刘志敏^1,,
刘天卿¹,
王红龙¹,
刘楠^2,,
1. 大连市友谊医院 病理科, 辽宁 大连 116001
2. 大连医科大学附属第二医院 内分泌1科, 辽宁 大连 116027

详细信息 作者简介: 刘志敏(1979-), 女, 副主任医师。E-mail: liuzm789@163.com




通讯作者: 刘楠, 副主任医师。E-mail: liunanyy@163.com 中图分类号: R736.1


摘要:目的探讨肿瘤相关巨噬细胞浸润及CD47蛋白表达与甲状腺乳头状癌患者临床病理特征间的关系及意义。方法收集大连市友谊医院2015—2019年间甲状腺乳头状癌手术切除标本65例，应用免疫组织化学方法检测所有标本中CD68⁺和CD163⁺肿瘤相关巨噬细胞浸润和CD47蛋白表达情况，分析肿瘤相关巨噬细胞浸润、CD47蛋白表达与甲状腺乳头状癌患者临床病理特征间的关系，以及肿瘤相关巨噬细胞与CD47蛋白表达的相关性。结果CD68⁺肿瘤相关巨噬细胞阳性率为35.38%，与肿瘤体积及淋巴结转移有关（P < 0.05）；CD163⁺肿瘤相关巨噬细胞阳性率为16.92%，与癌侵犯甲状腺外组织情况有关（P < 0.05）。CD47蛋白阳性表达率为20.00%。CD68⁺和CD163⁺肿瘤相关巨噬细胞浸润与CD47表达均无关联（P>0.05）。结论CD68⁺肿瘤相关巨噬细胞可能促进甲状腺乳头状癌进展，而CD163⁺肿瘤相关巨噬细胞可能抑制其进展。
关键词: 甲状腺乳头状癌/
CD68⁺肿瘤相关巨噬细胞/
CD163⁺肿瘤相关巨噬细胞/
CD47


Abstract:ObjectiveTo explore the significance of tumor-associated macrophages (TAMs) infiltration and CD47 protein expression in papillary thyroid cancer (PTC).MethodsA total of 65 cases of PTC specimens were collected in Dalian Municipal Friendship Hospital during 2015-2019. Immunohistochemical staining was used to detect the infiltration of CD68⁺ and CD163⁺ TAMs, and the expression of CD47 protein in all specimens. The relationships between CD68⁺ TAMs infiltration, CD163⁺ TAMs infiltration, CD47 protein expression and clinicopathological features of PTC patients, and correlations of CD68⁺ TAMs and CD163⁺ TAMs with CD47 protein in PTC were analyzed.ResultsTAMs with CD68 positive (35.38%) was associated with tumor size and lymph node metastasis (P < 0.05). TAMs with CD163 positive (16.92%) was associated with extrathyroidal extension situation (P < 0.05). CD47 protein expression (20.00%) had no relevance with CD68⁺ TAMs or CD163⁺ TAMs infiltration (P>0.05).ConclusionsThe CD68⁺ TAMs may play a promotive role in PTC progression, however CD163⁺ TAMs may play a suppressive one.
Keywords:PTC/
CD68⁺ TAMs/
CD163⁺ TAMs/
CD47

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https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20210104