导师简介
导师姓名王思玲性别女出生年月1962.02导师类别硕导, 博导
研究方向溶性药物纳米分散制剂与大分子药物给药系统的研究
联系电话**职称/院士教授
E-mailwangslsy@163.com导师学位博士
学院（工作单位）药学院
信箱（地址）32号信箱

第一部分：个人情况介绍、概览

王思玲，女，博士，教授，1984年本科毕业留学任教，1999年赴日本近畿大学药学部访问，1999年和2004年被聘为沈阳药科大学副教授和教授，2007年赴牛津大学医学部高级访问学者。目前主要从事难溶性药物纳米分散制剂与大分子药物给药系统的研究。现任中国药学会药剂专业委员会委员，沈阳药科大学药剂学教授，辽宁省特聘教授，辽宁省现代药物制剂研究重点实验室主任；入选辽宁省“百千万人才工程”百人层次及辽宁省高校优秀人才资助计划。主持国家重大基础研究计划（973计划）课题与子课题各1项，国家自然科学基金4项及教育部博士点基金（博导类）等项目12项；在Bio, JCR, Carbon, Appl.Mater.Interf, NNBM, Biomacromolecules, EJPB及MP等学术杂志发表SCI收录论文80余篇，累计SCI影响因子约为252（其中第一作者或通讯作者60余篇，累计SCI影响因子为186）；获中国发明专利授权12项，获教育部科学技术进步一等奖1项，省自然科学学术成果一等奖4项，省科学技术二等奖1项、三等奖2项，省教学成果二等奖1项，市科学技术二等奖3项及三等奖1项；主编《物理药剂学》（中国化工出版社）与《胶体分散药物制剂》（人民卫生出版社）专著等。

第二部分：主持、参与的科研项目（含科研获奖等情况）

1.纳米技术增加难溶药物的水溶性及作用机理研究，编号2009CB930302，中国科技部国家重大基础研究计划（973计划），主持人

2.难溶性药物口服纳米制剂的体内转运机理及药效研究，编号2015CB932103，中国科技部国家重大基础研究计划（973计划），子课题主持人

3.“门控式”介孔二氧化硅难溶性药物递送系统与定位释放药物的机制，编号**，，国家自然科学基金，主持人

4.有序介孔碳载体调控难溶性药物释放与促进吸收的机制，编号**，国家自然科学基金，主持人

5.三维有序大孔二氧化硅纳米药物载体的构建及增加难溶性药物口服吸收的机制，编号**，国家自然科学基金，主持人

6.反义药物主动靶向传递体系，编号**，国家自然科学基金，主持人

7.辅酶Q10眼部药物传递系统及抗白内障机制，教育部高校博士点博导类基金，主持人

第三部分：近年来发表代表性论文或论著

论文代表作(影响因子大于3)：

1.Zhao H. Wang, Zhan Y. Wang, Chang S. Sun, Chun Y. Wang, Tong Y. Jiang, Si L. Wang. Trimethylated chitosan-conjugated PLGA nanoparticles for the delivery of drugs to the brain. Biomaterials,2010, (145): 257-263.（影响因子8.312）

2.Yanzhuo Zhang, Zhuangzhi Zhi, Tongying Jiang, Jinghai Zhang, Zhanyou Wang, Siling Wang. Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. Journal of Controlled Release. 2010, 31(5):908-915.（影响因子7.261）

3.Long Wan, Qinfu Zhao, Peng Zhao, Bing He, Tongying Jiang, Qiang Zhang,Siling Wang. system for the poorly water-soluble drug indomethacin. Carbon, 2014 (79) 123 – 134. (影响因子6.16)

4.Qinfu Zhao, Hongjian Geng, Ying Wang, Yikun Gao, Jiahao Huang, Yan Wang, Jinghai Zhang, Siling Wang. Hyaluronic Acid Oligosaccharide Modified Redox-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery. ACS Applied Maretials & Interfaces, 2014 ,6(22) 20290-20299. (影响因子5.9)

5.Lizhang Sun,Yanzhu Wang,Tongying Jiang,Xin Zheng,Jinghai Zhang,Jin Sun,Changshan Sun,and Siling Wang. Novel Chitosan-Functionalized Spherical Nanosilica Matrix As an Oral Sustained Drug Delivery System for Poorly Water-Soluble Drug Carvedilol. ACS Applied Maretials & Interfaces, 2013, 5, 103? 113. (影响因子5.9)

6.Yikun Gao,Zhan-You Wang,Jinghai Zhang,Youxi Zhang,Hong Huo,Tianyi Wang,Tongying Jiang, Siling Wang. RVG-Peptide-Linked Trimethylated Chitosan for Delivery of siRNA to the Brain. Biomacromolecules, 2014, 15, 1010-1018. (影响因子5.371)

