姓名赵龙铉 性别男
职称教授 学位博士
联系电话-
移动电话**
电子邮箱lxzhao@lnnu.edu.cn or lxzhaos@163.com
联系地址辽宁大连沙河口区黄河路850号辽宁师范大学化学化工学院
学习经历
11986.09 至 1993.07 延边大学化学系 学士、硕士
21997.03 至 2001.02 韩国岭南大学药学院 博士
32001.11 至 2003.10 韩国国立化学研究院感染症研究中心 博士后
工作经历
11993.08 至 1997.02 延边大学药学院 助教、讲师
22001.03 至 2001.10 韩国岭南大学附属药品开发研究所 访问研究员
32005.01 至 2005.12 韩国梨花女子大学 访问教授
42003.08 至 2009.06 辽宁师范大学化学化工学院 副教授
52009.07 至 今 辽宁师范大学化学化工学院 教授
个人概况
有机研究所所长，民进辽宁师范大学基层委员会 主委
社会兼职：政协沙河口区第九届委员、民进大连市委会第十三届委员、辽宁省青年联合会第九届委员

论文
1郭永泰, 侯熙彦, 郑昌吉, 赵春晖, 金宇婷, 高雪琴, 王倩, 孙蕾, 赵龙铉, 朴花, 新型异甜菊醇衍生物的合成、表征及生物活性研究, 有机化学, 2019, 39(12),3532-3541, DOI: 10.6023/cjoc
2金宇婷, 支德福, 郭永泰, 隋悦, 孙蕾, 王倩, 赵龙铉, 赵春晖, 酚类衍生物的美白和抗氧化活性, 应用化学, 2019, 36(11), 1257-1265
3刘新宇, 高雪琴, 金学军, 赵春晖, 冯中华, 隋 悦, 赵龙铉, 阎 欣, 新型齐墩果酸和熊果酸衍生物的合成、表征及细胞毒活性研究, 有机化学, 2018, 38(12), 3227-3235, DOI: 10.6023/cjoc
4J Yoon, D B Jarhad, G Kim, A Nayak, L X Zhao, et al. Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and — pyrimidines, European Journal of Medicinal Chemistry, 2018, 155, 406-417; DOI: 10.1016/j.ejmech.2018.06.003
5孙竞阳, 冯中华, 侯熙彦, 田甜, 刘新宇, 赵龙铉, 赵春晖, 熊果苷类似物的合成、表征及美白活性, 中国药物化学杂志, 2017,27(4), 267-273; DOI: 10.14142/j.cnki.cn21-1313/r.2017.04.002
6J Yu, L X Zhao, J Park, H W Lee, P K. Sahu, M Cui, S M. Moss, E Hammes, E Warnick, Z G Gao, M Noh, S Choi, H C Ahn, J Choi, K A Jacobson, and L S Jeong, N6-Substituted-5'-N-Methylcarbamoyl-4'-selenoadenosines as Potent and Selective A3 Adenosine Receptor Agonists with Unusual Sugar Puckering and Nucleobase Orientation, Journal of Medicinal Chemistry, 2017, 60(8), 3422-3437, DOI: 10.1021/acs.jmedchem.7b00241
7T Tian, X Y Liu, E S Lee, J Y Sun, Z H Feng, L X Zhao, C H Zhao, Synthesis of Novel Oleanolic Acid and Ursolic Acid in C-28 Position Derivatives as Potential Anticancer Agents, Archives of Pharmacal Research, 2017,40(4), 458-468, DOI: 10.1007/s12272-016-0868-8
8C H Zhao, P H Zhao, B Feng, X Y Hou , L X Zhao, Discovery and synthesis of amino acids modified deoxycholic acid derivatives and in vitro antiproliferative evaluation, Chemical & Pharmaceutical Bulletin, 2017,65(3), 276-283, DOI: 10.1248/cpb.c16-00836
9S Qu, V A Mulamoottil, A Nayak, S. Ryu, X Hou, J Song, J Yu, P K. Sahu, L X Zhao, S Choi, S K Lee, L S Jeong, Design, Synthesis, and Anticancer Activity of C8-Substituted-4’-Thionucleosides as Potential HSP 90 Inhibitors, Bioorganic & Medicinal Chemistry, 2016, 24(16), 3418-3428
10李 常, 孙竞阳, 支德福, 田甜, 陈艳华, 赵龙铉, 赵春晖; 酚类糖苷缀合物的合成、表征及美白活性, 应用化学, 2016, 33(7), 780-790.
