导师简介
导师姓名赵余庆性别男出生年月1957.01导师类别硕导, 博导
研究方向天然抗肿瘤、降血糖成分的发现与构效关系研究
联系电话**/**职称/院士教授
E-mailzyq4885@126.com导师学位硕士
学院（工作单位）中药学院
信箱（地址）51号信箱

赵余庆，天然药化教授，博士生导师。1957年1月生，辽宁东港人。辽宁中医学院学士学位（1982年），沈阳药科大学天然药化专业硕士学位（1989年）。1992年晋升为副教授，1995年破格晋升为教授。2005-2006年美国伯明翰阿拉巴马大学高级访问学者。现任沈阳药科大学中药学院院长，辽宁省天然产物现代分离与工业化制备工程技术中心主任。兼任《中草药》、《中药材》杂志副主编，《中国中药杂志》、《中国现代中药》杂志编委，辽宁省中药学会常务理事。国家科技进步奖评审专家，国家科技型中小企业项目评审专家。

2006年10月调入沈阳药科大学工作以来，从人参、西洋参、三七、绞股蓝、苦瓜、山核桃、葡萄籽等药食同源植物中的发现新化合物100余个，共发表学术会议论文150多篇，SCI文章30余篇。

主持国家省市级科研项目20余项，“十一五”国家科技重大专项重大新药创制课题、国家科技部新药基金、国家“十五”重大科技攻关示范项目、中葡国际合作项目、国家自然基金、省市级科技项目20余项，累计获得各类项目资金2千余万元。申请国家发明专利20余项，1项国际发明专利，授权4项。获辽宁省科技进步奖一等奖1项，二等奖2项，三等奖6项；省医药科技进步奖一等奖2项；省教育厅科技进步奖二等奖1项；沈阳市科技进步奖二等奖2项。主编出版著作20余部。分别组建了“辽宁省天然产物现代分离与工业化制备工程技术研究中心”；校企共建“天然活性物质工业色谱制备实验室”；“沈阳市食品和药食同源品重金属和外源性有害物质检测重点实验室”。组建国家首个食品药学专业教研团队，开设6门必修课，2门选修课，4门实验课。已培养指导硕博士研究生80余名。



近年主要SCI论文：

1.Zhao Y, Wang W, Rayburn E, Hill DL, Wang H, Zhang R. Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng. Med Chem. 2007; 3:51-60

2.Wang W, Zhao Y(并列第一), Rayburn E, Hill DL, Wang H, Zhang R. In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chem Pharm. 2007; 59(5):589-601

3.YING HAN , BAOSHAN SIN , XIAOMIN HU , HONG ZHANG , BINHUI JIANG , MARIA ISABEL SPRANGER , AND YUQING ZHAO. Transformation of Bioactive Compounds by Fusarium sacchari Fungus Isolated from the Soil-Cultivated Ginseng. J.Agric.Food Chem. 2007,55(23): 9373-9379

4.Xiangrong Zhang , Dan Zhang , Jinhua Xu , Jingkai Gu ,Yuqing Zhao. Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies. J.Chromatogr.B. 858 2007, 65-70

5.Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hua liang Jiang, Ruiwen Zhang, Hui Wang. Structure-Activity Relationship and Substrate-Dependent Phenomenain Effects of Ginsenosides on Activities of Drug-Metabolizing P450 Enzymes. PLoS ONE. 2008, July,3(7):2697

6.X. Zhang,J. Xu,D. Zhang , J. Gu, Y. Zhao. Pharmacokinetics of 20(S)-25-methoxyl-dammarane -3, 12, 20-triol and its active metabolite after oral and intravenous administration in rat. Xenobiotica. 2009; 39(6): 457-464

7.Jia L, Zhao Y. Current evaluation of the millennium phytomedicine-ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem. 2009, 16(19): 2475-2484.

8.Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicine- ginseng (II): Collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem. 2009,16(22): 2924-2942.

9.Xiuli Bi, Yuqing Zhao,Wenfeng Fang, Wancai Yang. Anticancer activity of Panax notoginseng extract 20(S)-25-OCH3-PPD: targeting β-catenin signaling.Clinical and Experimental Pharmacology and Physiology. 2009,36: 1074–1078

10.Lin Shi, Jia-Qing Cao, Wei Li, and Yu-Qing Zhao. Three New Triterpene Saponins from Gynostemma pentaphyllu Helvetica Chimica Acta. 93( 2010):1785-1794

11.Y. Han, B. Sun, B. Jiang, X.Hu, M.I. Spranger, Y. Zhangand Y. Zhao. Microbial transformation of ginsenosides Rb1,Rb3 and Rc by Fusarium sacchari. Journal of Applied Microbiology. 2010, 109:792-798

12.Xiangrong Zhang, Xiaoning Ma, Bingkun Si,Yuqing Zhao. Simultaneous determination of five active hydrolysis ingredients from Panax quinquefolium L. by HPLC-ELSD. Biomed. Chromatogr. 2011,25:646–651

