导师简介
导师姓名韩福社性别男出生年月1970.10导师类别硕导
研究方向天然物合成、药物合成、不对称催化、过渡金属催化的偶联方法学等机合成
联系电话**职称/院士研究员
E-mailfshan@ciac.ac.cn导师学位博士
学院（工作单位）中国科学院长春应用化学研究所
信箱（地址）吉林省长春市人民大街5625号

韩福社，男，中国科学院长春应用化学研究所研究员，博士生导师，中科院“百人计划”获得者。主要研究方向为天然物合成、药物合成、不对称催化、过渡金属催化的偶联方法学等。　迄今在Chem. Soc. Rev.、J. Am. Chem. Soc.、Adv. Mater.、Chem. Commun.、Org. Lett.、Chem. Eur. J.、Adv. Synth. Catal.、ChemCatChem等发表文章60余篇，其中影响因子大于5的30余篇；申请专利13项，其中已授权7项。吉林省化学会有机化学专业委员会副主任；吉林省药学会药物化学专业委员会委员。

主要学习工作经历：

1989.9-1993.7 重庆大学化工学院精细化工专业，本科。期间获香港社会福利基金会华新奖学金。

1993.9-1996.7 大连理工大学化工学院有机化学系，硕士研究生；1996年获辽宁省教育厅科技进步二等奖。

1996.9-1999.9 中科院长春应化所有机和高分子室，博士研究生；中科院优秀博士毕业生，获伟华科技一等奖学金。

1999.10-2001.7 中科院上海有机所生命有机室博士后 （马大为教授组）。

2001.8-2003.3 日本Ehime 大学工学部应用化学科博士后 （Yutaka Watanabe 教授）；日本文部省Venture Business Laboratory (VBL) 特别研究员基金。

2003.4-2006.3 东京大学药学部天然物合成化学科，科学技振兴机构（JST）研究员（Tohru Fukuyama 教授）；日本科学技术振兴机构（JST） PRESTO研究员基金。

2006.4-2008.7 日本国立物质材料研究机构，有机纳米中心，博士研究员（合作者：Dirk G. Kurth博士，德国Max-Planck 研究所；Masayoshi Higuchi 博士，物质材料研究机构）；

2008.8-今, 中科院长春应用化学研究所，研究员/博导/“百人计划”获得者。

主要承担项目：

1） 国家自然科学基金面上项目

2） 中科院“百人计划”项目

3） 中科院天然产物合成化学重点实验室开放课题基金

4） 生命有机化学国家重点实验室开放课题基金

5） 精细化工国家重点实验室开放课题基金

代表性论文（第一作者或通讯联系人）：

1) F. Han,＊ “Transition-Metal-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: A Remarkable Advance from Palladium to Nickel Catalysts”, Chem. Soc. Rev., 2013, 42, 5270. (Invited review). (IF = 30.425)

2) F. Han, M. Higuchi, D. G. Kurth, “Metallo-Supramolecular Polymers Based on Functionalized Bis-terpyridines as Novel Electrochromic Materials” Adv. Mater., 2007, 19,3928. (IF = 15.409)

3) Z.-J. Du, J. Guan, G.-J. Wu, P. Xu, L.-X. Gao, F.-S. Han,＊ “Palladium-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C–H Arylation”, J. Am. Chem. Soc., 2015, 137, 632. (IF = 11.444)

4) F. Han, M. Higuchi, D. G. Kurth, “Metallo-Supramolecular Polyelectrolytes Self-assembled from Various Pyridine Ring Substituted Bis-terpyridines and Metal Ions: Photophysical, Electrochemical and Electrochromic Properties” J. Am. Chem. Soc., 2008, 130, 2073. (IF = 11.444)

5) X. Zhong, Y. Li, W.-X. Zhang, J. Zhang, S.-X. Wang, F.-S. Han,＊ “Formal [3+3] Cyclization of Indol-2-yl Carbinol with Aza-Diene and the Subsequent Oxidative Ring Expansion Reaction for the Synthesis of Indole Azepinones”, Chem. Commun., 2014, 50, 11181. (IF = 6.718)

6) S. Qi, C.-Y. Liu, J.-Y. Ding, F.-S. Han,＊ “Chiral Phosphoramide-Catalyzed Enantioselective Synthesis of 2,3’-Diindoylarylmethanes from Indol-2-yl Carbinol and Indole”, Chem. Commun., 2014, 50, 8605. (IF = 6.718)

