基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
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个人简介Personal Profile
周宇涵，教授，2003年毕业于大连理工大学应用化学专业，获博士学位，2009年在法国巴黎第五大学药学院从事博士后研究。主要从事有机合成方法学和药物及其中间体合成工艺研究。担任学术期刊《Current Organic Chemistry》（IF 2.193）、《Modern Chemistry》、《有机化学研究》、《药物资讯》编委，学术期刊《Chemical Science》、《ChemistrySelect》、《RSC Advances》、《Journal of Heterocyclic Chemistry》、《Synlett》、《Journal of Fluorine Chemistry》、《Journal of Chromatography A》、《Molecular Crystals and Liquid Crystals》等审稿人。近年负责国家自然科学基金4项，省部级项目3项，国际及企业横向合作项目多项。在Nature Chem., Angew. Chem., J. Am. Chem. Soc, Org. Lett., Org. Chem. Front., J. Org. Chem., Dalton Trans.等杂志上发表文章60余篇，IF > 10 的3篇，参与编写中英文专著（专章）各两部（章），获发明专利授权二十余项。教育经历Education Background
工作经历Work Experience
1990.91993.7
四川省涪陵第五中学
无
2000.32003.3
大连理工大学
应用化学
博士
1997.92000.3
大连理工大学
应用化学
硕士
1993.91997.7
大连理工大学
精细化工
学士
2010.3至今
大连理工大学制药科学与技术学院
2003.32010.2
大连理工大学化工学院精细化工系
研究方向Research Focus
社会兼职Social Affiliations
药物合成
有机合成新方法研究
不对称催化
金属有机化学
基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
联系方式：**
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当前位置: 中文主页 >> 科学研究
研究领域
有机合成新方法研究
药物合成
不对称催化
金属有机化学
发表论文与专著
近年来，代表性论文如下：
[1] Yang Liu, Yuhan Zhou,* Dong Li, Han Chen, Jinfeng Zhao, Jingping Qu. Iron-catalyzed boration of cinnamyl carbonates: a highly stereoselective approach to cyclopropylboronates. Org. Chem. Front. 2019, 6, 983-988.
[2] Han Chen, Sijia Sun, Haoying Xi, Kaifang Hu, Ning Zhang, Jingping Qu, Yuhan Zhou.* Catalytic oxidative conversion of aldehydes into nitriles using NH3?H2O/FeCl2/NaI/Na2S2O8: a practical approach to febuxostat. Tetrahedron Lett. 2019, 60, 1434-1436.
[3] Yuhan Zhou, Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao, Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222.
[4] Dong Li, Yuhan Zhou*, Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Synthesis of2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J. Fluorine Chem. 2018, 212, 122-129.
[5] Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent azidation of trifluoromethyl alkenyl triflates: transition-metal-free access to CF3-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5), 2858-2868.
[6] Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang, Jingping Qu. Iron-catalyzed boration of allylic alcohols with H3BO3 as an additive. Synth. Commun. 2018, 48(7), 795-801.
[7] Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of gem-difluoroallylboronates via FeCl2-catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949.
[8] Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585.
[9] Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org. Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles).
[10] Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14.
[11] Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of 6-trichloromethylphenanthridines by transition metal-free radical cyclization of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208.
[12] Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org. Chem. 2016, 81(11), 4797-4806.
[13] Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping Qu*. Highly selective fluorescence sensors for the fluoride anion based on carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back cover)
[14] Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols. ARKIVOC 2016, (iii), 110-124.
[15] Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl2-catalyzed hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713.
[16] Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44, 14952-14958.
[17] Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe3+ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67.
[18] Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones. J. Fluorine Chem. 2015, 173, 6-11.
[19] Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109.
[20] Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77.
[21] Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674.
[22] Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520.
[23] 杨冬梅，周宇涵，* 常晴，赵一龙，曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986.
[24] Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259.
[25] Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of trifluoromethyl ketones via tandem claisen condensation and retro-claisen C?C bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)
[26] Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(μ-SeMe)3FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182.
[27] Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912.
[28] Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic. Nature Chem. 2013, 5(4), 320-326.
[29] Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087.
[30] Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction by LiCl-assisted BINOL―titanium species，Org. Lett. 2012, 14, 2734-2737.
[31] 董晓亮，周宇涵*，徐珊珊，曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026.
[32] 赵金凤，窦海建，周宇涵，曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报，2011, 32 (10), 2331-2334.
