职 称：讲师
办公电话：
电子邮件：yangzhe@lnu.edu.cn
教育背景
2014.09 ~ 2017.06 南开大学生命科学学院生物化学与分子生物学专业，博士学位2012.09 ~ 2014.06 南开大学生命科学学院生物工程专业，硕士学位
2007.09 ~ 2011.06 大连医科大学生物技术系生物技术专业，学士学位
工作经历
2018年至今辽宁大学生命科学院任教讲授课程
分子生物学基因工程
研究兴趣
肿瘤分子生物学细胞生物学
肿瘤发生发展分子机制
奖励荣誉--> -->
主要课题
国家自然科学基金青年项目，《MicroRNA-145通过影响RNA甲基化水平促进肝癌细胞抑癌基因表达的作用及其分子机制的研究》，2019.1.1-2021.12.31，**，25万元，在研，项目主持人学术成果
1、Yang, Z., Jiong Li, Guoxing Feng, Yuan Wang, Guang Yang, Yunxia Liu, Shuqin Zhang, Jinyan Feng,Xiaodong Zhang, Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b（2019）Cancer Biology & Medicine 二区 IF=4.6072、Yang, Z., Li, J., Feng, G., Liu, Y., Zhang, S., Ye, L., Zhang, W., and Zhang, X. MicroRNA-145 Modulates N-6-Methyladenosine Levels by Targeting the 3 '-Untranslated mRNA Region of the N-6-Methyladenosine Binding YTH Domain Family 2 Protein. (2017) JOURNAL OF BIOLOGICAL CHEMISTRY 二区 IF=4.258
3、Zhang S.,Yang, Z.(co-author), Cai, X., Zhao, M., Sun, M., Li, J., Feng, G., Wang Y., Feng, J., Ye, L., Zhang X. MiR-511 Promotes Proliferation of Hepatoma Cells viaTargeting theB CellTranslocation Gene 1 (BTG1) mRNA. (2017) Acta pharmacologica Sinica 二区IF=3.223.
4、Feng, G., Li, J., Yang, Z., Liu, Y., Zhang, S., Ye, L., Zhang, W., and Zhang, X. Hepatitis B virus X Protein Promotes the Development of Liver Fibrosis and Liver Cancer through Up-regulation of Prolyl 4-Hydroxylase Subunit Alpha 2.(2017) Oncogene IF=7.932
5、Wang Y, Chen F, Zhao M, Yang, Z, Li J, Zhang S, Zhang W, Ye L, Zhang X. (2017) The long noncoding RNA HULC promotes liver cancer by increasing the expression of the HMGA2 oncogene via sequestration of the microRNA-186.(2017) JOURNAL OF BIOLOGICAL CHEMISTRY IF=4.258
6、Wang Y, Chen F, Yang, Z, Zhao M, Zhang S, Gao Y, Feng J, Yang G, Zhang W, Ye L, Zhang X. (2017) The Fragment HMGA2-sh-3p20 from HMGA2 mRNA 3'UTR Promotes the Growth of Hepatoma Cells by Upregulating HMGA2..(2017) Scientific Reports IF=4.259
7、Feng, G., Li, J., Zheng, M., Yang, Z., Liu, Y., Zhang, S., Ye, L., Zhang, W., and Zhang, X. (2016) Hepatitis B virus X protein up-regulates C4b-binding protein alpha through activating transcription factor Sp1 in protection of hepatoma cells from complement attack. Oncotarget IF= 5.008
8、Lu, Z. P., Xiao, Z. L., Yang, Z., Li, J., Feng, G. X., Chen, F. Q., Li, Y. H., Feng, J. Y., Gao, Y. E., Ye, L. H., and Zhang, X. D. (2015) Hepatitis B virus X protein promotes human hepatoma cell growth via upregulation of transcription factor AP2alpha and sphingosine kinase 1. Acta pharmacologica Sinica IF=3.166.
9、Feng, G., Shi, H., Li, J., Yang, Z., Fang, R., Ye, L., Zhang, W., and Zhang, X. (2016) MiR-30e suppresses proliferation of hepatoma cells via targeting prolyl 4-hydroxylase subunit alpha-1 (P4HA1) mRNA. Biochemical and biophysical research communications IF=2.371
1110、Lu, Z., Xiao, Z., Liu, F., Cui, M., Li, W., Yang, Z., Li, J., Ye, L., and Zhang, X. (2016) Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1). Oncotarget IF=5.008
11、Gao Y, Wang Y, Feng J, Feng G, Zheng M, Yang, Z, Xiao Z, Lu Z, Ye L, Zhang X. A hairpin within YAP mRNA 3'UTR functions in regulation at post-transcription level. Biochem Biophys Res Commun. 2015 Apr 3;459(2):306-12 IF=2.371