7) Y.-L. Zhao, G.-J. Wu, F. Han＊, “Ni-Catalyzed Construction of C–P Bond from Electron-deficient Phenols via the in situ Aryl C–O Activation by PyBroP”, Chem. Commun., 2012, 48, 5868. (IF = 6.718)

8) Y. Li, L.-X. Gao, F. Han＊, “Efficient Synthesis of 2,5-Disubstituted Tetrazoles via the Cu2O-Catalyzed Aerobic Oxidative Direct Cross-coupling of N-H Free Tetrazoles with Boronic Acids”, Chem. Commun., 2012, 48, 2719. (IF = 6.718)

9) S.-M. Li, J. Huang, G.-J. Chen, F. Han＊, “PdCl2(dppf)-Catalyzed in situ Coupling of 2-Hydroxypyridines with Aryl Boronic Acids Mediated by PyBroP and the one-pot Chemo- and Regioselective Construction of two Distinct Aryl-Aryl Bonds”, Chem. Commun., 2011, 47, 12840. (IF = 6.718)

10) F.-Q. Yuan, L.-X. Gao, F. Han＊, “PdCl2-Catalyzed Efficient Allylation and Benzylation of Heteroarenes under Ligand, Base/Acid, and Additive-Free Conditions”, Chem. Commun., 2011, 47, 5289. (IF = 6.718)

11) F. Han, H. Tokuyama, T. Fukuyama, “Design and Synthesis of Thiazoline-Thiazole Hybrid Macrocycles Possessing Strong Affinity to Pb2+ and Cd2+” Chem. Comm., 2007, 3444. (IF = 6.718)

12) F. Han, H. Osajima, M. Cheung, H. Tokuyama, and T. Fukuyama, “Synthesis of Chiral Cyclic Oligothiazolines: A Novel Structural Motif for a Macrocyclic Molecule”, Chem. Comm. 2006, 1757-1759. (IF = 6.718)

13) F. Han, M. Higuchi, T. Ikeda, Y. Negishi, T. Tsukuda, D. G. Kurth, “Luminescence Properties of Metallo-supramolecular Coordination Polymers Assembled from Pyridine Ring Functionalized Ditopic Bis-terpyridine and Ru(II) ions” J. Mater. Chem., 2008, 18, 4555. (IF = 6.626)

14) Z. Xue, Y. Li, J. Zhang, F.-S. Han,＊ “Synthetic Study Toward the Misassigned (±)-Tronoharine”, Org. Lett., 2015, 17, 720. (IF = 6.324)

15) H. Xu, P.-T. Liu, Y.-H. Li, F.-S. Han,＊ “Copper-Mediated Direct Aryl C–H Cyanation with Azobisisobutyro-nitrile via a Free-radical Pathway”, Org. Lett., 2013, 15, 3354. (IF = 6.324)

16) F.-Q. Yuan, F. Han＊, “Synthesis of Densely Substituted ?,?,?,?-Dienones via the PdII-Catalyzed Allylation, H-Migration, and Aerobic Oxidative ?-Hydride Elimination Cascade”, Org. Lett., 2012, 14, 1218. (IF = 6.324)

17) F. Han, M. Higuchi, D. Kurth, “Diverse Synthesis of Novel Bisterpyridines via Suzuki-Type Cross-Coupling” Org. Lett., 2007, 9, 559-562. (IF = 6.324)

18) J. Guan, G.-J.Wu, F.-S. Han,＊ “Pd(II)-Catalyzed Mild C–H ortho Arylation and Intramolecular Amination Oriented by Phosphinamide Group”, Chem. Eur. J., 2014, 20, 3301. (IF = 5.696)

19) C.-Y. Liu, Y. Li, J.-Y. Ding, D.-W. Dong, F.-S. Han,＊ “The Development of Copper-Catalyzed Aerobic Oxidative Coupling of H-Tetrazoles with Boronic Acids and an Insight into the Reaction Mechanism”, Chem. Eur. J., 2014, 20, 2373. (IF = 5.696)

20) X. Zhong, Y. Li, F. Han＊, “Al-Catalyzed Facile Construction of Quaternary C–C Bonds via the Allylic Substitution of tertiary Alcohols: A Concise Formal Synthesis of (±)-Mersicarpine”, Chem. Eur. J., 2012, 18, 9784. (IF = 5.696)