[33] Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704).
[34] Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem. Res.2010, 34(12), 684-688.
[35] Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 （Synfacts 2010, 6, 1266）.
[36] Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316.
[37] Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly efficient and regioselective allylic amination of allylic alcohols catalyzed by [Mo3PdS4] cluster. Tetrahedron Lett. 2010, 51, 1982-1984.
[38] Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.* Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010).
[39] Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663.
[40] Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Room temperature Lewis base-catalyzed alumination of terminal alkynes. Adv. Synth. Catal. 2009, 351(16): 2595-2598.
[41] Yanhui Chen, Yuhan Zhou, Pingping Chen, Yinsong Tao, Yang Li, Jingping Qu. Nitrogenase model complexes [Cp*Fe(μ-SR1)2(μ-η2-R2N=NH)FeCp*] (R1 = Me, Et; R2 = Me, Ph; Cp* = η5-C5Me5): synthesis, structure, and catalytic N-N bond cleavage of hydrazines on diiron centers. J. Am. Chem. Soc. 2008, 130(46): 15250-15251 (JACS β Select issue 9).
[42] Yuhan Zhou, Guchao Gao, Hui Li, Jingping Qu. A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2SO4/B(OMe)3, Tetrahedron Lett. 2008, 49, 3260-3263.
[43] Yanhui Chen, Yuhan Zhou, Jingping Qu. Synthesis and reactions of novel triply thiolate-bridged diiron complexes [Cp*Fe(μ2-SR)3FeCp*] (Cp*= η5-C5Me5; R = Et, Ph), Organometallics 2008, 27(4), 666–671.
专著
[1] Yuhan Zhou*, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12).
[2] Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Ko?mrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232.
[3] 李和平，周宇涵，冯光柱，申艳敏，黄雪，刘云，袁超，何利霞. 含氟溴碘精细化学品. 北京：化学工业出版社，2010-09-01.（“十一五国家重点图书”）
[4] 李和平，冯光柱，魏文珑，孙建军，周宇涵，黄雪. 含氯精细化学品. 北京：化学工业出版社，2010-08-01. （“十一五国家重点图书”）
授权专利
授权专利：
[1] 周宇涵，苗蔚荣. 取代苯基吡唑类除草剂. CN **A，2003-3-19, 专利号：ZL**.1, 2005-12-28.
[2] 周宇涵，苗蔚荣. 四取代苯基噁唑烷酮类除草剂. CN **A，2001-1-24, 专利号：ZL**.7, 2003-7-9.
[3] 周宇涵，苗蔚荣. 取代苯基异噁唑类除草剂. CN**, 2007-4-4, 专利号：ZL**7.3, 2008-8-13.
[4] 周宇涵，曲景平，薛娜，王国伟. 一种除草剂及其制备方法. 专利号：**8.1，2012-2-29. CN**, 2008-9-24.
[5] 周宇涵，曲景平，薛娜，王国伟. 苯并噁唑类除草剂及其制备方法. 专利号：**7.x，2011-2-2. CN**, 2008-10-8.
[6] 曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和二氮烯架桥的双核铁配合物、其制备方法及应用. 专利号：**2.6, 2014.6.25. CN **, 2012-7-11.
[7] 曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和氨/胺架桥的双核铁配合物、其制备方法及应用. 专利号：**1.1, 2014.8.27. CN **, 2012-7-25.
[8] 曲景平，赵金凤，周宇涵，李阳，贾春媚，王磊，陈延辉. 烃硫基和氮/氨基架桥的双核铁配合物、其制备方法及应用. 专利号：**1.6, 2014-8-27. CN **A, 2012.8.1.
[9] 周宇涵，曲景平，杨冬梅，薛娜. 一种制备全氟烷基烷基酮化合物的方法. 专利号：**0.2，2015-2-25. CN **A, 2013.2.13.
[10] 宋伟国，周宇涵，付永强，董良军，徐文方. 一种拉唑类化合物单一对映体的分离方法. 专利号：**9.0，2015-6-17. CN **A, 2013-07-10.
[11] 宋伟国，付永强，孙晓明，董良军，高东圣，周宇涵，夏艳，王伟，吕伟香，田梅. 一种用于埃索美拉唑不对称合成的催化剂. 专利号: **7.5, 2016.7.6. CN**A, 2014.09.10.
