导师简介
导师姓名刘洪卓性别女出生年月1979.04导师类别硕导
研究方向治疗药物性耳聋靶向纳米制剂的研究；有机原位凝胶控释给药系统研究；眼部给药系统研究等
联系电话**职称/院士副教授
E-mailbby_1979@163.com导师学位博士
学院（工作单位）药学院
信箱（地址）23号

导师姓名：刘洪卓

性别：女

出生年月：1979.04

导师类别：硕导

研究方向：治疗药物性耳聋靶向纳米制剂的研究；有机原位凝胶控释给药系统研究；眼部给药系统研究等

联系电话：**

职称：副教授

E-mail：bby_1979@163.com

导师学位：博士

学院：药学院

信箱：23号

【概况】

刘洪卓，女，药剂学博士，副教授，硕士生导师。2002年07月本科毕业于沈阳药科大学药学院日语药学专业；2002年9月至2007年6月硕博连读，获得博士学位，后留校任教至今。2010年8月到2012年1月赴美国辛辛那提大学药学院在S. Kevin Li教授的指导下从事博士后研究工作。

主要研究方向为治疗药物性耳聋靶向纳米制剂的研究；有机原位凝胶控释给药系统研究；眼部给药系统研究等。目前主持包括2项国家自然科学基金在内多个纵向课题，在国内外学术期刊发表研究论文47篇，其中SCI 收录25篇。获辽宁省自然科学学术优秀成果奖一等奖1项、三等奖2项，博士论文获辽宁省优秀博士学位论文，全国优秀博士学位论文提名奖，入选辽宁省高等学校杰出青年学者成长计划。

【学术兼职】

1.沈阳药科大学学报，编委

2.Asian Journal of Pharmaceutical Sciences，主编助理

3.Int J Pharm, J Pharm Sci, Expert Opinon on Drug Delivery等多个杂志的审稿人

【主持、参与科研项目】

1.国家自然科学基金青年基金项目，神经性耳聋治疗新模式：载神经营养因子类脂立方晶内耳给药系统的研究，主持

2.国家自然科学基金面上基金项目, 非膜电位依赖型线粒体靶向传递策略：治疗药物性耳聋，主持

3.2014年度辽宁省高等学校杰出青年学者成长计划，主持

4.2014年度沈阳药科大学中青年发展支持计划，主持

5.国家自然科学基金面上基金项目，超分子生物降解有机原位凝胶协同释药传递系统的构建机理及其应用基础研究，主要参与人

6.国家自然科学基金面上基金项目，新型潜在药物载体离子交换纤维性质和释药特征的基础研究和评价，主要参与人

7.国家自然科学基金面上基金项目，自组装有机原位注射植入凝胶在蛋白类药物长效传递系统的研究，主要参与人

【近年发表的代表性论文】

1.Che Xin, Wang Lihong, Li Qiuyuan, Liu Hongzhuo＊, Injectable long-term control-released in situ gels of hydrochloric thiothixene for the treatment of schizophrenia: Preparation, in vitro and in vivo preparation. Int J Pharm, 469(1): 23-30, 2014 (SCI, IF=3.7)

2.Hongzhuo Liu, Michael B. Yang, S. Kevin Li and Jinsong Hao, Effects of Dosing Protocol on Distribution of Propranolol in Periocular Tissues after Topical Ocular Instillation, Current Eye Research, DOI: 10.3109/**.2014.952830, 2014, (SCI, IF=1.5)

3.Hongzhuo Liu, Yan Ma, Dan Liu, John K. Fallon, Feng Liu, The Effect of Surfactant on Paclitaxel Nanocrystals: In Vitro and In Vivo. J Biomed Nanotechnol, 2013, accepted. (SCI, IF=7.2)

4.Hongzhuo Liu, Yanyan Zhou, Shichao Chen, Meng Bu, Jiayu Xin, Sanming Li. Current Sustained Delivery Strategies for the Design of Local Neurotrophic Factors in Treatment of Neurological Disorders. Asian Journal of Pharmaceutical Sciences, 2013, doi:10.1016/j.ajps.2013.10.003.

5.Hongzhuo Liu＊, Yan Wang, Qifang Wang, Zhen Li, Yanyan zhou, Yusheng Zhang and Sanming Li. Protein-bearing cubosomes prepared by liquid precursor dilution: inner ear delivery and pharmacokinetics study following intratympanic administration. J Biomed Nanotechnol, 2013, 9: 1784-1793.(SCI, IF=7.2)

6.Hongzhuo Liu, Shichao Chen, Yanyan Zhou, Xin Che, Zhihong Bao, Sanming Li and Jinghua Xu. The effect of surface charge of glycerol monooleate based nanoparticles on the round window membrane permeability and cochlear distribution. Journal of Drug Targeting, 2013, 21(9):846-854.(SCI, IF=2.8)

7.Hongzhuo Liu＊, Jinsong Hao and S.Kevin Li. Current Strategies for Drug Delivery to the Inner Ear. Acta Pharmaceutica Sinica B, 2013; 3(2):86-96.

