导师简介
导师姓名张向荣性别女出生年月1969.06导师类别硕导
研究方向药代动力学功能食品中有效成分的生物学研究
联系电话**/**职称/院士副教授
E-mailxrzhxr@126.com导师学位博士
学院（工作单位）中药学院
信箱（地址）51号信箱

张向荣, 1991年本科毕业于沈阳药学院，获学士学位，2000年毕业于沈阳药科大学获药剂硕士学位，2006年获药学博士学位。2010年3月到2010年8月在美国伯明翰阿拉巴马州大学、2010年9至2011年8月在美国德州理工大学博士后, 从事抗癌候选化合物的体内外生物活性评价, 进行动物体内药物动力学和体外肝微粒体代谢研究。应邀作为Chem Pharm Bull和Journal of Microencapsulation 等研究杂志审稿者。

主持项目：辽宁省教育厅：肿瘤靶向性纳米药物传递系统的研究（2008.01~2010.12）. 辽宁省科学技术基金: 人参果中抗癌单体25-OH-PPD长循环脂质体的研制(**)

主要参加项目：国家自然基金三项，国家“十五”重大科技专项：丹参酚酸类化合物抗心肌缺血构效关系研究。 “十一五”国家科技攻关重大专项： 一类抗肿瘤新药-新人参皂苷元AD-1的临床前研究。

研究方向：药代动力学/功能食品中有效成分的生物学研究

获奖：辽宁省自然科学学术成果奖三等奖2项.

编写著作：

1. 参译 ?药物生物利用度?（化学工业出版社）

2. 参编 ?物理化学实验?（中国医药科技出版社，本科生教材）

3. 参编 ?物理化学实验? (英汉对照，第一版)（人民卫生出版社，本科教材）

4. 参编 ?亚健康与保健食品概论?（科技出版社）

在国内外期刊发表教学和科研论文近40篇，其中被SCI收载15篇。代表文章如下：

1. Xiangrong Zhang, Hongxia Xu, Xu Zhang, Sukesh Voruganti, Preclinical Evaluation of Anticancer Efficacy and Pharmacological Properties of FBA-TPQ, a Novel Synthetic Makaluvamine Analog. Mar. Drugs. 2012, 10, 1138-1155

2. Jing Wang, Xiangrong Zhang et al. Development and evaluation of press-coated salbutamol sulfate tablet for delayed-release dosage forms. The Journal of Drug Delivery Science and Technology 2012, 22 (4) : 335-340

3. Haibo Li, Scharri J. Ezell, Xiangrong Zhang, Elizabeth R. Rayburn, Evrim Gurpinar, Charnell Sommers, Sadanandan E. Velu, Ruiwen Zhang＊. Development and Validation of a HPLC Method for Quantitation of BA-TPQ, a Novel Iminoquinone Anticancer Agent, and an Initial Pharmacokinetic Study in Mice. Biomedical Chromatography 2011; 25(5):628-634

4. Xiangrong Zhang, Xiaoning Ma, Bingkun Si, Yuqing Zhao＊. Simultaneous etermination of Five Active Hydrolysis Ingredients from Panax quinquefolium L. by HPLC-ELSD. Biomedical Chromatography 2011; 25(6):646-651.

5. Qiuhua Luo, Junming Zhao, Xiangrong Zhang, Weisan Pan. Nanostructured lipid carrier (NLC) coated with Chitosan Oligosaccharides and its potential use in ocular drug delivery system. Int J Pharm. 2011, 17; 403(1-2):185-9

6. Scharri J. Ezell , Haibo Li, Hongxia Xu, Xiangrong Zhang, Evrim Gurpinar, Ruiwen Zhang＊. Preclinical Pharmacology of BA-TPQ, a Novel Synthetic Iminoquinone Anticancer Agent. Mar. Drugs 2010, 8(7), 2129-2141

7. Xiangrong Zhang, Jinghua Xu, Dan Zhang, Jingkai Gu , Yuqing Zhao. The study of pharmacokinetics of 20(S)-25-methoxyl-dammarane-3?, 12?, 20-triol and its active metabolite after oral and intravenous administration in rat. Xenobiotica 2009, 39(6): 457–464

8. Xiangrong Zhang, Yifan Zhang, Jing Wang, Haibo Zhou, Sanming Li, Dafang Zhong. Pharmacokinetics of clarithromycin citrate salt after oral administration to beagle dogs and food effect on its absorption . PDA journal of Pharmaceuical Science and Technology. 2008，62 （6）445-453

9. Xiangrong Zhang, Juanmei Zhou, Xiaoyan Chen, Sanming Li, Dafang Zhong. Bioavailability of clarithromycin acid-cyclodextrins ternary complexes upon oral administration to healthy beagle dogs. Drug Development and Industrial Pharmacy.2008; 34 (10):1048-1053.

