罗雅尹,
宋春莉,
王哲,
韩杰^,
大连医科大学附属第一医院 神经内科，辽宁 大连 116011

详细信息 作者简介: 罗雅尹（1989-），女，主治医师。E-mail：dlluoyayin@163.com




通讯作者: 韩 杰，教授。E-mail：hjj.427@163.com 中图分类号: R743.32


摘要:肠道菌群在人类健康和疾病中发挥重要作用，微生物群-肠-脑轴使肠道菌群与中枢神经系统之间实现双向通信。肠道菌群失调与肥胖、糖尿病、高血压和动脉粥样硬化等缺血性脑卒中危险因素的发生有关，增加缺血性脑卒中风险；而脑卒中这一急性应激使肠道菌群的组成和丰度也发生了变化，并且可能影响卒中预后。本综述总结了肠道菌群失调介导脑卒中危险因素发生的临床和临床前研究证据，以及动物实验和临床人群中观察到的随着脑卒中发病而出现的肠道菌群变化特点。这种改变与卒中后感染和神经功能预后相关，其机制包括肠道屏障破坏、产生内毒素、诱发免疫炎症反应、代谢产物异常等。
关键词: 肠道菌群/
微生物群-肠-脑轴/
缺血性脑卒中


Abstract:Gut microbiota play important roles in human health and diseases. The microbiota-gut-brain-axis (MGBA) is a bidirectional communication network between gut microbiota and their host. Dysbiosis is related to the development of common stroke risk factors such as obesity, diabetes, hypertension and atherosclerosis, increasing the risk of ischemic stroke. The acute stress of stroke also changes the composition and quantity of gut microbiota, which may affect the prognosis of stroke. In this review, the current clinical and preclinical evidence for the role of gut microbiota in the development of stroke risk factors are summarized, as well as microbiota alterations in association with stroke in experimental and clinical populations. Dysbiosis is related to post-stroke infection and functional outcome, and the mechanisms include destruction of intestinal barrier, production of endotoxin, induction of immune inflammatory response, abnormality of metabolites, etc.
Keywords:gut microbiota/
microbiota-gut-brain axis/
ischemic stroke

PDF全文下载地址:

https://journal.dmu.edu.cn/data/article/export-pdf?id=640aa3f2fa89b2af1f87251f