吴迪,
李英豪,
赵宁,
刘斌,
吉林大学第二医院 心内科, 吉林 长春 130000
详细信息 作者简介: 吴迪(1994-), 男, 硕士研究生。E-mail:wudi023@foxmail.com
通讯作者: 刘斌, 教授。E-mail:liubin3333@vip.sina.com 中图分类号: R593.2
摘要:抗磷脂综合征(antiphospholipid syndrome,APS)是一种全身性的自身免疫性疾病,以血管血栓形成或妊娠并发症为特征,伴有持续阳性的抗磷脂抗体(aPL),包括狼疮抗凝物(LA),抗心磷脂抗体(aCL)和抗β2-糖蛋白Ⅰ(β2GPI)抗体。目前血栓性APS的治疗包括血栓事件的一级及二级预防、复发血栓、产科并发症以及灾难性抗磷脂综合征的治疗。本文对血栓性APS治疗方案的更新及主要研究进展进行综述。
关键词: 血栓性/
抗磷脂抗体/
抗磷脂综合征
Abstract:Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by vascular thrombosis, complications during pregnancy, and persistent positive antiphospholipid antibodies (APL) including lupus anticoagulant (LA), anticardiolipin antibodies (ACL) and anti β 2-glycoprotein Ⅰ (β 2GPI). At present, the treatment for thrombotic APS includes primary and secondary thromboprophylaxis and treatment for recurrent thrombus, obstetric complications and catastrophic antiphospholipid syndrome. The purpose of this article is to review updated treatment for thrombotic APS, focusing on the research progress in recent years.
Keywords:thrombotic/
antiphospholipid antibody/
antiphospholipid syndrome
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