基于计算流体力学的血液和血栓通过静脉瓣时流动分析

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姚文瑛,许松林,吴云,汤鑫.基于计算流体力学的血液和血栓通过静脉瓣时流动分析[J].,2020,60(4):339-348

基于计算流体力学的血液和血栓通过静脉瓣时流动分析

Analysis of blood and thrombus flow through venous valve based on computational fluid dynamics

DOI：10.7511/dllgxb202004002

中文关键词:静脉瓣血液血栓计算流体力学壁面剪切力

英文关键词:venous valve blood thrombus computational fluid dynamics (CFD)wall shear stress

基金项目:国家重点研发计划资助项目(2016YFF0203802).

作者	单位
姚文瑛,许松林,吴云,汤鑫

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中文摘要:

静脉瓣存在于静脉血管中，其主要功能是防止血液逆流．结合血栓形成的要素，预测静脉中易于形成血栓的位置，并且研究血栓对静脉瓣的影响．利用计算流体力学(CFD)Fluent 19.0软件，建立静脉血管模型，在静脉瓣不同张开程度、血液不同来流速度和血液不同黏度下进行研究．得出静脉瓣窦区域中的血流会生成漩涡，并且窦区域为血流低速区和低剪切力区，静脉瓣张开程度增加、血液来流速度下降和血液黏度增加都会使静脉中低速区的血流速度更缓慢．血栓通过静脉瓣时，静脉瓣张开程度减小、血液来流速度增加以及血液黏度增加，都会使得血栓对瓣膜的剪切力增大．结果表明，在血液低流速、高黏度的状态下，窦区域的血流环境可能会导致血栓的形成．血栓会对静脉瓣造成一定的损伤，并且损伤程度随着静脉瓣张开程度的减小、血液来流速度的增加和血液黏度的增加而增加．

英文摘要:

The venous valve is in the vein. The primary function of venous valve is preventing retrograde flow of blood. The location of thrombosis in the vein is predicted in combination with the forming elements for thrombosis, and the effect of thrombus on the venous valve is investigated. Computational fluid dynamics (CFD) Fluent 19. 0 software is used and the model of vein is built. The effects of the size of leaflets opening, the blood inlet velocity and the blood viscosity are investigated. The study finds that eddies appear in the sinus region and the sinus region is low velocity and low shear stress zone. Blood flow becomes slower in the sinus region with larger size of leaflets opening, lower inlet velocity and higher viscosity of blood. The shear stress caused by the thrombus on the valve increases with smaller size of leaflets opening, higher inlet velocity and higher viscosity of blood. The results show that thrombosis is likely to occur in the sinus region under situation of low velocity and high viscosity of blood. The thrombus can cause certain damage to the venous valve. The degree of injury increases in the case of smaller size of leaflets opening, higher inlet velocity and higher viscosity of blood.

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基于计算流体力学的血液和血栓通过静脉瓣时流动分析

本站小编 Free考研考试/2024-01-16

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