王磊磊,
郭显厅,
王秀莹^,
大连市妇女儿童医疗中心（集团） 妇瘤科，辽宁 大连 116037

详细信息 作者简介: 王磊磊（1997-），女，住院医师。E-mail：957606154@qq.com



通讯作者: 王秀莹，主任医师。E-mail：wxy19720411@163.com 中图分类号: R711.7


摘要:子宫内膜癌（EC）是我国女性生殖系统第二大恶性肿瘤，严重威胁女性健康。随着精准医学的发展，EC的分子病理学成为目前研究热点，尤其是分子分型的提出，为预测患者预后及精准治疗提供了重要指导意义。然而，迄今仍有许多分子机制尚未明确。人类表皮生长因子受体2（HER2）能调节肿瘤细胞的生长、分化以及存活，与多种肿瘤的发生、转移、预后、治疗等密切相关。本文针对HER2在EC发生发展中的作用、检测方法、表达情况、对生存结局的影响以及相关靶向治疗等进展进行综述。
关键词: 人表皮生长因子受体2/
分子分型/
p53异常型子宫内膜癌/
靶向治疗


Abstract:Endometrial cancer is the second most malignant tumor in Chinese women, posing a serious threat to their health. With the development of precision medicine, study of the molecular pathology of endometrial cancer has become a research hotspot, especially the proposal of molecular typing provides important guidance for predicting the prognosis of patients and precision treatment. However, there are still many molecular mechanisms that are not yet clear. Human epidermal growth factor receptor 2 can regulate the growth, differentiation, and survival of tumor cells, and is closely related to the occurrence, metastasis, prognosis, and treatment of various tumors. This article reviews the role, detection methods, and expression of human epidermal growth factor receptor 2 in the occurrence and development of endometrial cancer, as well as its impacts on survival outcomes and related targeted therapies.
Keywords:human epidermal growth factor receptor 2/
molecular typing/
p53 abnormal endometrial cancer/
targeted therapy

PDF全文下载地址:

https://journal.dmu.edu.cn/data/article/export-pdf?id=65645f7cfa89b26c22aba8de