[12] 周宇涵，曲景平，董晓亮. 一类以蒽为母体的双功能荧光探针、制备方法及应用. 专利号: **9.X, 2016.12.7. CN**A, 2015.7.22.
[13] 周宇涵，曲景平，柳阳，王欢.基于铁催化制备烷基硼酸酯化合物的方法.专利号:**1.5, 2017.6.27，申请日：2015.6.1. CN**A, 2015.9.9.
[14] 周宇涵，曲景平，董晓亮. 一类羧酸根桥联双核铁配合物荧光探针、制备方法及应用. 专利号: **9.9, 2017.10.24. CN**A, 2015.11.25.
[15] 董良军，周宇涵，高东圣，王福洲，褚亚飞，吕伟香，李书涛，杨磊，宋伟国. 一种适用于工业化生产的右兰索拉唑的处理方法. 专利号：**4.5，2017.11.28，申请日期：2015.12.20.
[16] 周宇涵，曲景平，柳阳，赵一龙. 一种二氟烯丙基硼酸酯的制备方法及其应用. 专利号: **2.0, 2018.3.13，申请日期：2016.8.4.
[17] 周宇涵，曲景平，吴昌朋，董晓亮. 一类6-三氯甲基菲啶类化合物及其制备方法和应用. 专利号：ZL **7.0，2018.7.13，申请日期：2016.5.5. CN**B, 2016.8.17.
[18] 褚亚飞，周宇涵，杨磊，高东圣，董良军，王福洲，王洪明，侯俊杰，宋伟国. 一种埃索美拉唑及其盐的制备方法. 专利号：ZL**8.0, 2018.06.01. CN**A, 2016.6.15.
[19] Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. JP 2017-558380, 2018.12.14.
[20] Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. US **B2, 申请日：2017.1.19；授权：2019.7.16.
[21] 周宇涵，曲景平，赵一龙，张成海，奚灏瀛，董述祥，范文霞. 一种1-芳基-3-叠氮基-4，4，4-三氟-1-丁烯化合物的制备方法. ZL**4.1, CN**B, 2019.8.20, 申请日期：2017.6.30.
[22] Yuhan Zhou, Jingping Qu, Yang Liu, Yilong Zhao. Method for preparing difluoroallylboronate and applicationthereof. US **B2, 申请日：2017.6.23；授权：2019.12.3.
科研项目 More>>
多酚及环氧化合物合成, 企事业单位委托科技项目, 2014/11/15-2020/12/31, 进行
双/多酚类化合物合成, 国际合作项目, 2014/11/15, 完成
铁催化烯烃的硼化反应及其机理研究, 国家自然科学基金项目, 2015/08/18, 进行
氯氮平合成工艺, 企事业单位委托科技项目, 2014/12/31-2016/12/31, 完成
（R)-兰索拉唑合成技术, 企事业单位委托科技项目, 2012/08/08-2016/08/31, 完成
金属络合物催化的高选择性三氟乙酸酯酮交换反应研究, 国家自然科学基金项目, 2013/09/25-2017/12/31, 完成
空 More>>
Zhou, Yuhan,Zhang, Chunxia,Zhao, Yilong,Li, Dong,Zhao, Jinfeng,Wang, Zhaotian,Qu, Jingping.Base-Promoted Double-Bond-Migration/Hydrolysis/Isomerization of 4-Aryl-1,1,1-trifluorobut-2-en-2-yl Trifluoromethanesulfonates: A Metal-Free Approach to beta-Trifluoromethyl Ketones[J],EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2018,2018(45):6217-6222
Li, Dong,Zhou, Yuhan,Zhao, Yilong,Zhang, Chunxia,Li, Jianzhe,Zhao, Jinfeng,Qu, Jingping.Synthesis of 2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes[J],JOURNAL OF FLUORINE CHEMISTRY,2018,212:122-129
Zhao Yilong,Zhou Yuhan,Zhang Chunxia,Li Dong,Sun Puhua,Li Jianzhe,Wang Huan,Liu Jianhui,Qu Jingping.Base-Controlled Regiodivergent Azidation of Trifluoromethyl Alkenyl Triflates: Transition-Metal-Free Access to CF3-Containing Allyl Azides and Alkenyl Azides.[J],The Journal of organic chemistry,2018,83(5):2858-2868
Zhou, Yuhan,Wang, Huan,Liu, Yang,Zhao, Yilong,Zhang, Chunxia,Qu, Jingping.Iron-catalyzed boration of allylic alcohols with H3BO3 as an additive[J],SYNTHETIC COMMUNICATIONS,2018,48(7):795-801
周宇涵,赵金凤,曲景平.Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones.[J],Eur. J. Org. Chem.,2018,2018:6217-6222
Zhou, Yuhan,Wang, Huan,Liu, Yang,Zhao, Yilong,Zhang, Chunxia,Qu, Jingping.Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates[J],ORGANIC CHEMISTRY FRONTIERS,2017,4(8):1580-1585
基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
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研究领域
当前位置: 中文主页 >> 科学研究 >> 研究领域有机合成新方法研究
药物合成
不对称催化
金属有机化学
基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
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发表论文与专著
当前位置: 中文主页 >> 科学研究 >> 发表论文与专著近年来，代表性论文如下：
[1] Yang Liu, Yuhan Zhou,* Dong Li, Han Chen, Jinfeng Zhao, Jingping Qu. Iron-catalyzed boration of cinnamyl carbonates: a highly stereoselective approach to cyclopropylboronates. Org. Chem. Front. 2019, 6, 983-988.
