柴淑芳^1,,
李俊琴²,
张志祥¹,
李新华^2,,
1. 山西医科大学附属第九临床医学院 皮肤科，山西 太原 030000
2. 山西医科大学附属太原中心医院 皮肤科实验室，山西 太原 030000

基金项目: 中央引导地方科技发展专项资金项目（YDZX20191400004470）；山西省医学重点科研项目（2020XM20）；太原市科技项目（202213）


详细信息 作者简介: 柴淑芳（1998-），女，硕士研究生。E-mail：csfcsf0321@163.com




通讯作者: 李新华，主任医师。E-mail：tylixinhua@sina.com 中图分类号: R758.63


摘要:银屑病是常见的慢性炎症性皮肤病之一，以角质形成细胞过度增殖为特征。磷脂酰肌醇3激酶（PI3K）/蛋白激酶B （PKB，又称AKT）信号通路在细胞增殖和存活等多种细胞功能中起着核心作用。FOXO转录因子受PI3K/AKT信号通路负向调控，被认为对细胞增殖有抑制作用。PI3K/AKT信号分子的上游和下游，如肿瘤抑制因子磷酸酶和张力蛋白同源物（PTEN）和雷帕霉素靶蛋白（mTOR）的表达在银屑病中也经常发生改变。本文重点介绍PI3K、AKT与下游靶点FOXO在银屑病中的作用，同时总结PI3K/AKT/FOXO信号传导及其上下游分子作为银屑病治疗靶点的机制，以期为银屑病的治疗提供新的方向。
关键词: 银屑病/
PI3K/AKT/FOXO信号通路/
发病机制/
抑制剂


Abstract:Psoriasis is one of the common chronic inflammatory skin diseases, characterized by hyperproliferative keratinocytes. The phosphatidylinositol 3 kinase (PI3K) and protein kinase B (AKT) signaling pathway plays a central role in multiple cellular functions such as cell proliferation and survival. The forkhead box O (FOXO) transcription factors are negatively regulated by the PI3K/AKT signaling pathway and considered to have an inhibitory effect on cell proliferation. The upstream and downstream of PI3K/AKT signaling molecules such as tumor suppressor phosphatase and tensin homolog (PTEN) and mammalian target of Rapamycin (mTOR), are also frequently altered in psoriasis, respectively. In this review, we highlight the recent studies on the roles and mechanisms of PI3K/AKT and the downstream targets FOXO in psoriasis. At the same time, we have summarized PI3K/AKT/FOXO signaling and its upstream and downstream molecules, which could be novel therapeutic targets for psoriasis and provide a new direction for the treatment of psoriasis.
Keywords:psoriasis/
PI3K/AKT/FOXO signaling pathway/
pathogenesis/
inhibitor

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https://journal.dmu.edu.cn/data/article/export-pdf?id=65090eacfa89b2fe327f3315