王翠翠,
赵辉^,
大连医科大学附属第二医院 健康管理中心，辽宁 大连 116027

基金项目: 辽宁省教育厅研究课题(LZ2020009)


详细信息 作者简介: 王翠翠(1995-)，女，硕士研究生。E-mail：wcc1453443281@163.com


通讯作者: 赵辉，教授。E-mail：zhaohui@dmu.edu.cn 中图分类号: R589.1


摘要:目的探究大连地区健康体检人群血清25-(OH)-D₃水平与空腹血糖受损的关系。方法筛选出2020年1月1日至2020年12月15日在大连医科大学附属第二医院健康管理中心体检并符合纳排标准的体检者3 069例。收集整理体检者的数据资料进行横断面研究。依据空腹血糖受损情况分为对照组和空腹血糖受损组，比较性别、年龄、空腹血糖、血清25-(OH)-D₃、高血压和(或)血压高、糖尿病家族史、甲状腺结节和(或)囊肿、脂肪肝、血压、腹围、体重指数、血常规、肝功能、尿酸、血脂等变量的组间差异性，并分析血清25-(OH)-D₃水平与空腹血糖受损的相关性。按血清25-(OH)-D₃水平分为缺乏组(＜20 ng/mL)、不足组(20~30 ng/mL)和适宜组(＞30 ng/mL)，并采用多因素二元logistic回归方法，创建4种不同模型，分析不同25-(OH)-D₃分组与空腹血糖受损的优势比(OR)及95%置信区间(95%CI)。结果在本研究中，除外糖尿病家族史、甲状腺结节和/或囊肿、球蛋白、总胆红素、直接胆红素5个变量外，余变量在对照组和空腹血糖受损组间均具有显著差异性; 血清25-(OH)-D₃水平与空腹血糖受损呈正相关(r=0.112，P＜0.001);与25-(OH)-D₃缺乏组相比，在未调整任何变量时，不足组和适宜组的空腹血糖受损的OR(95%CI)为1.60(1.36~1.87)和1.58(1.16~2.14)。在调整众多变量后，不足组和适宜组的空腹血糖受损的OR(95%CI)为1.41(1.17~1.70)和1.44(1.01~2.05)。结论血清25-(OH)-D₃水平升高可能促进空腹血糖受损的发生，管理25-(OH)-D₃水平或促进25-(OH)-D₃向活性形式1, 25-(OH)₂-D₃的转化可能是预防空腹血糖受损的新措施。
关键词: 健康体检/
25-(OH)-D₃/
空腹血糖受损/
相关性


Abstract:ObjectiveTo explore the correlation between serum 25-(OH)-D₃ and impaired fasting glucose (IFG) in healthy population in Dalian.MethodsA total of 3 069 healthy individuals were enrolled, who underwent physical examination in the Health Management Center of the Second Hospital of Dalian Medical University from January 1 to December 15, 2020 and met the inclusion and exclusion criteria. We collected the data and conducted a cross-sectional study. The participates were divided into control group and IFG group according to whether fasting blood glucose was impaired. The difference of each variable was compared between the two groups, including gender, age, fasting blood glucose, serum 25-(OH)-D₃, hypertension and/or elevated blood pressure, family history of diabetes, thyroid nodules and/or cysts, fatty liver, blood pressure, abdominal circumference, body mass index, blood routine, liver function, uric acid, blood lipids and other variables. The correlation between serum 25-(OH)-D₃ level and IFG was analyzed. According to serum level of 25-(OH)-D₃, all subjects were further divided into three groups: deficiency (< 20 ng/mL), insufficient (20-30 ng/mL) and optimum (>30 ng/mL). Using deficiency group as control, odds ratio (OR) and 95% confidence interval (95%CI) for the risk of IFG were analyzed in the other two groups using multivariate binary logistic regression analysis by four different models.ResultsExcept the 5 variables of diabetic family history, thyroid nodule and/or thyroid cyst, globulin, total bilirubin, and direct bilirubin, the remaining variables showed significant differences between control and IFG groups. Serum 25-(OH)-D₃ level was positively correlated with IFG (r=0.112, P < 0.001). Compared with the 25-(OH)-D₃ deficiency group, the OR (95%CI) for IFG in both insufficient and optimum groups were 1.60(1.36-1.87) and 1.58(1.16-2.14). After adjusting for many variables, the OR (95%CI) for IFG was 1.41 (1.17-1.70) in insufficient group and 1.44 (1.01-2.05) in optimum group.ConclusionsElevated serum 25-(OH)-D₃ profile may be a contributing factor to IFG, and management of serum 25-(OH)-D₃ or promoting the conversion of 25-(OH)-D₃ to the active form 1, 25-(OH)₂-D₃ may be a new measure to prevent IFG.
Keywords:health examination/
25-(OH)-D₃/
impaired fasting glucose/
correlation

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