大连民族大学硕士专业学位研究生导师信息
姓名： 权春善
职称/职务： 教授
电话： **
E-Mail： mikyeken@dlnu.edu.cn
所在学院： 生命科学学院
更新时间： 2015.09
个人简介（含主要学习和工作经历）

1989.09-1993.04 大连轻工业学院 发酵工程 学士

1993.09-1996.04 大连轻工业学院 发酵工程 硕士

2000.04-2003.03 日本广岛大学 生物工程 博士

1996.04-1999.03 大连民族学院化学工程系 讲师

2010.09--- 大连民族大学生命科学学院 教授

2008.06-2006.11 日本筑波大学生命环境研究科 访问学者

2008.08-2008.11 日本筑波大学生命环境研究科 研究员

研究领域（含研究课题）

主要从事与生物化工和微生物工程相关的基础理论与应用研究工作。由申请人主持和负责的研究小组，

近五年的研究方向为：（1）微生物细胞信号转导的分子机制及药物筛选；（2）微生物资源筛选与代

谢产物的调控。

1.国家自然科学基金：基于化学仿生体系的细菌细胞跨膜信号转导机制研究 （**）

2.中央高校基金：以金黄色葡萄球菌群体感应受体AgrC为靶点的抗菌化合物的筛选及其抗菌机理研究

（DC**1）

3.“十二五”农村领域国家科技计划课题子课题：鲜活农产品物流过程金黄色葡萄球菌检测及其监控技

术研究（2012BAD38B05-1-1）

4.国家自然科学基金：生物体系外细菌信号转导机理的化学生物学研究（**）

5.教育部科学技术研究重点项目：AgrC跨膜镶嵌的人工细胞模型的构建及细菌信号转导机制的研究

（209153）

6.辽宁省教育厅：金黄色葡萄球菌agr系统受体蛋白AgrC的克隆表达及性质研究（2009A158）

7.辽宁省教育厅：新型水产饲用抗生素替代品开发与应用（LS**）

8.大连市科技局：构树资源的生物技术综合开发研究（2010J21DW027）

9.中央高校基金：细胞信息传递过程的化学生物学研究（DC**）

10.国家自然科学基金：生物体系外表达离子通道型细胞信号转导机能的超分子研究

出版专著

1.Plant Growth and Health Promoting Bacteria. Microbiology Monographs, Springer, Germany.

2010, p117-p156

2.胡文忠，权春善，范圣第，编著. 应用生命科学实验技术. 辽宁大学出版社，2005年，教材。

发表论文

1.Wang, L.N., Quan, C.S.*, Xiong, W., Qu, X.J., Fan, S.D, Hu, W.Z. (2014) New insight ito

transmembrane topology of Staphylococcus aureus histidine kinase AgrC. BBA-Biomembranes,

1838(3), 988-993.

2.Zhao, P.C., Quan, C.S.*, Wang, Y.G., Wang, J.H., Fan, S.D. （2014） Bacillus

amyloliquefaciens Q-426 as a potential biocontrol agent against Fusarium oxysporum f. sp.

spinaciae. J Basic Microbiol., 54(5), 448-456.

3.Zhao, P.C., Quan, C.S.*, Jin, L.M., Wang, L.N., Guo, X.J., Fan, S.D. (2013) Sequence

characterization and computational a nalysis of the non-ribosomal peptide synthetases

controlling biosynthesis of lipopeptides, fengycins and bacillomycin D from Bacillus

amyloliquefaciens Q-426. Biotechnol Lett., 35, 2155-2163.

4.Wang, L.N., Quan, C.S.*, Liu, B.Q., Wang, J.F., Xiong, W., Zhao, P.C., Fan, S.D. (2013)

Functional Reconstitution of Staphylococcus aureus Truncated AgrC Histidine Kinase into

Model Membrane System. Plos One., 8(11), e80400.

5.Wang, L.N., Quan, C.S.*, Liu, B.Q., Xu, Y.B., Zhao, P.C., Xiong, W., Fan, S.D. (2013)

Green Fluorescent Protein (GFP)-Based Overexpression Screening and Characterization of

AgrC, a Receptor Protein of Quorum Sensing in Staphylococcus aureus. Int. J. Mol. Sci.,

14, 18470-18487.

6.Zhao, P.C., Quan, C.S.*, Jin, L.M., Wang, L.N., Fan, S.D., (2013) Effects of critical

medium components on the production of antifungal lipopeptides from Bacillus

amyloliquefaciens Q-426 exhibiting excellent biosurfactant properties. World Microbiol.

Biotechnol., 29, 401-409.

7.Wang, J.H., Quan, C.S.*, Wang, X., Zhao, P.C., Fan, S.D., (2011) Extraction,purification

and identification of bacterial signal molecules based on N-acyl homoserine lactones. M

icrobial Biotechnology., 4(4), 479-490.