[2] Han Chen, Sijia Sun, Haoying Xi, Kaifang Hu, Ning Zhang, Jingping Qu, Yuhan Zhou.* Catalytic oxidative conversion of aldehydes into nitriles using NH3?H2O/FeCl2/NaI/Na2S2O8: a practical approach to febuxostat. Tetrahedron Lett. 2019, 60, 1434-1436.
[3] Yuhan Zhou, Chunxia Zhang, Yilong Zhao, Dong Li, Jinfeng Zhao, Zhaotian Wang, Jingping Qu. Base-promoted double-bond-migration/hydrolysis/isomerization of 4-aryl-1,1,1-trifluorobut-2-en-2-yl trifluoromethanesulfonates: a metal-free approach to β-trifluoromethyl ketones. Eur. J. Org. Chem. 2018, 6217-6222.
[4] Dong Li, Yuhan Zhou*, Yilong Zhao, Chunxia Zhang, Jianzhe Li, Jinfeng Zhao, Jingping Qu. Synthesis of2-trifluoromethyl-2-hydroxy-2H-chromenes via cyclization of (Z)-trifluoromethyl alkenyl triflates and salicylaldehydes. J. Fluorine Chem. 2018, 212, 122-129.
[5] Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Dong Li, Puhua Sun, Jianzhe Li, Huan Wang, Jianhui Liu, Jingping Qu. Base-controlled regiodivergent azidation of trifluoromethyl alkenyl triflates: transition-metal-free access to CF3-containing allyl azides and alkenyl azides. J. Org. Chem. 2018, 83(5), 2858-2868.
[6] Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang, Jingping Qu. Iron-catalyzed boration of allylic alcohols with H3BO3 as an additive. Synth. Commun. 2018, 48(7), 795-801.
[7] Yang Liu, Yuhan Zhou,* Yilong Zhao, Jingping Qu. Synthesis of gem-difluoroallylboronates via FeCl2-catalyzed boration/β-fluorine elimination of trifluoromethyl alkenes. Org. Lett. 2017, 19(4), 946-949.
[8] Yuhan Zhou,* Huan Wang, Yang Liu, Yilong Zhao, Chunxia Zhang and Jingping Qu. Iron-catalyzed boration of allylic esters: an efficient approach to allylic boronates. Org. Chem. Front. 2017, 4(8), 1580 - 1585.
[9] Yilong Zhao, Yuhan Zhou,* Chunxia Zhang, Huan Wang, Jinfeng Zhao, Kun Jin, Jihong Liu, Jianhui Liu, Jingping Qu. Palladium-catalyzed geometrically selective hydrogenation of (Z)-trifluoromethyl alkenyl triflate: an efficient approach to (Z) or (E)-3,3,3-trifluoropropenyl derivatives. Org. Biomol. Chem. 2017, 15(27), 5693-5700. (Inside front cover, 2017 Hot Articles).
[10] Yuhan Zhou,* Ling Li, Xiaoliang Dong, Yixin Zhang, Dawei Yang, Yang Liu, Jingping Qu.* Synthesis of diiron sulfur clusters containing thiolato-1,8-naphthalene imide ligand. Inorg. Chem. Commun. 2017, 80, 10-14.
