王旭刚^1,,
那力荣²,
高政^1,,
1. 大连医科大学附属第二医院 神经内科, 辽宁 大连 116027
2. 大连医科大学 研究生院, 辽宁 大连 116044

详细信息 作者简介: 王旭刚(1983-), 男, 副主任医师。E-mail: 17709876227@163.com



通讯作者: 高政, 教授。E-mail: bygzyz@163.com 中图分类号: R743.3;R587.1


摘要:目的研究2型糖尿病（diabetes mellitus type 2，T2DM）与非T2DM的急性脑梗死患者非痴呆性血管性认知障碍（vascular cognitive impairment no dementia，VCIND）的相关因素差异。方法连续选择发病2周以内的，首次诊断为急性脑梗死患者，将其中符合VCIND诊断对象入组，登记入组患者一般情况、生物学因素及检查结果，再将所有入组患者分为T2DM组与非T2DM组，对两组患者一般情况、生物学因素及检查结果、MoCA量表等情况进行比较分析。结果T2DM组与非T2DM组比较，T2DM组颈动脉粥样硬化患者比例高，两组间比较差异有统计学意义（P=0.002，P < 0.01）；T2DM组MoCA量表总得分低，两组间比较差异有统计学意义（P=0.047，P < 0.05）；各分项得分中，T2DM组执行功能得分更低（P=0.025，P < 0.05），记忆功能得分更低（P=0.001，P < 0.01）；其他各分项得分均无统计学差异。结论T2DM与非T2DM急性脑梗死患者VCIND比较发现，T2DM组颈动脉粥样硬化患者比例高，认知功能损伤更重。
关键词: 2型糖尿病/
急性脑梗死/
非痴呆性血管性认知障碍/
MoCA量表


Abstract:ObjectiveTo investigate the different factors related to vascular cognitive impairment no dementia (VCIND) in T2DM and non-T2DM patients complicated with acute cerebral infarction.MethodsPatients, who was diagnosed with acute cerebral infarction for the first time (within 2 weeks of onset) and met the classification and diagnostic criteria of Guidelines for Diagnosis and Treatment of Vascular Cognitive Impairment formulated by dementia and cognitive impairment group of neurology branch of the Chinese Medical Association (2011 edition), were enrolled in the study. Clinical data on the general condition, biological factors and lab results were reviewed. The patients were divided into two groups, T2DM group and non-T2DM group. The differences of the general conditions, biological factors, total score of MoCA scale, and various parts of MoCA between the two groups were compared.ResultsIn comparison between T2DM and non-T2DM groups, the proportion of patients with carotid atherosclerosis in T2DM group was higher (P=0.002), the total MoCA score was lower in T2DM group (P=0.047). Compared with non-T2DM group, the scores of executive test and memory test in T2DM group were lower (P=0.025 and P=0.001, respectively). There were not statistically significant differences in other scores.ConclusionComparision of VCIND in T2DM and non-T2DM patients with acute cerebral infarction demonstrates that the proportion of patients with carotid atherosclerosis in T2DM group is higher, and the cognitive impairment is more serious.
Keywords:T2DM/
acute cerebral infarction/
vascular cognitive impairment not dementia/
MoCA scale

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