13.J M Zhao, N Li, H Zhang, C F Wu, H R Piao, Y Q Zhao. Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities. Bioorg.Med.Chem.Letts. 2011, 21:1027-1031

14.Cao Jiaqing, Zhang Yu, Cui,Jiongmo Zhao Yuqing.Two new cucurbitane triterpenoids from Momordica charantia L. Chinese Chemical Letters, 2011,22(4):583-586

15.Lin Shi, Jia-Qing Cao, Sheng-Ming Shi, Yu-Qing Zhao. Triterpenoid saponins from Gynostemma pentaphyllum. Journal of Asian Natural Products Research. 2011,13(2):168-177

16.Wan Xiao, Xian Li, Ning Li, Makabili Bolati, Xinjun Wang,Xiaoguang Jia, Yuqing Zhao. Sesquiterpene lactones from Saussurea involucrata. Fitoterapia. 2011, 82: 983–987

17.Xue-Kun Liu; Bai-Jun Ye; Yan Wu; Zhen-Hua Lin; Yu-Qing Zhao＊; Hu-Ri Piao＊＊. Synthesis and Anti-tumor Evaluation of Panaxadiol DerivativesEuropean. European Journal of Medicinal Chemistry. 2011, 46:1997-2002

18.Yan-ling Wu, Ying Wan, Xue-Jun Jin, Bing-Qing Ou Yang, Ting Bai, Yu-Qing Zhao＊, Ji-Xing Nan.＊＊ 25-OCH3-PPD induces the apoptosis of activated t-HSC/CI-6 cells viac-FLIP-mediated NF-κB activation. Chemico-Biological Interactions. 2011, 194:106–112

19.Wei LI, Jiaqing CAO, Linhui ZHANG, Qiangmin Xie,Yun Tang, Huijuan SHEN, Yuqing ZHAO. Cyclic bisdesmosides from Actinostemma lobatum MAXIM (Cucurbitaceae) and their in vitro cytotoxicity. Fitoterapia. 2012, 83:147-152

20.Miao Hao,Wei Wang,Yuqing Zhao,Ruiwen Zhang,Hui Wang.Pharmacokinetics and tissue distribution of 25-hydroxyprotopanaxadiol, an anti-cancer compound isolated from Panax ginseng, in athymic mice bearing xenografts of human pancreatic tumors. Eur J Drug Metab Pharmacokinet. 2011, 35:109-113

21.Li Xia, Cao Jiaqing, Zhao Yuqing. Two new dammarane-type sapogenins Gynostemma pentaphyllum. Chinese Chemical Letters, 2011, 22:1461-1464

22.Wu W, Bi X L,Cao J Q, Zhang K Q ,Zhao Y Q. Isolation and Identification of Compounds Responsible for Antitumor Activity of Carya cathayensis Shells. Bioorg.Med.Chem.Lett. 2012,22,1895–1898

23.Ning Li, Chun-Fu Wu, Xin-Yue Xu, Zhen-Yang Liu, Xian Li, Yu-Qing Zhao. Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum. European Journal of Medicinal Chemistry. 2012, 50,173-178

24.Xiaojing Wang, Wei Sun, Jiaqing Cao, Haiyan Qu, Xiuli Bi, Yuqing Zhao.Structures of New Triterpenoids and Cytotoxicity Activities of the Isolated Major Compounds from the Fruit of Momordica charantia L. J.Agric.Food Chem. 2012, 60, 3927?3933

25.Yuna Cui, Dawei Yi, Xiufeng Bai, Baoshan Sun, Yuqing Zhao＊, Yixuan Zhang＊＊. Ginkgolide B produced endophytic fungus (Fusarium oxysporum) isolated from Ginkgo biloba. Fitoterapia. 2012, 83: 913–920

26.Peng Wang, Xiu-Li Bi, Yu-Mei Guo, Jia-Qing Cao, Shi-Jun Zhang, Hao-Nan Yuan, Hu-Ri Piao＊,Yu-Qing Zhao＊＊.Semi-synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol Derivatives. European Journal of Medicinal Chemistry. 2012,55,137-145.


代表著作：

1.《四季防病药茶》，降脂抗衰药粥》，《补肾壮阳药酒》，《滋补健脑药汤》，《美容泽发药膏》系列丛书，辽宁科技出版社，2001，主编

2.《绿化血液》，《神奇的血清》，沈阳出版社，2001，主编

3.《脂肪肝四季饮食》，《高脂血症四季饮食》，《高血压四季饮食》，《糖尿病四季饮食》，《癌症四季饮食》，《慢性肾炎四季饮食》，《慢性胃炎四季饮食》系列丛书，辽宁科技出版社，2001，主编

4.《亚健康与保健食品概论》，科技出版社，2009，副主编

5.《保健食品研制思路与方法》，人民卫生出版社，2010，主编

6.《中药及天然产物提取制备关键技术》，中国医药科技出版社，2012，主编
荣誉称号：

1992年 辽宁省政府“青年先进工作者”

1995年 辽宁省政府“青年先进工作者”

2010 年“沈阳市优秀共产党员”