[11] Yuhan Zhou,* Changpeng Wu, Xiaoliang Dong, Jingping Qu. Synthesis of 6-trichloromethylphenanthridines by transition metal-free radical cyclization of 2-isocyanobiphenyls. J. Org. Chem. 2016, 81(12), 5202-5208.
[12] Yilong Zhao, Yuhan Zhou,* Juan Liu, Dongmei Yang, Liang Tao, Yang Liu, Xiaoliang Dong, Jianhui Liu, Jingping Qu. Synthesis of (Z)-α-trifluoromethyl alkenyl triflate: a scaffold for diverse trifluoromethylated species. J. Org. Chem. 2016, 81(11), 4797-4806.
[13] Yuhan Zhou,* Xiaoliang Dong, Yixin Zhang, Peng Tong, and Jingping Qu*. Highly selective fluorescence sensors for the fluoride anion based on carboxylate-bridged diiron complexes. Dalton Trans. 2016, 45, 6839-6846. (back cover)
[14] Changpeng Wu, Yuhan Zhou,* Xiaoliang Dong, Jingping Qu. Synthesis of 6-(arylthio)phenanthridines by cyclization reaction of 2-isocyanobiphenyls with thiols. ARKIVOC 2016, (iii), 110-124.
[15] Yang Liu, Yuhan Zhou,* Huan Wang and Jingping Qu. FeCl2-catalyzed hydroboration of aryl alkenes with bis(pinacolato)diboron. RSC Adv. 2015, 5, 73705-73713.
[16] Xiaoliang Dong, Litao Liu, Yuhan Zhou,* Jun Liu, Yixin Zhang, Yanhui Chen, and Jingping Qu.* Synthesis of carboxylate-bridged iron-thiolate clusters from alcohols/aldehydes or carboxylate salts. Dalton Trans. 2015, 44, 14952-14958.
[17] Xiaoliang Dong, Yuhan Zhou,* Yuming Song, Jingping Qu. Anthracene-Fe3+ ensemble based turn-on fluorescent probes for selective detection of fluoride. J. Fluorine Chem. 2015, 178, 61-67.
[18] Dongmei Yang, Yuhan Zhou,* Yuming Song, Jingping Qu. A practical synthesis of trifluoromethyl alkyl ketones. J. Fluorine Chem. 2015, 173, 6-11.
[19] Yuhan Zhou,* Yuming Song, Yang Liu, Jingping Qu. A convenient one-pot preparation of spiro[fluorene-9,9’-xanthene]-3’,6’-diol derivatives. ARKIVOC 2015 (v), 99-109.
[20] Weiguo Song, Liangjun Dong, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Catalytic asymmetric synthesis of esomeprazole by a titanium complex with a hexaaza triphenolic macrocycle ligand. Synth. Commun., 2015, 45(1), 70-77.
[21] Yuhan Zhou,* Dongmei Yang, Gen Luo, Yilong Zhao, Yi Luo,* Na Xue, Jingping Qu. Highly selective trifluoroacetic ester/ketone metathesis: an efficient approach to trifluoromethyl ketones and esters. Tetrahedron 2014, 70(31), 4668-4674.
[22] Yuhan Zhou,* Guchao Gao, Yuming Song, Jingping Qu*. Enantioselective reduction of prochiral ketones with NaBH4/Me2SO4/(S)-Me-CBS. Synth. Commun., 2014, 44(10), 1515-1520.
[23] 杨冬梅，周宇涵，* 常晴，赵一龙，曲景平. 三氟甲基烷基酮的生物活性及合成方法. 化学进展 2014, 26(6), 976-986.
[24] Xiaoneng Cui, Jianzhang Zhao, Yuhan Zhou, Jie Ma, Yilong Zhao. Reversible photoswitching of triplet-triplet annihilation upconversion using dithienylethene photochromic switches. J. Am. Chem. Soc. 2014, 136, 9256-9259.
