重复6 h时差处理对小鼠行为节律影响

删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

本站小编 Free考研考试/2024-01-16

-->

李琼,马常啸,陈丽红,杨光锐.重复6 h时差处理对小鼠行为节律影响[J].,2022,62(5):454-459

重复6 h时差处理对小鼠行为节律影响

Influence of repetitive 6 h phase shifts treatment on circadian behavior of mice

DOI：10.7511/dllgxb202205002

中文关键词:时差适应性小鼠行为节律

英文关键词:phase shift adaptation mice circadian behavior

基金项目:国家自然科学基金资助项目(31871190)；辽宁省自然科学基金资助项目(2019-MS-050).

作者	单位
李琼,马常啸,陈丽红,杨光锐

摘要点击次数:253

全文下载次数:369

中文摘要:

机体受到昼夜紊乱干扰时，通常需要若干天来重新同步体内时钟与外部时钟．为研究短期多次时差处理对小鼠行为节律的影响，给予C57BL/6小鼠多次向前6 h时差(+6，即相当于向东跨越6个时区)或向后6 h时差(-6，即相当于向西跨越6个时区)，利用跑轮活动来了解小鼠适应能力的动态变化．结果显示，随着+6或-6时差次数的增加，行为适应所需时间均逐渐减少［+6时差：从(5.33±0.21)d到(1.29±0.18)d，p<0.001；-6时差：从(5.83±0.40)d到(3.00±0.37)d，p<0.001］．然而，在多次+6时差后，给予-6时差处理，小鼠的适应能力并未进一步提高［(5.71±0.61)d vs.(5.33±.21)d，p=0.95］．而先经历多次-6时差，后经历+6时差的小鼠，适应第一次+6时差所需时间显著延长［(13.14±0.55)d vs. (5.83±0.40)d，p<0.001］．这些结果表明，短期多次同向时差处理可以提高小鼠的适应性，但给予反向时差处理时适应能力并未增强，甚至有可能被显著削弱．

英文摘要:

When body is disturbed by abnormal light/dark schedules, it usually takes several days to resynchronize the internal clock with the external clock. To investigate the effect of repetitive phase shifts in a short period on circadian behavior of mice, C57BL/6 mice are treated with repetitive 6 h advance phase shift (+6, equivalent to crossing 6 time zones to eastward) and delay phase shift (-6, equivalent to crossing 6 time zones westward), and monitored by wheel running activity continuously for evaluation of behavioral adaptation.The results show that the number of days for re-entrainment decreases gradually irrespective of the phase shift direction (+6 phase shifts: from (5.33±0.21)d to (1.29±0.18)d, p<0.001; -6 phase shifts: from (5.83±0.40)d to (3.00±0.37)d,p<0.001). However, -6 phase shifts after the treatment of multiple +6 phase shifts do not further improve the adaptive ability ((5.71±0.61)d vs. (5.33±0.21)d,p=0.95). +6 phase shifts following multiple -6 phase shifts even retard behavioral adaptation ((13.14±0.55)d vs. (5.83±0.40)d,p<0.001). These results implicate that adaptation to multiple advance or delay phase shifts within a short period is gradually enhanced in mice, while the adaptation is not enhanced or even decreased when challenged by bidirectional phase shifts.

查看全文查看/发表评论下载PDF阅读器

关闭

重复6 h时差处理对小鼠行为节律影响

本站小编 Free考研考试/2024-01-16

相关话题/

领限时大额优惠券,享本站正版考研考试资料!