11陈艳华, 侯熙彦, 支德福, 李 常, 田 甜, 孙竞阳, 赵龙铉, 赵春晖; 齐墩果酸和熊果酸衍生物的合成、表征及抗癌活性的研究, 有机化学, 2016, 36(4), 795-802
12C H Zhao, C L Zhang, J J Shi, X Y Hou, B Feng, L X Zhao; Design, synthesis, and biofunctional evaluation of novel pentacyclic triterpenes bearing O-[4-(1-piperazinyl)-4-oxo-butyryl moiety as antiproliferative agents, Bioorganic & Medicinal Chemistry Letters, 2015, 25(20), 4500-4504
13付晓磊, 赵春晖, 张翼轩, 陈艳华, 李常, 赵龙铉; 对苯二酚的氨基酸缀合物的合成、表征及美白活性; 应用化学, 2015, 35(2), 158-165
14张翼轩, 张昌浩, 赵春晖, 付晓磊, 陈艳华, 李常, 李镐, 赵龙铉; 红景天苷的全合成; 合成化学; 2014, 22(6), 813-816
15C H Zhao, J Xu, Y Q Zhang, L X Zhao, B Feng; Inhibition of Human Enterovirus 71 Replication by Pentacyclic Triterpenes and Their Novel Synthetic Derivatives; Chemical & Pharmaceutical Bulletin, 2014, 62(8) 764–771
16L Wang, J Xu, C H Zhao, L X Zhao, B Feng; Antiproliferative, Cell-Cycle Dysregulation Effects of Novel Asiatic Acid Derivatives on Human Non-small Cell Lung Cancer Cell; Chemical & Pharmaceutical Bulletin, 2013, 61(10) 1015–1023
17W J Choi, H J Chung, G Chandra, V Alexander, L X Zhao, H W Lee, A Nayak, M S. Majik, H O Kim, J H Kim, Y B Lee, C H Ahn, S K Lee, L S Jeong; Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity; Journal of Medicinal Chemistry, 2012, 55(9), 4521?4525
18K M Lee, W J Choi, Y Lee, H J Lee, L X Zhao, H W Lee, J G Park, H O Kim, K Y Hwang, Y S Heo, S Choi, L S Jeong; X-ray Crystal Structure and Binding Mode Analysis of Human S-Adenosylhomocysteine Hydrolase Complexed with Novel Mechanism-Based Inhibitors, Haloneplanocin A Analogues; Journal of Medicinal Chemistry, 2011, 54(4), 930–938
19赵龙铉, 田明珠, 金礼吉, 贺兴隆, 沈平, 张晓翠, 杨君微; 积雪草酸衍生物的合成与表征及体外抗癌活性的研究; 有机化学, 2011, 31(5), 646-652
20X Pei, W J Choi, Y M Kim, L X Zhao, L SJeong; Synthesis of 3′-C-Hydroxymethyl-substituted Pyrimidine and Purine Nucleosides as Potential Anti-Hepatitis C Virus (HCV) Agents, Archives of Pharmacal Research, 2009, 31(7), 843-849,
21J K Son, L X Zhao, A Basnet, E S Lee; Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities, European Journal of Medicinal Chemistry, 2008, 43(4), 675-682,
22L S Jeong, D K Tosh, H O Kim, T Wang, X Hou, H S Yun, Y Kwon, S K Lee, J Choi, L X Zhao; First Synthesis of 4′-Selenonucleosides Showing Unusual Southern Conformation, Organic Letters, 2008, 10(2),209-212
23X Hou, H W Lee, D K Tosh, L X Zhao, L X Jeong; Alternative and Improved Syntheses of Highly Potent and Selective A3 Adenosine Receptor Agonists, Cl-IB-MECA and Thio-Cl-IB-MECA, Archives of Pharmacal Research, 2007, 30(10), 1205-1209
24C X Wei, F N Li, L X Zhao, Z S Quan; Synthesis of 2-Substituted-7-heptyloxy-4,5-dihydro-[1,2,4]-triazolo[4,3-a]quinolin-1(2H)-ones with Anticonvulsant Activity, Arch. Pharm. Chem. Life Sci., 2007, 340(9), 491-495
25T Wang, H J Lee, D K Tosh, H O Kim, S Pal, S Choi, Y Lee, H R Moon, L X Zhao, K M Lee, L S Jeong; Design, synthesis, and molecular modeling studies of 5′-deoxy-5′-ureidoadenosine: 5′-ureido group as multiple hydrogen bonding donor in the active site of S-adenosylhomocysteine hydrolase, Bioorganic & Medicinal Chemistry Letters, 2007, 17(16)，4456-4459
