导师简介
导师姓名林斌性别男出生年月1979.8导师类别硕导
研究方向药物设计电脑模拟
联系电话职称/院士副教授
E-mailrandybinlin@sina.com导师学位博士
学院（工作单位）制药工程学院
信箱（地址）沈阳药科大学40号信箱

林斌，1979年8月生于湖南安化。2002年毕业于沈阳药科大学制药工程学院，获制药工程学士学位；2005年获得沈阳药科大学药物化学硕士学位。2005-2011年师从 University of Houston的 B. Montgomery Pettitt 教授，攻读Baylor College of Medicine的 Structural and Computational Biology and Molecular Biophysics （SCBMB）专业，研究溶剂自由能的快速计算的方法，获博士学位。2011-2013年在University of Maryland的 Alexander MacKerell 的指导下从事博士后工作，研究 DNA adducts 在癌症发病中的作用机制和 CHARMM 可极化力场（Drude）在混合溶液中的凝聚态模拟。2014年至今任沈阳药科大学制药工程学院药物化学系副教授。 主要研究方向：电脑模拟 DNA adducts 在致癌过程中的作用，力场参数的开发、评价和改进，计算机辅助药物药物设计。

发表文章：

1.Bin Lin, Xibing He, Alexander D. MacKerell, Jr. A Comparative Kirkwood-Buff Study of Aqueous Methanol Solutions Modeled by the CHARMM Additive and Drude Polarizable Force Fields, Journal of Physical Chemistry B, 117(36), 10572–10580, 2013

2.Bin Lin, Pedro E.M. Lopes, Benoit Roux, Alexander D. MacKerell, Jr. Kirkwood-Buff Analysis of Aqueous Amide Solutions modeled by the CHARMM Additive and Drude Polarizable Force Fields, Journal of Chemical Physics, 2013, 139(8), 084509, 2013

3.Bin Lin, Vipin Jain, Alexander D. MacKerell, Jr. and Bongsup P. Cho, Nucleotide excision repair of cluster acetylaminofluorene adducts on the NarI sequence: sequence dependence and structural factors, 2013, Chemical Research In Toxicology, 26 (8), 1251–1262, 2013

4.Bin Lin, Anusha Sandineni, Alexander D. MacKerell, Jr. and Bongsup P. Cho, Structure and thermodynamic insights on acetylaminofluorene-modified DNA duplexes as models for frameshift mutagenesis, Chemical Research In Toxicology, 26 (6), 937–951, 2013

5.Vipin Jain, B Hilton, Bin Lin, S Patnaik, F Liang, E Darian, Y Zou, Alexander D MacKerell, Bongsup Cho, Unusual sequence effects on nucleotide excision repair of arylamine lesions: DNA bending/distortion as a primary recognition factor, Nucleic Acids Research, 41(2), 869-880, 2013

6.Bin Lin, Ka-Yiu Wong, Char Hu, Hironori Kokubo, and B. Montgomery Pettitt, Fast Calculations of Electrostatic Solvation Free Energy from Reconstructed Solvent Density using proximal Radial Distribution Functions, Journal of Physical Chemistry Letters, 2(13), 1626-1632, 2011

7.Lin, B. and Pettitt, B. M., On the Universality of proximal Radial Distribution Functions of Proteins. Journal of Chemical Physics, 134(10), 106101, 2011

8.Lin, B. and Pettitt, B. M., Electrostatic solvation free energy of amino acid side chain analogs: Implications for the validity of electrostatic linear response in water. Journal of Computational Chemistry, 32(5), 878-885, 2011

9.Qinpeng Shen, Zhou Nie, Manli Guo, Chuan-Jian Zhong, Bin Lin, Wang Li, Shouzhuo Yao，Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator， Chemical Communication, (8), 929–931, 2009

10.Ren, J. H., Xiong, X. Q., Sha, Y., Yan, M. C., Lin, B., Wang, J., Jing, Y. K., Zhao, D. M., and Cheng, M. S., Structure prediction and R115866 binding study of human CYP26A1: homology modelling, fold recognition, molecular docking and MD simulations. Molecular Simulation, 34 (3): 337-346, 2008

11.Cheng, M., Li, Q., Lin, B., Sha, Y., Ren, J. H., He, Y., Wang, Q. H., Hua, H. M., and Ruud, K., Assignment of the absolute configuration of (-)-linarinic acid by theoretical calculation and asymmetric total synthesis. Tetrahedron-Asymmetry, 17 (2): 179-183, 2006