刘琳,
梁战华^,
大连医科大学附属第一医院 神经内科，辽宁 大连 116011

基金项目: 国家自然科学基金项目（81801257）


详细信息 作者简介: 刘 琳（1986-），女，副主任医师。E-mail：linlin_dmu@163.com


通讯作者: 梁战华，教授。E-mail：liangzhanhua@dmu.edu.cn 中图分类号: R741.02


摘要:帕金森病（Parkinson's disease，PD）是中老年常见的神经系统退行性疾病，神经炎症及免疫反应在PD的发病及进展中持续存在。趋化因子不仅参与免疫反应，而且具有调控神经炎症的作用，因此成为近年来各种疾病的研究热点。本文将对趋化因子及受体在PD中的研究进展进行详细综述，旨在为PD的早期诊断及治疗提供新思路和新靶点。
关键词: 帕金森病/
小胶质细胞/
趋化因子


Abstract:Parkinson's disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. Neuroinflammation and immune response persist in the pathogenesis and progression of PD. Chemokines are not only involved in immune responses, but also have important roles in regulating neuroinflammation, therefore they have become a research hotspot for various diseases in recent years. In this article, we will review the research progress of chemokines and their receptors in Parkinson's disease in order to provide new ideas and targets for the early diagnosis and treatment of Parkinson's disease.
Keywords:Parkinson's disease/
microglia/
chemokine

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https://journal.dmu.edu.cn/data/article/export-pdf?id=63bcf865fa89b26d52c94a3c