高白冰^1,2,,
卢宇^2,,,
张佳欣^1,2,
王琳³,
韦静³
1. 大连医科大学 研究生院，辽宁 大连 116044
2. 泰州市人民医院 内分泌科，江苏 泰州 225300
3. 泰州市人民医院 产科，江苏 泰州 225300

基金项目: 江苏省“六大人才高峰”高层次人才项目（WSN-336）；江苏省“六个一工程”拔尖人才科研项目（LGY2020067）


详细信息 作者简介: 高白冰（1996-），女，硕士研究生。E-mail：2049525703@qq.com





通讯作者: 卢 宇，副教授。E-mail：luyu_666@126.com 中图分类号: R589


摘要:目的探讨α-Klotho和β-Klotho与妊娠期糖尿病（gestational diabetes mellitus，GDM）及妊娠不良结局的关系。 方法选取GDM患者（GDM组）和糖耐量正常妊娠者（NGT组）各66例，收集两组α-Klotho、β-Klotho、血糖、HbA1c、妊娠结局等指标并进行比较。采用Spearman线性相关分析法分析α-Klotho和β-Klotho与糖代谢指标的相关性，采用logistic回归分析法分析α-Klotho和β-Klotho与GDM及妊娠不良结局的关系。结果GDM组血清α-Klotho和β-Klotho水平低于NGT组（544.94 pg/mL vs 645.98 pg/mL；23.07 pg/mL vs 24.78 pg/mL，P＜0.05）。α-Klotho、β-Klotho水平与FPG及HOMA-IR均呈负相关（P＜0.05），与HOMA-β呈正相关（P＜0.05）。GDM组更易出现妊娠期肥胖和巨大胎儿（P＜0.05）。Logistic回归分析显示，经年龄、BMI、TC、TAG校正后，α-Klotho和β-Klotho均是GDM及巨大胎儿的保护因素（P＜0.05）。结论GDM患者血清α-Klotho和β-Klotho水平降低，且二者均是GDM和巨大胎儿的保护因素，提示α-Klotho和β-Klotho可能参与了GDM及妊娠不良结局的发生过程。
关键词: α-Klotho/
β-Klotho/
妊娠期糖尿病/
妊娠不良结局


Abstract:ObjectiveTo investigate the relationship of α-Klotho, β-Klotho with gestational diabetes mellitus and pregnancy adverse events.MethodsTotally 66 GDM pregnancies (GDM group) and 66 normal pregnancies (NGT group) were selected. The α-Klotho, β-Klotho, blood glucose, HbA1c and other indexes were measured and compared between groups. Spearman linear correlation was used to analyze the correlation between α-Klotho, β-Klotho and glucose metabolism indexes. Logistic regression was performed to analyze the relationship between α-Klotho, β-Klotho and GDM and pregnancy adverse outcomes.ResultsThe serum levels of α-Klotho and β-Klotho in GDM group were lower than those in NGT group (544.94 pg/mL vs 645.98 pg/mL, 23.07 pg/mL vs 24.78 pg/mL, P＜0.05). The α-Klotho and β-Klotho levels were negatively correlated with FPG and HOMA-IR (P＜0.05), while positively correlated with HOMA-β (P＜0.05). GDM group more likely had obesity during pregnancy and macrosomia (P＜0.05). Logistic regression analysis revealed that α-Klotho and β-Klotho were protective factors of GDM and macrosomia after correction of age, BMI, TC, TAG (P＜0.05).ConclusionsThe serum levels of α-Klotho and β-Klotho in GDM pregnancies are decreased, and both of them are protective factors of GDM and macrosomia. It's suggested that α-Klotho and β-Klotho may play roles in the occurrence of GDM and pregnancy adverse events.
Keywords:α-Klotho/
β-Klotho/
gestational diabetes mellitus/
pregnancy adverse events

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