石晓毅^1,,
姜春萌^2,,
1. 大连医科大学 研究生院，辽宁 大连 116044
2. 大连医科大学附属第二医院 消化一科，辽宁 大连 116027

详细信息 作者简介: 石晓毅（1997-），女，住院医师。E-mail：15849164327@163.com


通讯作者: 姜春萌，教授。E-mail：jcmocean@163.com 中图分类号: R392


摘要:自噬是细胞质物质传递到溶酶体并在溶酶体中降解的过程，能够维持细胞内环境的稳定。自噬受到多种因素的调控，脂代谢与自噬密切相关。SCD1是一种中枢脂肪生成酶，是控制脂肪生成的潜在靶点，其在自噬中发挥重要作用，包括促进自噬体的形成，以及通过脂类生成、脂阀-AKT-FOXO1途径、AMPK途径、影响自噬体-溶酶体融合等方式调节自噬等。本文就SCD1在自噬中的作用进行综述。
关键词: 自噬/
脂代谢/
SCD1


Abstract:Autophagy is a process in which cytoplasmic substances are transferred to and degraded in lysosomes. It can maintain the stability of the intracellular environment and is regulated by multiple factors. Lipid metabolism is closely related to autophagy. SCD1, a central fat generating enzyme and a potential target for controlling fat generation, plays an important role in autophagy, including promoting the formation of autophagosomes and regulating autophagy through lipogenesis, lipid rafts-coupled AKT-FOXO1 signaling pathway, AMPK pathway, and affecting autophagosome-lysosomal fusion. This article reviews the research progress on the role of SCD1 in autophagy.
Keywords:autophagy/
lipid metabolism/
SCD1

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https://journal.dmu.edu.cn/data/article/export-pdf?id=64b9efedfa89b263238914d2