姜丹妮^1,,
聂小毳^2,,
1. 大连医科大学 研究生院, 辽宁 大连 116044
2. 沈阳市妇婴医院 妇科, 辽宁 沈阳 110001

详细信息 作者简介: 姜丹妮(1995-), 女, 硕士研究生。E-mail: 728215575@qq.com


通讯作者: 聂小毳, 主任医师。E-mail: xiaocui_nie@163.com 中图分类号: R714.21


摘要:先兆流产是女性妊娠期的常见并发症，半数左右将进展为自发流产，严重影响女性身心健康。孕激素在维持妊娠中具有重要作用，多年来作为一种经典药物被用于先兆流产患者防止妊娠丢失。常用给药途径包括口服给药、肌肉注射及经阴道给药等。尽管孕激素用于治疗先兆流产已近70年，至今仍无确凿证据支持其疗效。本文通过结合近年来国内、外相关领域研究进展，综合评价孕激素在先兆流产患者中的治疗效果，并探索不同制剂、用药途径之间是否存在差异，旨在为临床应用提供参考借鉴。
关键词: 孕激素/
地屈孕酮/
黄体酮/
先兆流产


Abstract:Threatened abortion is a common issue during pregnancy which might progress to spontaneous miscarriage in half individuals with the condition and thought to affect the physical and mental health of women, considerably. In clinical treatment for patients with threatened abortion, progestogen is a usual option to prevent pregnancy loss due to its effects on maintaining pregnancy.The most utilized routes are oral, the intramuscular and vaginal administration.Despite the extensive use of progestogen in the past seventy years, no definite evidence to date has been reported on its efficiency.Combining the domestic and international research progress of the related field in recent years, this article comprehensively evaluates the therapeutic effect of progesterone in patients with threatened abortion and explores whether there are differences between preparations and administration routes, in order to provide reference for its clinical application.
Keywords:progestogen/
dydrogesterone/
progesterone/
threatened abortion

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https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20210315