[25] Dongmei Yang, Yuhan Zhou,* Na Xue, Jingping Qu.* Synthesis of trifluoromethyl ketones via tandem claisen condensation and retro-claisen C?C bond-cleavage reaction. J. Org. Chem. 2013, 78(8), 4171-4176. (“organic-chemistry.org”专题报道: J42-Y2013)
[26] Jinfeng Zhao, Lei Wang, Yuhan Zhou,* Yixin Zhang, Nan Zhang, Chunmei Jia, Fengshuo Hu, Yanhui Chen, Baomin Wang, Jingping Qu.* Synthesis, structure and reactions of triply selenolate-bridged diiron complex [Cp*Fe(μ-SeMe)3FeCp*]. Inorg. Chem. Commun. 2013, 29, 179-182.
[27] Weiguo Song, Yuhan Zhou,* Yongqiang Fu, Wenfang Xu. Self-disproportionation of enantiomers of prazoles via achiral, gravity-driven silica gel column chromatography. Tetrahedron: Asymmetry 2013, 24(15-16), 909-912.
[28] Yang Li, Ying Li, Baomin Wang, Yi Luo, Dawei Yang, Peng Tong, Jinfeng Zhao, Lun Luo, Yuhan Zhou, Si Chen, Fang Cheng, Jingping Qu. Ammonia formation by a thiolate-bridged diiron amide complex as a nitrogenase mimic. Nature Chem. 2013, 5(4), 320-326.
[29] Jinfeng Zhao, Lei Wang, Yuhan Zhou, Yixin Zhang, Nan Zhang, Yanhui Chen, Jingping Qu. Synthesis and characterization of a thiolate-bridged diiron complex with two monocoordinated azido ligands: [Cp*Fe(μ-SMe)N3]2 (Cp* = η5-C5Me5). Chinese J. Struc. Chem. 2013, 32 (7), 1083-1087.
[30] Guowei Wang, Baomin Wang, Shuai Qi, Jinfeng Zhao, Yuhan Zhou, Jingping Qu*. Highly enantio- and diastereoselective vinylogous aldol reaction by LiCl-assisted BINOL―titanium species，Org. Lett. 2012, 14, 2734-2737.
[31] 董晓亮，周宇涵*，徐珊珊，曲景平*. 5-芳甲氧基苯基吡唑衍生物的合成及除草活性. 有机化学, 2011, 31(7), 1020-1026.
[32] 赵金凤，窦海建，周宇涵，曲景平. (S,S)-TsDPEN-Ru催化不对称氢转移还原β-胺基酮及在度洛西汀合成中的应用. 高等学校化学学报，2011, 32 (10), 2331-2334.
[33] Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct synthesis of 1,4-disubstituted-5-alumino-1,2,3-triazoles by a copper-catalyzed cycloaddition of organic azides and mixed-aluminum acetylides. Angew. Chem. Int. Ed. 2010, 49(14), 2607-2610 (Synfacts 2010, 6, 0704).
[34] Yuhan Zhou,* Na Xue, Guowei Wang, Jingping Qu. Synthesis, structure and herbicidal activity of substituted phenyl pyrazole derivatives. J. Chem. Res.2010, 34(12), 684-688.
[35] Guowei Wang, Jinfeng Zhao, Yuhan Zhou, Baomin Wang, Jingping Qu. Mild and highly enantioselective vinylogous aldol reaction of brassard’s diene with aromatic aldehydes by combined Lewis acid catalyst. J. Org. Chem. 2010, 75(15), 5326-5329 （Synfacts 2010, 6, 1266）.
[36] Yuhan Zhou,* Yanhui Chen, Weirong Miao, Jingping Qu. Synthesis, structures and herbicidal activity of isoxazole derivatives. J. Heterocyclic Chem. 2010, 47(6), 1310-1316.
[37] Yinsong Tao, Yuhan Zhou, Jingping Qu, Masanobu Hidai. Highly efficient and regioselective allylic amination of allylic alcohols catalyzed by [Mo3PdS4] cluster. Tetrahedron Lett. 2010, 51, 1982-1984.
[38] Na Xue, Yuhan Zhou,* Guowei Wang, Weirong Miao, Jingping Qu.* Syntheses and herbicidal activity of pyrazolyl benzoxazole derivatives. J. Heterocyclic Chem. 2010, 47(1): 15-21 (Top accessed papers from 2010).
[39] Pingping Chen, Yanhui Chen, Yuhan Zhou, Ying Peng, Jingping Qu, Masanobu Hidai. Heterometallic cubane-type clusters [MMo3S4] (M = Au, Ag and Cu): synthesis, structures and electrochemical properties. Dalton Trans. 2010, 39, 5658 – 5663.