7.Yanzhuo Zhang,Jiancheng Wang,Xiaoyu Bai,Tongying Jiang,Qiang Zhang, Siling Wang. Mesoporous Silica Nanoparticles for Increasing the Oral Bioavailability and Permeation of Poorly Water Soluble Drugs. molecular pharmaceutics, 2012, 9, 505?513(影响因子4.787)

8.Peng Zhao, Lihong Wang, Changshan Sun, Tongying Jiang, Jinghai Zhang, Qiang Zhang,Jin Sun, Yihui Deng, Siling Wang. Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study. European Journal of Pharmaceutics and Biopharmaceutics, 2012 , 80 : 535–543. (影响因子4.245)

9.Yanchen Hu, Zhuangzhi Zhi, Tianyi Wang, Tongying Jiang, Siling Wang. Incorporation of indomethacin nanoparticles into 3-D ordered macroporous silica for enhanced dissolution and reduced gastric irritancy. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 79: 544–551. (影响因子4.245)

10.Yanzhuo Zhang, Tongying Jiang, Qiang Zhang, Siling Wang. Inclusion of telmisartan in mesocellular foam nanoparticles: Drug loading and release property. European Journal of Pharmaceutics and Biopharmaceutics, 2010, (76) 1: 17-23. (影响因子4.245)

11.Ying Wang, Qinfu Zhao, Yanchen Hu, Lizhang Sun, Ling Bai, Tongying Jiang and Siling Wang. Ordered nano-porous silica as carriers for improved delivery of the water-insoluble drug: a comparative study between 3D macroporous silica and 2D mesoporous silica. International Journal of Nanomedicine, 2013:8 4015–4031. (影响因子4.195)

12.Qinfu Zhao, Chen Wang, Ying Liu, Jiahong Wang, Yikun Gao, Xiaojing Zhang, Tongying Jiang, Siling Wang. PEGylated mesoporous silica as a redox-responsive drug delivery system for loading thiol-containing drugs. International Journal of Pharmaceutics, 2014:477 613-622. (影响因子3.785)

13.Qiang Zhang, Qinfu Zhao, Ying Zhang, Ning Han, Liang Hu, Chen Zhang, Tongying Jiang, Siling Wang. Investigation of 3-D ordered materials with a high adsorption capacity for BSA and their potential application as an oral vaccine adjuvant. International Journal of Pharmaceutics, 2014, 434: 113–121. (影响因子3.785)

14.Chen Zhang,Qinfu Zhao,Long Wan, Tianyi Wang, Jin Sun,Yikun Gao,Tongying Jiang, Siling Wang. Poly dimethyl diallyl ammonium coated CMK-5 for sustained oral drug release. International Journal of Pharmaceutics, 461 (2014) 171– 180. (影响因子3.785)

15.Qiuping Ma,Hongrui Sun, Erxi Che, Xin Zheng, Tongying Jiang, Changshan Sun, Siling Wang. Uniform nano-sized valsartan for dissolution and bioavailability enhancement: Influence of particle size and crystalline state. International Journal of Pharmaceutics, 2013, 441: 75– 81. (影响因子3.785)

16.Xia Niu, Long Wan, Zhong Hou, Tianyi Wang, Changshan Sun, Jin Sun,Peng Zhao, Tongying Jiang, Siling Wang. Mesoporous carbon as a novel drug carrier of fenofibrate for enhancement of the dissolution and oral bioavailability. International Journal of Pharmaceutics, 2013, 452: 382-389. (影响因子3.785)

17.Chao Wu,Zhongyan Wang,Zhuangzhi Zhi, Tongy ing Jiang, Jinghai Zhang, Siling Wang. Development of biodegradable porous starch foam for improving oral delivery of poorly water soluble drugs. International Journal of Pharmaceutics, 2011, 403: 162-169. (影响因子3.785)

18.Siling Wang, Jing Zhang, Tongying Jiang, Li Zheng, Zhanyou Wang, Jinghai Zhang, Pan Yu. Protective effect of Coenzyme Q10 against oxidative damage in human lens epithelial cells by novel ocular drug carriers. International Journal of Pharmaceutics, 2011, (403): 219-229. (影响因子3.785)

19.Siling Wang, Tongying Jiang, Mingxin Ma, Yanchen Hu, Jinghai Zhang. Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting. International Journal of Pharmaceutics, 2010, 386(1-2): 249-255. (影响因子3.785)

20.Jing Zhang, SilingWang. Topical use of Coenzyme Q10-loaded liposomes coated with trimethyl chitosan: Tolerance, precorneal retention and anti-cataract effect. International Journal of Pharmaceutics, 2009, 372 (1-2): 66–75. (影响因子3.785)

21.Guanhao Ye, Siling Wang, Paul Wan Sia Heng, Ling Chen, Chao Wang. Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization. International Journal of Pharmaceutics, 2007, 337 (1-2): 80–87. (影响因子3.785)

22.Siling Wang, Lihua Cheng, Fengbo Yu, Weisan Pan, Jinghai Zhang. Delivery of different length poly(L-lysine)-conjugated ODN to HepG2 cells using N-stearyllactobionamide-modified. International Journal of Pharmaceutics, 2006,31: 82-88. (影响因子3.785)

