任萍萍^1,2,,
段志军^1,,
1. 大连医科大学附属第一医院 消化内科，辽宁 大连 116011
2. 大连医科大学附属第二医院 消化内科，辽宁 大连 116027

详细信息 作者简介: 任萍萍(1988-)，女，主治医师。E-mail：17709870682@163.com


通讯作者: 段志军，教授。E-mail：cathydoctor@sina.com 中图分类号: R57


摘要:血红素氧合酶-1(hemeoxygenase-1, HO-1)是血红素代谢过程中的限速酶，催化血红素裂解生成等分子的一氧化碳(carbon monoxide, CO)、胆绿素和Fe²⁺。HO-1是一种公认的保护剂，具有抗炎、抗氧化的作用，并参与调控细胞增殖、凋亡、自噬等重要生命过程，对各种不同组织的创伤均具有保护作用。多项研究显示，HO-1在非甾体抗炎药(non-steroidal anti-inflammatory drugs, NSAIDs)相关性消化道损伤、炎症性肠病(inflammatory bowel disease, IBD)、肠缺血再灌注损伤、消化道肿瘤、胃瘫等多种消化道疾病中均有适应性表达，并起到保护胃肠组织和细胞的重要作用。本文就HO-1在消化道疾病防治中的作用及机制研究进行综述。
关键词: 血红素氧合酶-1/
炎症性肠病/
消化道肿瘤/
缺血/再灌注损伤


Abstract:Hemeoxygenase-1 (HO-1) is a rate-limiting enzyme in heme metabolism, which cleaves heme into equimolar quantities of carbon monoxide (CO), biliverdin and Fe²⁺.HO-1 is a recognized protective agent, which has anti-inflammatory and antioxidant effects and participates in the regulation of cell proliferation, apoptosis, autophagy and other important life processes, and plays a protective role in various tissue injuries. Multiple studies have shown that HO-1 plays an important role in protecting gastrointestinal tissues and cells and has adaptive expression in a variety of gastrointestinal diseases including non-steroidal anti-inflammatory drugs (NSAIDs) related gastrointestinal injury, inflammatory bowel disease disease(IBD), intestinal ischemia-reperfusion injury, gastrointestinal tumor, gastroparesis. We reviewed the role and mechanism of HO-1 in the prevention and treatment of gastrointestinal diseases.
Keywords:hemeoxygenase-1/
inflammatory bowel diseases/
gastrointestinal tumor/
ischemia/reperfusion injury

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https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20220114