8.Quan, C.S.*, Ma, J.L., Wang, X., Li, W., Fan S.D. (2010) Construction of an artificial

signal transduction system on bilayer vesicles: Insertion of transmembrane peptide of

bacterial histidine protein kinase on bilayer vesical. Acta Chim Sinica., 68(12),

1167-1173.

9.Wang, J.H., Quan, C.S.*, Li, X., Qi, X.H., Fan, S.D., (2010) Determination of

diketopiperazines of Burkholderia cepacia CF-66 by gas chromatography-mass spectrometry.

Analytical and Bioanalytical Chemistry., 396, 1773-1779.

10.Quan, C.S.*, Li, X., Wang, J.H., Wang, J.H., Zheng, W., Fan, S.D., (2009) Optimal

control of a batch bioreactor for the production of a novel antifungal substance CF66I.

African Journal of Biotechnology., 8(21), 5702-5710.

11.Li, X., Quan, C.S.*, Yu, H.Y., Wang, J.H., Fan, S.D., (2009) Assessment of antifungal

effects of a novel compound from Burkholderia cepacia against Fusarium solani by

fluorescent staining. World J. Microbiol. Bioltechnol., 25, 151-154.

12.Li, X., Quan, C.S.*, Yu, H.Y., Fan, S.D., (2008) Multiple effects of a novel compound

from Burkholderia cepacia against Candida albicans. FEMS Microbiology Letters., 285(2),

250-256.

13.Li, X., Quan, C.S.*, Fan, S.D., (2007) Antifungal activity of a novel compound from

Burkholderia cepacia against plant pathogenic fungi. Letters in Applied Microbiology.,

45(5), 508-514.

14.Quan, C.S.*, Zheng, W., Liu, Q., Ohta, Y., Fan, S.D., (2006) Isolation and

characterization of a novel Burkholderia cepacia with strong antifungal activity against

Rhizoctonia solani. Applied Microbiology and Biotechnology., 72(6), 1276-1284.

15.Quan, C.S.*, Liu, Q., Tian, W.J., Kikuchi, J., Fan, S.D., (2005) Biodegradation of an

endocrine-disrupting chemical, di-2-ethylhexyl phthalate, by Bacillus subtilis No.66.

Applied Microbiology and Biotechnology., 66(6), 702-710.

16.Quan, C.S.*, Tian, W.J., Fan, S.D., Kikuchi, Y., (2004) Purification and properties

of a low-molecular-weight phytase from Cladosporium sp. FP-1., 97(4), 260-266.

17. Quan, C.S.*, Fan, S.D., Ohta, Y., (2003) Immobilization of Candida krusei cells

producing phytase in alginate gel beads: an application of the preparation of myo-inositol

phosphates. Appl. Microbiol. Biotechnol., 62, 41-47.

18. Quan, C.S.*, Fan, S.D., Ohta Y., (2003) Pathway of Dephosphorylation of myo-Inositol

hexakis- phosphate by a novel phytase from Candida krusei WZ-001. J. Biosci. Bioeng.,

95(5), 530-533.

19. Quan, C.S.*., Fan, S.D., Zhang, L.H., Wang, Y.J., Ohta, Y., (2002) Purification and

properties of a phytase from Candida krusei WZ-001. J. Biosci. Bioeng., 94, 419.

20. Quan, C.S.*, Zhang, Y., Wang, J., Ohta Y., (2001) Production of phytase in a low

phosphate medium by a novel yeast Candida krusei. J. Biosci. Bioeng., 92, 154.

21. Zhang, H., Wang, W.X., Quan, C.S.*, Fan, S.D., (2010) Engineering considerations for

process development in Mammalian cell cultivation. Current Pharmaceutical Biotechnology.,

11(1), 103-112.

22. Wang, Y.L., Chai, T.J., Lu, G.Z., Quan, C.S., Duan, H.Y., Yao, M.L., Zuckerc, B-A,

Schlenker, G., (2008) Simultaneous detection of airborne aflatoxin, ochratoxin and

zearalenone in a poultry house by immunoaffinity clean-up and high-performance liquid c

hromatography. Environmental Research., 107(2), 139-144.

获奖、鉴定、转让、专利等成果

1. Biodegradation of an endocrine-disrupting chemical, di-2-ethylhexyl phthalate, by

Bacillus subtilis No. 66. 辽宁省自然科学学术成果奖-学术论文类二等奖, 2006.

2. Isolation and characterization of a novel Burkholderia cepacia with strong antifungal

activity against Rhizoctonia solani. 辽宁省自然科学学术成果奖-学术论文类一等奖, 2007.