导师姓名张舟性别女出生年月1971.5导师类别硕导, 博导
研究方向中枢神经系统中氨基酸跨膜转运的分子机制、与氨基酸转运蛋白功能紊乱造成的神经退行性疾病的发生靶点及其专一性抑制剂的筛选白血病干细胞、白血病发生的机制及相关治疗药物的筛选
联系电话职称/院士教授
E-mailzhouzhang@hotmail.com导师学位博士
学院（工作单位）生命科学与生物制药学院
信箱（地址）沈阳药科大学22号信箱
张舟，女，1971年5月生于辽宁省抚顺市。1993年毕业于沈阳药科大学获学士学位，2000年毕业于中国科学院沈阳应用生态研究所获得博士学位。2000-2002年在中国科学院上海生物化学与细胞生物学研究所分子生物学国家重点实验室做博士后研究，2002-2007年在美国迈阿密大学医学院做博士后和资深研究人员。2008到上海师范大学生命与环境科学学院工作，同年破格评为教授。2012年底以人才引进的方式进入沈阳药科大学生命科学生物制药学院工作至今。2009年12月-2010年2月，到美国Binghamton University，SUNY进行学术交流；分别于2010年7-2010年8月、2012年7月-2012年8月到美国Loyola University进行学术交流。2014年3月被评为博士导师。
现任《沈阳药科大学学报》常务编委、《生物物理学》编委、上海市细胞生物学学会理事、上海市生物物理学会理事、美国生物物理学会会员、国家自然科学基金同行通讯评审专家。作为项目主持人主持国家自然科学基金3项、教育部回国人员基金1项、上海市科委重点项目1项、上海市教委重点项目2项，作为研究骨干参与科技部973重点项目课题1项。在中英文刊物上发表论文共近30篇，其中SCI论文16篇，包括J Exp Med、Mol Oncol、Leukemia、PNAS、JBC、Biochemical J、Biophysics J等国际一流刊物，总影响因子超过80，被他引超过90次。申请发明专利2项。
主要研究方向集中在（1）中枢神经系统中氨基酸跨膜转运的分子机制、与氨基酸转运蛋白功能紊乱造成的神经退行性疾病的发生靶点及其专一性抑制剂的筛选；（2）白血病干细胞、白血病发生的机制及相关治疗药物的筛选。
代表性文章：
1. Volk A, Li J, Xin J, You D, Zhang J, Liu X, Xiao Y, Breslin P, Li Z, Wei W, Schmidt R, Li X, Zhang Z, Kuo P, Nand S, Zhang J, Chen J, Zhang J. Sensitizing TNF-expressing acute myeloid leukemia cells to NF-kB inhibitor treatment by blocking TNF-JNK-AP1 signaling. J Exp Med. 2014,.In press. (SCI 13.214)
2. Zhang J, Seet CS, Sun C, Li J, You D, Volk A, Breslin P, Li X, Wei W, Qian Z, Zeleznik-Le NJ, Zhang Z＊, Zhang J＊. p27kip1 maintains a subs et of leukemia stem cells in the quiescent state in murine MLL-leukemia. Mol Oncol. 2013 Dec; 7(6): 1069-82. （＊共同通讯作者）(SCI 6.70)
3. Grewer C, Zhang Z, Mwaura J, Albers T, Schwartz A, Gameiro A. Charge compensation mechanism of a Na+-coupled, secondary active glutamate transporter. J. Biol. Chem. 2012, 287(32):26921-31 (SCI 5.33)
4. Zhang J., Xiao Y., Guo Y., Brelin P., Zhang S., Wei W., Zhang Z＊., Zhang J＊. Differential requirements for C-Myc in Chronic hematopoietic hyperplasia and acute hematopoietic malignancies in Pten-null mice. Leukemia, 2011 Dec;25(12):1857-68. （共同通讯作者） (SCI 8.96)
5. Zhang Z., Zander CB, Grewr C. The C-terminal domain of the neutral amino acid transporter SNAT2 regulates transport activity through voltage-dependent processes. Biochem J., 2011, 434(2):287-96 (SCI 5.16)
6. Zhang Z., Albers T., Fiumera HL., Gameiro A., and Grewer C. A conserved Na+ binding site of the sodium-coupled neutral amino acid transporter (SNAT2). J. Biol. Chem. 2009, 284(37):25314-26 (SCI 5.33)
7. Grewer C., Gameiro A., Zhang Z., Tao Z., Braams S., and Rauen T. Glutamate forward and reverse uptake: From molecular mechanism to transporter-mediated release after ischemia. IUBMB Life. 2008, 60(9):609-19 (SCI 3.58)
8. Zhang Z., Gameiro A., and Grewer C., Highly-conserved asparagines 82 controls the interaction of Na+ with the sodium-coupled neutral amino acid transporter SNAT2. J. Biol. Chem. 2008, 283(18): 12284-92. (SCI 5.33)
9. Zhang Z., Tao Z., Gameiro A., Barcelona S., Braanms S., Rauen T., and Grewer C. Transport direction determines the kinetics of substrate transport by the glutamate transport EAAC1. Proc Natl Acad Sci U S A. 2007, 104(46):18025-30. (SCI 9.43)
10. Zhang Z., and Grewer C., The sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substrates. Biophysical Journal. 2007, 92(1): 2621-32 (SCI 4.39)
11. Zhang Z., Papageorgiou G., Corrie J. and Grewer C., Pre-steady-state currents in neutral amino acid transporters induced by photolysis of a new caged alanine derivative. 2007. Biochemistry. 2007, 46(12): 3872-80 (SCI 3.22)
12. Tao Z., Zhang Z. and Grewer C., Neutralization of the aspartic acid residue D367, but not D454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1. J. Biol. Chem. 2006, 281(15): 10263-72 (SCI 5.33)
13. Guo Z., Zhang Z., Jia X., Tang Y. and Feng Y., Mutational analysis of the absolutely conserved B8Gly: consequence on foldability and activity of insulin. Acta Biochimica et Biophysica Sinica 2005, 37(10): 673-679 (SCI 0.51)
14. Zhang Z., Tang Y., Yao S., Zhu S. and Feng Y., Protein engineering of insulin: Two novel fast-acting insulins [B16Ala]insulin and [B26Ala]insulin. Science in China (Series C) 2003, 46(5):474-480. (SCI 0.48)
15. Zhang Z., Chen H., Tang Y. and Feng Y., A simple, economical method of converting gene expression products of insulin into recombinant insulin and its application. Progress in Natural Science. 2003. 13(8): 596-600. (SCI 0.44)
16. Gou Z., Tang Y., Zhang Z. and Feng Y., Mutational analysis of the three conserved valine residues of insulin and a proposal “isotype residue”. IUBMB Life. 2001, 52(6): 309-14. (SCI 2.7)