23.Yanzhuo Zhang, Jinghai Zhang, Tongying Jiang, Siling Wang. Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: Drug loading and release properties. International Journal of Pharmaceutics, 2011, 410 (1-2): 118–124. (影响因子3.785)

24.Tongtong Ma, Lianyan Wang , Tingyuan Yang, Guanghui Ma, Siling Wang. PLGA-lipid liposphere as a promising platform for oral delivery of proteins. Colloids and Surfaces B:Biointerfaces, 2014, 117: 512-519. (影响因子3.607)

25.Qiang Zhang, Qinfu Zhao, Ying Zhang, Ning Han, Liang Hu, Chen Zhang, Tongying Jiang, Siling Wang. Investigation of 3-D ordered materials with a high adsorption capacity for BSA and their potential application as an oral vaccine adjuvant. Journal of Colloid and Interface Science, 2014, 434: 113-121. (影响因子3.552)

26.Yanchen Hu, Jing Wang, Zhuangzhi Zhi, Tongying Jiang, Siling Wang. Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug. Journal of Colloid and Interface Science, 2011, 363 : 410–417. (影响因子3.552)

27.Yanchen Hu, Zhuangzhi Zhi, Qinfu Zhao, Chao Wu, Peng Zhao, Haitao Jiang, Tongying Jiang,Siling Wang. 3D cubic mesoporous silica microsphere as a carrier for poorly soluble drug carvedilol. Microporous and Mesoporous Materials, 2012, 147 : 94–101. (影响因子3.209)

28.Haitao Jiang, Tianyi Wang, Lihong Wang, Changshan Sun, Tongying Jiang, Gang Cheng,Siling Wang. Development of an amorphous mesoporous TiO2 nanosphere as a novel carrier for poorly water-soluble drugs: Effect of different crystal forms of TiO2 carriers on drug loading and release behaviors. Microporous and Mesoporous Materials, 2102, 153 : 124–130. (影响因子3.209)

29.Peng Zhao, Haitao Jiang, Tongying Jiang, Zhuangzhi Zhi, Chao Wu, Changshan Sun,Jinghai Zhang, Siling Wang. Inclusion of celecoxib into ?brous ordered mesoporous carbon for enhanced oral bioavailability and reduced gastric irritancy. European Journal of Pharmaceutical Sciences, 2012, 45 : 639–647. (影响因子3.005)

第四部分：主编或参编的教材、专著

1.主编，《胶体分散药物制剂》，人民卫生出版社，2006

2.主编，《物理药剂学》，化学工业出版社，2004

第五部分：专利及其他

1.一种治疗消化性溃疡的复方片剂及其制备方法，中国发明专利，ZL**3.1，排名1，授权日12013-01-23

2.一种生物可降解球形多孔淀粉泡沫的制备方法与应用，中国发明专利，ZL**9.X，排名1，授权日2014-05-21

3.含有局麻药的复方异丙酚注射剂及制备方法，中国发明专利，ZL**2.1，排名1，授权日2012-05-30

4.缬沙坦喷雾干燥纳米混悬剂及其制备方法，中国发明专利，ZL**6.1，排名1，授权日2014-04-23。

5.伊曲康唑乳膏剂及其制备方法，中国发明专利，ZL**0.1，排名1，授权日2012-08-29。

6.口服胰岛素微粒剂及其制备方法，中国发明专利，ZL**.0，排名1，授权日2005-10-05。

7.伊曲康唑注射乳剂及其制备方法，中国发明专利，ZL**0.X，排名1，授权日2010-12-29。

8.一种高稳定性抗白内障药物，中国发明专利，ZL **.8，排名1，授权日2006-08-30。

9.一种溶菌酶眼用凝胶剂及其制备方法，中国发明专利，ZL **0.6，排名1，授权日2014-04-29。

10.醒脑静注射乳剂及其制备方法，中国发明专利，ZL **1，排名1，授权日2010-04-28。

第六部分：担任学术职务、社会兼职、人才称号以及个人获奖

1.辽宁省现代药物制剂研究重点实验室主任

2.辽宁省高校药物剂型设计与评价重点实验室主任

3.中国药学会药剂专业委员会委员

4.《沈阳药科大学学报》杂志常务编委

5.《亚洲药物制剂科学》（英文版）杂志编委

6.《世界临床药物》杂志编委

7.《中国生化药物》杂志编委

8.《中国药剂学杂志》杂志编委；

9.辽宁省特聘教授

10.辽宁省“百千万人才工程”百人层次

11.辽宁省教育厅优秀人才资助计划

12.辽宁省巾帼建国标兵

13.沈阳市优秀共产党员

14.沈阳市三八红旗手标兵

15.中国共产党沈阳市第十二次代表大会代表

16.中国共产党沈阳市第十一次代表大会代表等荣誉称号。