8.Hongzhuo Liu, Liang Feng, Gaurav Tolia, Mark R.Liddell, Jinsong Hao and S. Kevin Li. Evaluation of intratympanic formulations for inner ear delivery: methodology and sustained release formulation testing. Drug Dev Ind Pharm, 2013, doi:10.3109/**.2013.789054.(SCI, IF=1.5)

9.Hongzhuo Liu, Kuimao Shang, Weina Liu, Donglei Leng, Ran Li, Ying Kong, Tianhong Zhang. Improved oral bioavailability of glyburide by a self-nanoemulsifying drug delivery system. Journal of Microencapsulation, 2013, accepted. (SCI, IF=1.4)

10.Zhou Yanyan, Wang Qifang, Wangyan, Xu Hui, Yuan Bo, Li Sanming and Liu Hongzhuo＊. Biological artificial fluid-induced non-lamellar phases in glyceryl monooleate: the kinetics pathway and its digestive process by bile salts. Drug Dev Ind Pharm, 2013, Jan 25. doi:10.3109/**.2012.752502(SCI, IF=1.5)

11.Liu Hongzhuo, Xu Hui, Wang Yongjun, He Zhonggui and Li Sanming. Effect of intratumoral injection on the biodistribution and therapeutic potential of novel chemophor EL-modified single-walled nanotube loading doxorubicin. Drug Dev Ind Pharm, 2012, 38:1031-8.(SCI, IF=1.5)

12.Wang Yongjun, Xu Hui, Liu Hongzhuo, Wang Yan, Sun Jin and He Zhonggui. Efficacy and biodistribution of tocopheryl polyethylene glycol succinate noncovalent functionalized single walled nanotubes loading doxorubicin in sarcoma bearing mouse model. J Biomed Nanotechnol, 2012, 8:450-7.(SCI, IF=7.2)

13.Jinsong Hao, Michael B. Yang, Hongzhuo Liu, and S. Kevin Li. Distribution of Propranolol in Periocular Tissues: A Comparison of Topical and Systemic Administration. Journal of Ocular Pharmacology and Therapeutics, 2011, 27: 453-459.(SCI, IF=1.7)

14.Liu Hongzhuo, Wang Yongjun, Xu Lu and Li Sanming. Investigation into the Potential of Electroporation Facilitated Topical Delivery of Cyclosporin A. PDA Journal of Pharmaceutical Science and Technology, 2010, 64:191-199

15.Liu Hongzhuo, Wang Yongjun, Lang Yiyong, Yao Huimin, Dong Yang, Li Sanming. Bicontinuous cyclosporin A loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo. J Pharm Sci, 2009, 98:1167-76.(SCI, IF=3.0)

16.Liu Hongzhuo, Wang Yongjun, Li Sanming. Advanced delivery of Cyclosporin A: current state and perspective. Expert Opinion on Drug Delivery, 2007, 4(4):349-358

17.Liu Hongzhuo, Wang Yongjun, Han Fei, Yao Huimin, Li Sanming. Gelatin-stabilised microemulsion-based organogels facilitates percutaneous penetration of Cyclosporin A in vitro and dermal pharmacokinetics in vivo. J Pharm Sci, 2007, 96(11):3000-3008.(SCI, IF=2.9)

18.Liu Hongzhuo, Li Sanming, Wang Yongjun, Yao Huimin, Zhang Yan, Effect of vehicles and enhancers on the topical delivery of cyclosporin A. Int J Pharm, 2006; 311: 182–186.(SCI, IF=3.3)

19.Liu Hongzhuo, Li Sanming, Pan Weisan, Wang Yongjun, Han Fei, Yao Huimin. Investigation into the potential of low-frequency ultrasound facilitated topical delivery of Cyclosporin A. Int J Pharm, 2006; 326: 32-38. (SCI, IF=3.3)

20.Liu Hongzhuo, Li Sanming, Wang Yongjun, Han Fei, Dong Yang. Bicontinuous water-AOT/Tween85-isopropylmytistate microemulsion: a new vehicle for transdermal delivery of Cyclosporin A. Drug Dev Ind Pharm, 2006; 32: 549-557.(SCI, IF=1.0)