付雅,
生杰^,
大连医科大学附属第二医院 肾内科，辽宁 大连 116027

详细信息 作者简介: 付雅(1993-)，女，住院医师。E-mail: fuya01200418@163.com


通讯作者: 生杰，主任医师。E-mail: shengjie009@126.com 中图分类号: R692.3⁺¹


摘要:IgA肾病(immunoglobulin A nephropathy, IgAN)是一种常见的肾小球疾病，既往认为妊娠可能会加重IgAN进展。本文从妊娠期间血流动力学变化、妊娠期间体内激素、细胞因子变化以及IgAN发病过程中T细胞的作用等多种角度综述妊娠对IgAN的影响，同时结合目前的临床研究证明当满足一定条件时，妊娠并不会加重IgAN的进展。
关键词: IgA肾病/
妊娠/
雄激素/
调节性T细胞/
白细胞介素6


Abstract:Immunoglobulin A nephropathy (IgAN) is A common glomerular disease. It was previously thought that pregnancy may aggravate the progression of IgAN. In this paper, from the perspectives of hemodynamic changes during pregnancy, changes of hormones and cytokines during pregnancy and the role of T cells in the pathogenesis of IgAN, we review the effects of pregnancy on IgAN. At the same time, combining with current clinical studies, we will demonstrate that pregnancy does not aggravate the progression of IgAN when certain conditions are met.
Keywords:IgA nephropathy/
pregnancy/
androgens/
regulatory T cells/
interleukin 6

PDF全文下载地址:

https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20220215