26L X Zhao, H G Park, S Jew, M K Lee, E S Lee; Modification of C11, C28, C2,3,23 or C2,23,28 Functional Groups on Asiatic Acid and Evaluation of Hepatoprotective Effects, Bulletin of the Korean Chemical Society, 2007, 28(6), 970-976
27L S Jeong, L X Zhao, W J Choi, S Pal, Y H Park, S K Lee, M W Chun, Y B Lee, C H Ahn, H R Moon; Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines, Nucleosides Nucleotides Nucleic Acids, 2007, 26(6), 713-716
28L X Zhao, J Sherchan, J K Park, Y Jahng, E S Lee; Synthesis, Cytotoxicity and Structure-Activity Relationship Study of Terpyridines, Archives of Pharmacal Research, 2006, 29(12), 1091-1095
29L X Zhao, M K Yun, H O Kim, J A Lee, W J Choi, K M Lee, S K Lee, Y B Lee, C H Ahn, L S Jeong, Design, Synthesis, and Anticancer Activity of Fluorocyclopentenyl-pyrimidines, Nucleic Acids Symposium Series, 2005, 49, 107-108
30L X Zhao, J G Park, Y S Moon, A Basnet, E S Lee; Design，Synthesis and Anticonvulsive Activity of Analogs of γ–Vinyl GABA, IL FARMACO, 2004, 59(5), 381-388
31Y D Jahng, L X Zhao, Y S Moon, A Basnet, E S Lee; Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities, Bioorganic & Medicinal Chemistry Letters, 2004, 14(10), 2559-2562
32L X Zhao, Y S Moon, A Basnet, E K Kim, E S Lee; Synthesis, Topoisomerase I inhibition and Structure-activity Relationship Study of 2,4,6-Trisubstituted Pyridine Derivatives, Bioorganic & Medicinal Chemistry Letters, 2004, 14(5), 1333-1337
33M S Dong, S H .Jung, H J Kim, J R Kim, L X Zhao, E S Lee; Structure-Related Cytotoxicity and Anti-Hepatofibric Effect of Asiatic Acid Derivatives in Rat hepatic Stellate Cell-Line, HSC-T6, Archives of Pharmacal Research, 2004, 27(5), 512-517,
34L X Zhao, Y S Moon, A Basnet, E S Lee; Design, Synthesis and Anticonvulsive Activities of Potential Prodrugs Linked by Two-carbon Chain, Archives of Pharmacal Research, 2003, 26(10), 785-795
35L X Zhao, E K Kim, H T Lim, Y S Moon, E S Lee; Synthesis, Characterization and In Vitro Identification of N7-Guanine Adduct of 2-Bromopropane, Archives of Pharmacal Research, 2002, 25(1), 39-44,
36L X Zhao, T S Kim, S H Ahn, T H Kim, E K Kim, E S Lee; Synthesis, Topoisomerase I Inhibition and Antitumor Cytotoxicity of Terpyridine Derivatives, Bioorganic & Medicinal Chemistry Letters, 2001, 11, 2659-2662
37Y C Kim, L X Zhao, T H Kim, S M Je, E S Lee; Design and Synthesis of Anticonvulsive Agents as g -Vinyl GABA-Based Potential Dual Acting Prodrugs and their Biological Activities, Bioorganic & Medicinal Chemistry Letters, 2000, 10, 609-613,
38S S Jew, E K Kim, S M Je, L X Zhao, E S Lee; Design and Synthesis of 2-Oxiranecarboxylate Derivatives and their Hypoglycemic Activities, Heterocycles, 2000, 52(3), 1087
专利
1T H Park, L X Zhao, S H Lee, Process for Preparation of 2-Aminopyridine Derivatives,
United States Patent Application Publication, US 2006/** A1, 2006, Mar. 2