王智力^1,,
卢书明¹,
杨柳^2,,
1. 大连医科大学附属第一医院 消化内科，辽宁 大连 116011
2. 大连医科大学 口腔医学院，辽宁 大连 116044

详细信息 作者简介: 王智力(1996-)，女，硕士研究生。E-mail：qadwantstl@sina.com



通讯作者: 杨柳，讲师。E-mail: yangliuihb@163.com 中图分类号: R575.5


摘要:目的探讨幽门螺杆菌(Hp)感染与非酒精性脂肪肝(NAFLD)及血脂代谢的相关性。方法回顾性分析2019年1月至12月于大连医科大学附属第一医院消化内科住院行Hp检测患者的临床资料，共纳入患者848例，其中Hp阳性组746例，Hp阴性组102例，对两组中NAFLD患者占比及其BMI、血浆总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)结果进行分析。结果Hp阳性组NAFLD患者占比为14.2%，高于Hp阴性组6.9%，Hp阳性组患者BMI、血TG和UA均值高于Hp阴性组，差异均有统计学意义(P < 0.05)，两组患者TC、LDL-C、HDL-C均值比较差异无统计学意义(P>0.05)。结论Hp感染与NAFLD之间密切相关，可能与肥胖、血脂及血尿酸异常等有关。
关键词: 幽门螺杆菌/
脂肪肝/
非酒精性/
血脂/
血尿酸


Abstract:ObjectiveTo investigate the relationship between Helicobacter pylori (Hp) infection and non-alcoholic fatty liver disease (NAFLD) or lipid metabolism.MethodsThe clinical data of patients, who were admitted and examined for Hp infection in the Department of Gastroenterology at the First Affiliated Hospital of Dalian Medical University from January 2019 to December 2019, were retrospectively analyzed. Totally 848 patients were enrolled in this study, including 746 patients in the Hp positive group and 102 patients in the Hp negative group. The proportion of patients with non-alcoholic fatty liver disease (NAFLD) and levels of BMI, plasma total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and blood uric acid (UA) were analyzed and compared between the two groups.ResultsThe proportion of NAFLD patients in the Hp positive group was 14.2%, higher than that in the Hp negative group (6.9%). The mean values of BMI, TG and UA in the Hp positive group were higher than those in the Hp negative group (P < 0.05), while there were no significant differences in the mean values of TC, LDL-C and HDL-C between the two groups (P>0.05).ConclusionHp infection is closely correlated with NAFLD, and may be associated with obesity, abnormal blood lipids and uric acid.
Keywords:Helicobacter pylori/
fatty liver disease/
non-alcoholic/
lipid metabolism/
uric acid

PDF全文下载地址:

https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20220110