[40] Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Room temperature Lewis base-catalyzed alumination of terminal alkynes. Adv. Synth. Catal. 2009, 351(16): 2595-2598.
[41] Yanhui Chen, Yuhan Zhou, Pingping Chen, Yinsong Tao, Yang Li, Jingping Qu. Nitrogenase model complexes [Cp*Fe(μ-SR1)2(μ-η2-R2N=NH)FeCp*] (R1 = Me, Et; R2 = Me, Ph; Cp* = η5-C5Me5): synthesis, structure, and catalytic N-N bond cleavage of hydrazines on diiron centers. J. Am. Chem. Soc. 2008, 130(46): 15250-15251 (JACS β Select issue 9).
[42] Yuhan Zhou, Guchao Gao, Hui Li, Jingping Qu. A convenient method to reduce hydroxyl-substituted aromatic carboxylic acid with NaBH4/Me2SO4/B(OMe)3, Tetrahedron Lett. 2008, 49, 3260-3263.
[43] Yanhui Chen, Yuhan Zhou, Jingping Qu. Synthesis and reactions of novel triply thiolate-bridged diiron complexes [Cp*Fe(μ2-SR)3FeCp*] (Cp*= η5-C5Me5; R = Et, Ph), Organometallics 2008, 27(4), 666–671.
专著
[1] Yuhan Zhou*, Xiaoliang Dong, Jingping Qu. Synthesis, structure and herbicidal activity of pyrazole derivatives. in Daiki Kobayashi and Eito Watanabe Edit: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications (Chapter 13) USA: Nova Science Publishers, 2013, 263-276 (2013-12).
[2] Serge Mignani, Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Recent Developments in the Synthesis 1,4,5-Trisubstituted Triazoles. Topics in Heterocyclic Chemistry Vol. 28: Click Triazoles. (Edited by Janez Ko?mrlj.) Springer-Verlag Berlin Heidelberg: 2012, 185-232.
[3] 李和平，周宇涵，冯光柱，申艳敏，黄雪，刘云，袁超，何利霞. 含氟溴碘精细化学品. 北京：化学工业出版社，2010-09-01.（“十一五国家重点图书”）
[4] 李和平，冯光柱，魏文珑，孙建军，周宇涵，黄雪. 含氯精细化学品. 北京：化学工业出版社，2010-08-01. （“十一五国家重点图书”）
基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
联系方式：**
电子邮箱：
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授权专利
当前位置: 中文主页 >> 科学研究 >> 授权专利授权专利：
[1] 周宇涵，苗蔚荣. 取代苯基吡唑类除草剂. CN **A，2003-3-19, 专利号：ZL**.1, 2005-12-28.
[2] 周宇涵，苗蔚荣. 四取代苯基噁唑烷酮类除草剂. CN **A，2001-1-24, 专利号：ZL**.7, 2003-7-9.
[3] 周宇涵，苗蔚荣. 取代苯基异噁唑类除草剂. CN**, 2007-4-4, 专利号：ZL**7.3, 2008-8-13.
[4] 周宇涵，曲景平，薛娜，王国伟. 一种除草剂及其制备方法. 专利号：**8.1，2012-2-29. CN**, 2008-9-24.
[5] 周宇涵，曲景平，薛娜，王国伟. 苯并噁唑类除草剂及其制备方法. 专利号：**7.x，2011-2-2. CN**, 2008-10-8.
[6] 曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和二氮烯架桥的双核铁配合物、其制备方法及应用. 专利号：**2.6, 2014.6.25. CN **, 2012-7-11.
[7] 曲景平，李阳，周宇涵，杨大伟，李莹，童鹏，赵金凤. 邻苯二硫酚基和氨/胺架桥的双核铁配合物、其制备方法及应用. 专利号：**1.1, 2014.8.27. CN **, 2012-7-25.
[8] 曲景平，赵金凤，周宇涵，李阳，贾春媚，王磊，陈延辉. 烃硫基和氮/氨基架桥的双核铁配合物、其制备方法及应用. 专利号：**1.6, 2014-8-27. CN **A, 2012.8.1.
[9] 周宇涵，曲景平，杨冬梅，薛娜. 一种制备全氟烷基烷基酮化合物的方法. 专利号：**0.2，2015-2-25. CN **A, 2013.2.13.
