徐晓晨^1,2,,
翟恒博³,
张波¹,
王燕娥¹,
刘俊¹,
董志超^1,,
1. 大连医科大学附属第一医院 心内科, 辽宁 大连 116011
2. 郑州大学附属郑州中心医院 心内科, 河南 郑州 450000
3. 北部战区总医院 心内科, 辽宁 沈阳 110016

基金项目: 辽宁省省直医院改革重点临床科室诊疗能力建设项目（LNCCC-D18-2015）；大连市科技计划项目（2015E12SF168）


详细信息 作者简介: 徐晓晨(1989-), 女, 住院医师。E-mail:xxclingqi2013@163.com






通讯作者: 董志超, 主治医师。E-mail:dongzhichaomed@163.com 中图分类号: R541.4


摘要:目的分析大连地区冠心病患者的血脂基线水平及近10年的变化趋势。方法回顾性分析2013—2014年及2003—2004年入住大连医科大学附属第一医院心内科行冠状动脉造影术的患者4 279例，分析冠心病患者血脂基线水平现况、在不同人群中的差别以及10年前后血脂的变化趋势。结果与10年前冠心病患者比较，2013—2014年冠心病患者高胆固醇（TC）血症的比例明显下降（7.8% vs.10.6%，P=0.019），TC及高密度脂蛋白胆固醇（HDL-C）水平明显下降（P均 < 0.001），甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）及非高密度脂蛋白胆固醇（non-HDL-C）水平无显著差异（P均>0.05）；2013—2014年女性冠心病患者TC、TG、LDL-C、HDL-C、non-HDL-C均高于男性患者（P均 < 0.05）；随着年龄的增长，2013—2014年冠心病患者尤其是男性患者TC、TG、LDL-C、HDL-C、non-HDL-C水平均逐渐下降（P均 < 0.05），女性患者血脂水平变化不明显（P均>0.05）。结论与10年前相比，尽管大连地区冠心病患者近些年血脂水平呈下降趋势，但血脂组成构成并没有得到改善，应进一步重视冠心病患者不同性别、年龄的血脂变化。
关键词: 冠心病/
血脂/
趋势


Abstract:ObjectiveTo explore and analyze serum lipids levels and trend of change in patients with coronary heart disease (CHD) in recent decade in Dalian, China.MethodsA retrospective analysis of 4 279 patients, who were admitted and underwent coronary angiography at the First Affiliated Hospital of Dalian Medical University between 2003-2004 and 2013-2014, was performed. Serum lipids levels were analyzed according to the CHD patients' gender, age, and disease patterns. The trends of serum lipid levels in patients with CHD were studied in recent decade.ResultsCompared to ten years ago, the percentages of patients with hypercholesterolemia in 2013-2014 decreased from 10.6% to 7.8%(P=0.019). The levels of TC and HDL-C in CHD patients in 2013-2014 were lower than those in 2003-2004 (P < 0.001), and there were no differences in the levels of TG, LDL-C and non-HDL-C(all P>0.05). Compared with male CHD patients, there were higher levels of TC, TG, LDL-C, HDL-C and non-HDL-C in female patients (P < 0.05). With the increase of age, the levels of TC, TG, LDL-C, HDL-C and non-HDL-C were declined especially in male CHD patients (P < 0.05) and there were no significant changes in female patients in 2013-2014 (P>0.05).ConclusionThere is a declining trend in several lipid profiles among Dalian CHD patients; however, there is no obvious improvement in the composition of blood lipid. Further attention should be paid to serum lipid changes in CHD patients with different genders and ages.
Keywords:coronary heart disease/
lipid/
trends

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