10. Xiang-Rong Zhang,Yi-Fan Zhang,Jing Wang,Hai-Bo Zhou, San-Ming Li,and Da-Fang Zhong. Pharmacokinetics of Clarithromycin Citrate Salt after Oral Administration to Beagle Dogs and Food Effects on Its Absorption. PDA J Pharm Sci Technol November/December 2008 62:445-453.

11. Ma Ninan, Xu Lu, Wang Qifang, Zhang Xiangrong, Li Sanming. Development and evaluation of new sustained-release floating microspheres. Int J Pharm. 2008; 358 (1-2):82-90 (SCI)

12. Xiangrong Zhang, Dan Zhang, Jinghua Xu, Jingkai Gu and Yuqing Zhao. Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies. Journal of Chromatography B, 2007, 858 (15): 65-70.

13. Xiangrong Zhang, Ying Chen, Yifan Zhang, Sanming Li, Dafang Zhong. Investigation and physicochemical characterization of clarithromycin?citric acid?cyclodextrins ternary complexes. Drug Development and Industrial Pharmacy. 2007, 33(2):163–171.

14. Xiangrong Zhang , Yanjiao Wang, Jing Wang, Yan Wang, Sanming Li. Effect of pore former on the properties of casted film prepared from blends of Eudragit NE 30 D and Eudragit L 30 D-55. Chem Pharm Bull (Tokyo). 2007; 55(8):1261-1263.

15. Xiangrong Zhang, Xiaoyan Chen, Liandong Hu, Sanming Li, Xing Tang, Dafang Zhong. Evaluation of In-vitro dissolution and In-vivo absorption for two different film-coated pellets of clarithromycin. Archives of Pharmacal Research. 2005, 28(8): 977-982.

16. Xiangrong Zhang, Xiaoyan Chen, Xiaoyan Li, Dafang Zhong. Determination of clarithromycin in human plasma by liquid chromatography tandem mass spectrometry: validation and application in clinical pharmacokinetic study. Journal of Chinese Pharmaceutical Sciences. 2004, 13(6): 166-170.

17 王岩, 张向荣 等.氟比洛芬肠溶微球的制备与影响因素考察.中国药剂学杂志. 2012, 10(3): 50-54

18. 孙运栋, 张向荣,等. 枸橼酸莫沙必利口腔崩解片的制备及评价.沈阳药科大学学报. 2009 (26):176-180

19. 周海波, 张向荣, 王岩, 李三鸣 等. 氟比洛芬羟丙基-β-环糊精包合物的研制. 中国医院药学杂志. 2008(18):1539-1541

20. 张向荣, 王晶, 周海波等. 盐酸环丙沙星-聚氰基丙烯酸正丁酯纳米溶胶的制备. 中国新药杂志. 2007(24):2054-2056

21. 李红菊，张向荣，刘洪卓等. 丙烯酸树脂RS100和丙烯酸树脂RL100混合包衣制备法莫替丁渗透泵控释片. 沈阳药科大学学报. 2007(7):398-401

22. 张向荣, 张逸凡, 钟大放. 体外Caco-2细胞模型在药物吸收中的应用进展. 中国医院药学杂志. 2004, 4 (12): 773-775

23. 张向荣, 陈笑艳, 唐星, 钟大放. 克拉霉素缓释胶囊释放度与体内吸收度相关性的研究. 药物分析杂志. 2004 (5):509-512

24. 张向荣, 王岩等. 总丹酚酸胃内滞留缓释片的研制. 中成药, 2003, 25(5)：349-351

25. 张向荣, 潘卫三. HPLC法测定大鼠血浆中丹参酚酸A的浓度. 中草药, 2002,33(5):410-411