21) Y.-L. Zhao, G.-J. Wu, Y. Li, L.-X. Gao, F. Han＊, “Ni(dppp)-Catalyzed Cross-coupling of Aryl Halides with Dialkylphosphite, Diphenylphosphine oxide, and Diphenylphosphine”, Chem. Eur. J., 2012, 18, 9622. (IF = 5.696)

22) G. J. Chen, J. Huang, L. X. Gao, F. Han＊, “Ni-Catalyzed Cross-Coupling of Phenols and Aryl Boronic Acids via an in situ Phenol Activation Mediated by PyBrOP”, Chem. Eur. J., 2011, 17, 4038. (IF = 5.696)

23) Y. Li, L. X. Gao, F. Han＊, “Reliable and Diverse Synthesis of Aryl Azides via Copper-Catalyzed Coupling of Boronic Acids/Esters with TMSN3”, Chem. Eur. J., 2010, 16, 7969. (IF = 5.696)

24) Y. L. Zhao, Y. Li, Y. Li, L. X. Gao, F. Han＊, “Aryl Phosphoramides: Useful Electrophiles for Suzuki?Miyaura Coupling Catalyzed by NiCl2/dppp System”, Chem. Eur. J., 2010, 16, 4991. (IF = 5.696)

25) F. Han, H. Osajima, M. Cheung, H. Tokuyama, and T. Fukuyama, “Novel Structural Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity” Chem. Eur. J. 2007, 13,3026 (Selected as inside cover page). (IF = 5.696)

26) F.-Q. Yuan, F. Han＊, “Iron-Catalyzed Direct Synthesis of Densely Substituted Benzofurans and Naphthopyrans from Phenolic Compounds and Propargylic Alcohols” Adv. Synth. Catal., 2013, 355, 537. (IF = 5.542)

27) Y.-L. Zhao, Y. Li, S.-M. Li, Y.-G. Zhou, F.-Y. Sun, L.-X. Gao, F.-S. Han＊, “A Highly Practical and Reliable Nickel Catalyst for Suzuki-Miyaura Coupling of Aryl Halides” Adv. Synth. Catal., 2011, 353, 1543. (IF = 5.542)

28) H. Gao, Y. Li, Y. G. Zhou, F. Han,＊ Y. J. Lin＊, “Highly Efficient Suzuki-Miyaura Coupling of Aryl Tosylates and Mesylates Catalyzed by Stable, Cost-effective [1,3-Bis(diphenylphosphino)propane]nickel(II) Chloride {Ni(dppp)Cl2} with only 1 mol ％ Loading”, Adv. Synth. Catal., 2011, 353, 309. (IF = 5.542)

29) Z.-J. Du, L.-X. Gao, Y.-J. Lin, F.-S. Han,＊ “Cu-Mediated Direct Aryl C–H Halogenation: a Strategy to Control Mono- and Di-Selectivity”, ChemCatChem, 2014, 6, 123. (IF = 5.044)

30) G.-J. Wu, J. Guan, F.-S. Han,＊ Y.-L. Zhao,＊ “Palladium-Catalyzed Silver-Mediated α-Arylation of Acetic acid: A New Approach for the α-Arylation of Carbonyl Compounds”, ChemCatChem, 2014, 6, 1589. (IF = 5.044)

授权专利 （第一发明人）：

1）韩福社，高连勋，赵玉龙，一种联芳烃类和双烯烃类化合物的制备方法，2012.9，中国，ZL **0.7

2)　韩福社，李水明，孙凤一，一种氨基联苯的制备方法，2013.12，中国，ZL **6.6

3) 韩福社，高连勋，赵玉龙，一种镍类催化剂在铃木偶联反应中的应用，2013.11，中国，ZL **7.3

4）F. Han, M. Higuchi, D. G. Kurth, “Synthesis of symmetrical or asymmetrical bis(terpyridine) compound used for polymer used as electrochromic material and display material such as electronic paper, involves carrying out coupling reaction of terpyridine compound”, JP **-A.

5）F. Han, M. Higuchi, D. G. Kurth, “Manufacture of bis(terpyridine) compound for electro-chromic material, electronic paper for display devices and electrochromic multicolorization, involves performing coupling reaction of terpyridine compounds and boron compound”, JP**-A.

6）F. Han, M. Higuchi, D. G. Kurth, “Synthesis of spacer introduction bis(terpyridine) compound used as electrochromic material for display device such as electronic paper, involves coupling two or more terpyridine compound with boron compound”, JP**-A.