测定清醒动物脑内神经递质乙酰胆碱释放的方法，并应用此技术研究了药物和衰老对乙酰胆碱释放的影响，先后在J. Neurochem.、 J. Pharmacol. Exp. Ther.、Neurobiol. Aging、Proc. Natl. Acad. Sci. USA等国际学术刊物上发表了论文， 研究工作的水平达到该领域国际前沿, 获得了"药理学研究专家"证书。目前吴春福教授为药理学学术带头人，主要从事中枢神经药理学、肿瘤药理学、中药药理学的研究。在药物对乙醇引起大鼠抗坏血酸释放影响的机制、西洋参中分离得到的单体拟人参皂苷F11的中枢神经系统作用与机制、合成化合物靶向抗肿瘤作用与机制、小柴胡汤抗抑郁作用的作用机制与物质基础研究中都有许多重要发现，在国内外该学术领域已经具有一定的影响。

近年来先后主持了科技部“十一五”、“十二五”重大新药创制综合平台项目、国家自然科学基金（重点项目1项，面上项目若干项）、教育部青年骨干教师基金等重大课题的研究，并主编出版了《现代老年药学》、《药学概论》等多部学术著作。曾获得国家级教学成果二等奖、辽宁省教学成果一等奖、辽宁省科技进步一等奖、吴阶平保罗杨森医学药学研究二等奖，入选新世纪百千万人才工程国家级人选，被评为辽宁省优秀专家、辽宁省首批领军人才。为本科生和研究生开设讲授《中药药理学》、《专业英语》、《药学概论》、《分子药理学》、《神经生物学进展》等课程。近年来已培养研究生120余人，其中已毕业博士47名、硕士73名，另博士后出站5人。吴春福教授指导下两名研究生分别获得了Servier中国青年药理工作者奖，、两名博士生论文获辽宁省优秀博士论文奖。至今在国内外期刊共发表学术论文近327篇，其中SCI收录148篇。

现为中国药理学会常务理事、中国药学会副理事长、辽宁省药学会理事长、沈阳市科学技术协会副主席、辽宁省人民政府学位委员会委员等。兼任《Asian Journal of Traditional Medicines》主编, 《Internationl Immunopharmacology》、《Pharmacology,Biochemistry and Behavior》和《Asian Journal of Pharmacodynamics and Pharmacokinetics》编委、《中草药》副主任编委、《沈阳药科大学学报》主编，国际杂志《International Immunopharmacology》、《Pharmacology, Biochemistry and Behavior》、《International Journal of Neuropsychopharmacology》、《Progress inNeuro-Psychopharmacology & Biological Psychiatry》、《Journal of Ethnopharmacology》、《Food Chemistry》等的审稿人。

代表性文章：

1.Li YT, Li HH, Liu X, Bao GB, Tao YZ, Wu ZY, Xia P, Wu CF, Li BM, Ma L. Regulation of amygdalar PKA by -arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning. P Natl Acad Sci USA 2009;106(51):21918-21923. IF=9.432

2.Xu NJ, Bao L, Fan HP, Bao GB, Pu L, Lu YJ, Wu CF, Zhang X, Pei G. Morphine withdrawal increases glutamate uptake and surface expression of glutamate transporter GLT1 at hippocampal synapses J Neurosci. 2003;23(11): 4775-84. IF=8.306

3.Yang JY, Xue X, Tian H, Wang XX, Dong YX, Wang F, Zhao YN, Cui W, Wu CF＊. Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages. Pharmacol Ther. 2014. IF=7.745

4.Wang LH, Kim SH, Lee JH, Choi YL, Kim YC, Park TS, Hong YC, Wu CF, Shin YK. Inactivation of SMAD4 Tumor Suppressor Gene During Gastric Carcinoma Progression. Clin Cancer Res. 2007;13(1):102-110. IF=6.25

5.Chen X, Choi IY, Chang TS, Noh YH, Shin CY, Wu CF, Ko KH, Kim WK. Pretreatment with interferon-γ protects microglia from oxidative stress via up-regulation of Mn-SOD. Free Radical Bio Med. 2009;46(8):1204-1210. IF= 6.081

6.Wang FY, Wang LH, Zhao YF, Li Y,Ping GF, Xiao S, Chen K, Zhu WF, Gong P, Yang JY, Wu CF. A Novel Small-Molecule Activator of Procaspase-3 Induces Apoptosis in Cancer Cells and Reduces Tumor Growth in Human Breast, Liver and Gallbladder Cancer Xenografts. Mol Oncol.2014 IF=5.935

7.Qi J, Han WY, Yang JY, Wang LH, Dong YX, Wang F, Song M, Wu CF. Oxytocin regulates changes of extracellular glutamate and GABA levels induced by methamphetamine in the mouse brain. Addict Biol. 2012;17(4):758-769. IF=5.914