[10] 宋伟国，周宇涵，付永强，董良军，徐文方. 一种拉唑类化合物单一对映体的分离方法. 专利号：**9.0，2015-6-17. CN **A, 2013-07-10.
[11] 宋伟国，付永强，孙晓明，董良军，高东圣，周宇涵，夏艳，王伟，吕伟香，田梅. 一种用于埃索美拉唑不对称合成的催化剂. 专利号: **7.5, 2016.7.6. CN**A, 2014.09.10.
[12] 周宇涵，曲景平，董晓亮. 一类以蒽为母体的双功能荧光探针、制备方法及应用. 专利号: **9.X, 2016.12.7. CN**A, 2015.7.22.
[13] 周宇涵，曲景平，柳阳，王欢.基于铁催化制备烷基硼酸酯化合物的方法.专利号:**1.5, 2017.6.27，申请日：2015.6.1. CN**A, 2015.9.9.
[14] 周宇涵，曲景平，董晓亮. 一类羧酸根桥联双核铁配合物荧光探针、制备方法及应用. 专利号: **9.9, 2017.10.24. CN**A, 2015.11.25.
[15] 董良军，周宇涵，高东圣，王福洲，褚亚飞，吕伟香，李书涛，杨磊，宋伟国. 一种适用于工业化生产的右兰索拉唑的处理方法. 专利号：**4.5，2017.11.28，申请日期：2015.12.20.
[16] 周宇涵，曲景平，柳阳，赵一龙. 一种二氟烯丙基硼酸酯的制备方法及其应用. 专利号: **2.0, 2018.3.13，申请日期：2016.8.4.
[17] 周宇涵，曲景平，吴昌朋，董晓亮. 一类6-三氯甲基菲啶类化合物及其制备方法和应用. 专利号：ZL **7.0，2018.7.13，申请日期：2016.5.5. CN**B, 2016.8.17.
[18] 褚亚飞，周宇涵，杨磊，高东圣，董良军，王福洲，王洪明，侯俊杰，宋伟国. 一种埃索美拉唑及其盐的制备方法. 专利号：ZL**8.0, 2018.06.01. CN**A, 2016.6.15.
[19] Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. JP 2017-558380, 2018.12.14.
[20] Yuhan Zhou, Jingping Qu, Xiaoliang Dong. Carboxylate-bridged binuclear iron-sulfur clusters fluorescent probe preparation method and application thereof. US **B2, 申请日：2017.1.19；授权：2019.7.16.
[21] 周宇涵，曲景平，赵一龙，张成海，奚灏瀛，董述祥，范文霞. 一种1-芳基-3-叠氮基-4，4，4-三氟-1-丁烯化合物的制备方法. ZL**4.1, CN**B, 2019.8.20, 申请日期：2017.6.30.
[22] Yuhan Zhou, Jingping Qu, Yang Liu, Yilong Zhao. Method for preparing difluoroallylboronate and applicationthereof. US **B2, 申请日：2017.6.23；授权：2019.12.3.
基本信息Personal Information
教授博士生导师
硕士生导师
主要任职：无
其他任职：药学系副主任
性别：男
毕业院校：大连理工大学
学位：博士
在职信息：在职
所在单位：化工学院
学科：药物工程 药物化学 精细化工
办公地点：大连理工大学西校区化工实验楼G411
联系方式：**
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科研项目
当前位置: 中文主页 >> 科学研究 >> 科研项目多酚及环氧化合物合成, 2014/11/15-2020/12/31, 进行
双/多酚类化合物合成, 一般纵向, 2014/11/15, 完成
铁催化烯烃的硼化反应及其机理研究, 国家自然科学基金, 2015/08/18, 进行
氯氮平合成工艺, 2014/12/31-2016/12/31, 完成
（R)-兰索拉唑合成技术, 2012/08/08-2016/08/31, 完成
金属络合物催化的高选择性三氟乙酸酯酮交换反应研究, 国家自然科学基金, 2013/09/25-2017/12/31, 完成
杂环Protox抑制剂的结构设计、合成与生物活性研究, 国家自然科学基金, 2006/09/25-2009/12/31, 完成
功能精细化学品设计与合成, 2018/03/22-2020/03/31, 进行
三氟甲基烯基酯不对称转化及其机理研究, 国家自然科学基金, 2018/08/16, 进行
非布司他合成工艺, 2017/06/15-2020/12/31, 进行
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