李盼盼^1,,
张卓^2,,
1. 大连医科大学 研究生院, 辽宁 大连 116044
2. 大连医科大学附属第二医院 肿瘤放疗科, 辽宁 大连 116027

详细信息 作者简介: 李盼盼(1995-), 女, 硕士研究生。E-mail: 15124405198@163.com


通讯作者: 张卓, 教授。E-mail: 799832582@qq.com 中图分类号: R733.4


摘要:原发性中枢神经系统淋巴瘤（primary control nervous system lymphoma，PCNSL）是在脑、脊髓、脑膜或眼发生的罕见侵袭型非霍奇金淋巴瘤，无中枢神经系统之外的部位累及。PCNSL绝大多数来源于B淋巴细胞，极少数来源于T淋巴细胞。90%是弥漫大B细胞型，另有其他少见类型Burkitt或T细胞淋巴瘤。PCNSL占所有非霍奇金淋巴瘤的1%，占原发性颅内肿瘤的3%。目前尚无标准治疗方案。以大剂量甲氨蝶呤为基础的联合化疗已经成为首选治疗手段，巩固治疗主要包括全脑放疗和自体造血干细胞移植。针对PCNSL分子机制的新型治疗药物也取得了很大进展。本文重点对PCNSL目前的治疗研究进展进行综述。
关键词: 原发性中枢神经系统淋巴瘤/
化疗/
放疗


Abstract:Primary central nervous system lymphomas (PCNSLs) are rare invasive non-Hodgkin's lymphomas that occur in the brain, spinal cord, meninges or eyes and are not involving outside of CNS. PCNSLs are mostly derived from B lymphocytes, and a few from T lymphocytes. Diffuse large B-cell type is most common representing 90% of the cases, with other rare types of Burkitt or T-cell lymphoma.PCNSLs account for 1% of all non-Hodgkin's lymphomas and 3% of primary intracranial tumors. At present, there is no standard treatment plan. Combined chemotherapy based on high-dose methotrexatehas been the first choice of treatment.Consolidation therapy mainly includes whole brain radiotherapy and autologous hematopoietic stem cell transplantation.New therapeutic drugs aiming at the molecular mechanisms of PCNSL have also made great progress. This article focuses on the current progress in the treatment of PCNSL.
Keywords:primary central nervous system lymphoma/
chemotherapy/
radiotherapy

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https://journal.dmu.edu.cn/data/article/export-pdf?id=dlykdxxb_20210515