8.Zhao MY, Soderhall I, Park JY, Ma YG, Osaki T, Ha NC, Wu CF, Soderhall K, Lee BL. A Novel 43-kDa Protein as a Negative Regulatory Component of Phenoloxidase-induced Melanin Synthesis. J Biol Chem. 2005;280(26):24744-24751. IF=5.854

9.Liu P, Wu CF, Song W, Yu LS, Yang XF, Xiang RW, Wang F, Yang JY. Uridine decreases morphine-inducedbehavioral sensitization by decreasing dorsal striatal dopamine release possibly via agonistic effects at GABAA receptors. Eur Neuropsychopharmacol.2014 IF=5.395

10.Wang XX，Wang CM, Wang JM, Zhao SQ, Zhang K, Wang JM, Zhang W, Wu CF, Yang JY. Pseudoginsenoside-F11 (PF11) exerts anti-neuroin?ammatory effects on LPS-activated microglial cells by inhibiting TLR4-mediated TAK1/ IKK/NF- B, MAPKs and Akt signaling pathways. Neuropharmacology 2014; 79:642-656 IF=4.819

11.Sun JY, Yang JY, Wang F, Wang JY, Song W, Su GY, Dong YX, Wu CF. Lesions of nucleus accumbens affect morphine-induced release of ascorbic acid and GABA but not of glutamate in rats. Addict Biol. 2011;16(4):540-550. IF= 4.833.

12.Wang LH, Li Y, Yang SN, Wang FY, Hou Y, Cui W, Chen K, Cao Q, Wang S, Zhang TY, Wang ZZ, Xiao W, Yang JY, Wu CF. Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppr essing NF-κB and MAPK/HO-1 signalling.Br J Cancer. 2014;110(2):341-52 IF=4.817

13.Zhang H, Yang JY, Zhou F, Wang LH, Zhang W, Sha S, Wu CF. Seed Oil of Brucea javanica Induces Apoptotic Death of AcuteMyeloid Leukemia Cells via Both the Death Receptors and theMitochondrial-Related Pathways. Evid-based Compl Alt. 2011;1-14. IF= 4.774

14.Chen X, Wang N, Liu Y, Liu Y, Zhang T, Zhu L, Wang Y, Wu C＊, Yang J＊. Yonkenafil: A novel phosphodiesterase type 5 inhibitor induces neuronal network potentiation by a cGMP-dependent Nogo-R axis in acute experimental stroke.Exp Neurol. 2014 261:266-277. (IF=4.617)

15.Zhang Y, Lai WP, Wu CF, Favus MJ, Leung PC, Wong MS. Ovariectomy worsens secondary hyperparathyroidism in mature rats during low-Ca diet. Am J Physiol-Endoc M. 2007;292(3): 723-31. IF=4.138

16.Hou Y, Zhang HL, Xie GB, Cao XY, Zhao YN, Liu Y, Mao ZH, Yang JY, Wu CF＊. Neuronal injury, but not microglia activation, is associated with ketamine-induced experimental schizophrenic model in mice. PROG NEURO-PSYCHOPH. 2013;45:107-16. IF=4.025

17.Qi J, Yang JY, Wang F, Zhao YN, Song M, Wu CF. Effects of oxytocin on methamphetamine-induced conditioned place preference and the possible role of glutamatergic neurotransmission in the medial prefrontal cortex of mice in reinstatement. Neuropharmacology. 2009;56(5):856-865. IF=3.909

18.Chen XM, Wang NN, Zhang TY, Wang F, Wu CF＊, Yang JY＊. Neuroprotection by Sildenafil: Neuronal Networks Potentiation in Acute Experimental Stroke. CNS Neurosci Ther. 2014;20(1):40-9. IF=3.784

19.Wang LH, Yang JY, Yang SN, Li Y, Ping GF, Hou Y, Cui W, Wang ZZ, Xiao W, Wu CF. Suppression of NF-κB signaling and P-glycoprotein Function by Gambogic Acid Synergistically Potentiates Adriamycin -induced Apoptosis in Lung Cancer. Curr Cancer Drug Tar. 2014;14(1):91-103 IF=3.582

20.Yan Y, Yang JY, Mou YH, Wang LH, Zhang H, Wu CF. Possible metabolic pathways of ethanol responsible for oxidative DNA damage in human peripheral lymphocytes. Alcohol Clin Exp Res. 2011;35(1):1-9. IF=3.343

21.Han WY, Wang FY, Qi J, Wang F, Zhang LJ, Zhao SQ, Song M, Wu CF, Yang JY. NMDA receptors in the medial prefrontal cortex and the dorsal hippocampus regulate methamphetamine-induced hyperactivity and extracellular amino acid release in mice. Behav Brain Res. 2012;232(1):44-52. IF=3.327

22.Zhao YN, Wang F, Fan YX, Ping GF, Yang JY＊, Wu CF＊. Activated microglia are implicated in cognitive de?cits, neuronal death, and successful recovery following intermittent ethanol exposure. Behav Brain Res. 2012;236:270-282. IF=3.327