杨俊婷^1,,
王昱蘅¹,
郭慧淑²,
蔡正旭^1,,
1. 大连医科大学附属第一医院 神经内科，辽宁 大连 116011
2. 大连医科大学附属第一医院 中心实验室，辽宁 大连 116011

详细信息 作者简介: 杨俊婷（1996-），女，硕士研究生。E-mail：15288464564@163.com




通讯作者: 蔡正旭，主任医师。E-mail：caizhengxu999@126.com 中图分类号: R741


摘要:癫痫是一种常见的大脑疾病，其发病机制复杂多样，至今尚未完全明确。但随着电生理学技术的发展，越来越多的研究结果揭示了癫痫与离子通道的联系。离子通道是神经系统兴奋性产生与调节的关键因子，Na_V1.6作为电压门控钠通道（VGSCs）的亚型之一，其介导的持续性Na⁺电流（I_NaP）和复活性Na⁺电流（I_NaR）是神经元兴奋性的重要组成。Na_V1.6通道表达量的改变及基因突变引起的功能异常均在癫痫中发挥重要作用，可见Na_V1.6通道功能障碍是癫痫发病机制之一。通过对该通道的进一步研究有助于了解癫痫的发病机制，并找到有效的治疗方法。
关键词: 癫痫/
发病机制/
Na_V1.6


Abstract:Epilepsy is a common brain disease, and its pathogenesis is complex and unclear.With the development of electrophysiological technology, more and more research results reveal the connection between epilepsy and ion channels. Ion channels are key factors in the generation and regulation of excitability in the nervous system. As one of the subtypes of voltage-gated sodium channels (VGSCs), Na_V1.6 mediates persistent Na⁺ current (I_NaP) and reactivated Na⁺ current (I_NaR), which is one of the important components of neuronal excitability. Changes in the expression of Na_V1.6 channel and functional abnormalities caused by gene mutation play an important role in epilepsy. Further research on this channel will help to understand the pathogenesis of epilepsy and find effective treatments.
Keywords:epilepsy/
pathogenesis/
Na_V1.6

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