武亚琴,
张超杰^,
湖南师范大学附属第一医院 湖南省人民医院 乳甲外科, 湖南 长沙 410005

基金项目: 吴阶平医学会基金项目(320.6750.17248)


详细信息 作者简介: 武亚琴(1996-), 女, 硕士研究生。E-mail:wuyaqin1996@163.com


通讯作者: 张超杰, 教授。E-mail:zhangchaojie74@126.com 中图分类号: R737.9


摘要:乳腺神经内分泌癌（neuroendocrine carcinoma of breast，NEBC）是一种临床上较为罕见的乳腺肿瘤，尚缺乏明确的规范化诊疗指南，该病的组织起源尚不明确，目前主要有三种观点，其中，NEBC可能是乳腺干细胞分化为神经内分泌和上皮细胞的早期结果这一观点更被接受。NEBC临床特征及病理特征稍突出，但影像学表现不具特异性，单凭影像学难以与其他类型乳腺癌鉴别。NEBC诊断方法已经较为明确，确诊依靠病理学检查中神经内分泌标志物的检测。治疗原则为以手术为主、全身治疗为辅的综合治疗，相较于其他类型乳腺癌，NEBC的疗效较差。因此，寻求特异性高的治疗方法成为当今NEBC研究的主流，多个研究着手于对NEBC基因突变的检测，力求研发出针对其高频突变位点的靶向治疗药物。同时，NEBC预后较差，确诊该病后，应积极治疗并坚持随访，及时发现疾病新的变化或进展。
关键词: 神经内分泌肿瘤/
乳腺癌/
非特殊类型乳腺癌


Abstract:A rare clinical breast tumor, neuroendocrine carcinoma of breast(NEBC), is still a lack of clear guidelines for standardization, the tissue origin of which is unclear. There are three main opinions, among which NEBC is more likely to be an early result of the differentiation of breast stem cells into neuroendocrine and epithelial cells. The clinical and pathological features of NEBC are slightly prominent, however, the imaging manifestations are not specific. It is difficult to distinguish NEBC from other types of breast cancer by imaging alone. The methods of diagnosis have been relatively clear, which depends on the detection of neuroendocrine markers in pathological examination. Principle of treatment is a type of comprehensive treatment mainly by operation and supplemented by systemic treatment. Which opposed to other types of breast cancer, curative effect of NEBC is poorer. Therefore, to seek high specificity of treatment has become the mainstream of the current research on NEBC. More and more research has worked on detection of NEBC gene mutations, strove to develop targeted therapy drugs against its high-frequency mutations. At the same time, the prognosis of NEBC is poor. We should treat it and follow up actively after the diagnosis of this disease, to detect new changes or progression of the disease timely.
Keywords:neuroendocrine carcinoma of breast/
breast cancer/
non-specific breast cancer

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