刘志浩，博士, 副教授，硕士生导师。2014年6月毕业于中国医学科学院&北京协和医学院药物研究所，获得药理学博士学位，现任教于大连医科大学药学院临床药理教研室，是辽宁省药代动力学与药物转运重点实验、辽宁省抗肝炎创新药物工程技术研究中心成员，兼任大连市药学会药理专业委员会委员。主持国家自然基金1项，天然药物活性物质与功能国家重点实验室开放课题1项，大连市高层次人才创新计划1项。入选辽宁省“百千万人才工程”，荣获大连市青年科技之星称号。参编《药理学》、《临床药物代谢动力学》、《微生物耐药的基础与临床》等教材。



研究方向:
1. 药物代谢酶/转运体调控的分子机制及生物学效应
2. 药物转运体及代谢酶介导的药物相互作用
3. 临床前药代动力学及PK/PD研究
4. 先导物早期药代特性快速评价
在研项目:
1.大连市高层次人才创新支持计划，2017RQ066，大黄酸对甲氨蝶呤致大鼠肝、肾损伤的保护作用研究, 2018-2020,在研，主持
2. 天然药物活性物质与功能国家重点实验室开放课题，GTZK201709, 转运体介导的双醋瑞因（二乙酰大黄酸）与甲氨蝶呤发生药物相互作用的药代动力学机制研究，2017-2019，在研，主持
3.国家自然科学基金青年基金，**，MRP2和OAT1/3介导的大黄酸与
甲氨蝶呤发生药物相互作用的药代动力学机制研究，2017/01-2019/12，在研，主持
4. 国家自然科学基金面上项目, **,转运体介导哌拉西林/他唑巴坦及 亚胺培南/西司他丁发生增效减毒药物相互作用的分子药代动力学机制, 2019.1-2022.12，在研，参与
5.国家自然科学基金青年基金，**，超声介导转铁蛋白修饰共载表阿霉素和薯蓣皂苷脂质体微泡复合物双靶向给药系统的构建及其逆转多药耐药研究，2016/01-2018/12，在研，参与
发表文章（第一或通讯作者）:
（1）Tianci Bu, Changyuan Wang, Qiang Meng, Xiaokui Huo, Huijun Sun, Pengyuan Sun, Siqi Zheng, Xiaodong Ma, Zhihao Liu*, Kexin Liu* Hepatoprotective Effect of Rhein against Methotrexate-induced liver toxicity. Eur J Pharmacol. 2018 ; 834 ( ): 266 - 273
（2）Wang C, Li S, Meng Q, Sun X, Li H, Shu X, Sun H, Liu K, Liu Z*, Ma X*. Novel amino acid-substituted diphenylpyrimidine derivatives as potent BTK inhibitors against B cell lymphoma cell lines. Bioorg Med Chem. 2018，26 (14 ): 4179 – 4186
（3）Qi Liu^#，Zhihao Liu^#, Xiaokui Huo,Changyuan Wang,Qiang Meng,Huijun Sun,Pengyuan Sun,Jinyong Peng, Xiaodong Ma, Kexin Liu. Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro. Biomedicine & Pharmacotherapy. 2018，103:915 -922, 2018
（4）Zhang Y, Wang C, Duan Y, Huo X, Meng Q, Liu Z^*, Sun H, Ma X, Liu K^*. Afatinib Decreases P-Glycoprotein Expression to Promote Adriamycin Toxicity of A549T Cells. Journal of Cellular Biochemistry, 2018, 119:414–423
（5）Liu Z^#, Yang Y^#, Sheng L^*, Li Y. Interspecies Variation of In Vitro Stability and Metabolic Diversity of YZG-331, a Promising Sedative-hypnotic Compound. Front. Pharmacol, 2017, Aug 11;8:527
（6）Liu Z^*#, Jia Y, Wang C, Meng Q, Huo X, Sun H, Sun P, Yang X, Ma X, Peng J, Liu K^*. Organic anion transporters 1 (OAT1) and OAT3 meditated the protective effect of rhein on methotrexate-induced nephrotoxicity. Rsc Advances, 2017, 7 (41) : 25461-25468
（7）Qu M^#, Liu Z^#, Zhao D, Wang C, Zhang J, Tang Z, Liu K, Shu X, Yuan H, Ma X^*. Design, synthesis and biological evaluation of sulfonamide- substituted diphenylpyrimidine derivatives (Sul-DPPYs) as potent focal adhesion kinase (FAK) inhibitors with antitumor activity. Bioorg Med Chem. 2017, 25(15): 3989-3996
（8）Wang C^#, Liu Z^#, Sun Y, Chen T, Huo X, Meng Q, Liu Q, Sun H, Sun P, Peng J, Ma X, Liu K^*. A stronger reversal effect of the combination of dasatinib and menadione on P-gp-mediated multidrug resistance in human leukemia K562/Adr cell line. Rsc Advances, 2017, 7: 17227-17235
（9）Z Liu，K Liu^*, Application of Model-Based Approaches to Evaluate Hepatic Transporter-Mediated Drug Clearance: In vitro, In vivo, and In vitro-In vivo Extrapolation, Curr Drug Metab, 2016,17(5):456-468
（10） Liu Z^#, Mi J^#, Yang S, Zhao M, Li Y, Sheng L^*, Effects of P-glycoprotein on the intestine and blood-brain barrier transport of YZG-331, a promising sedative-hypnotic compound, Eur J Pharmacol, 2016, 791: 339-347
（11） Jia Y^#, Liu Z^#, Wang C, Meng Q, Huo X, Liu Q, Sun H, Sun P, Yang X, Ma X, Liu K^*, P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate, Toxicol Appl Pharmacol, 2016, 306:27-35
（12）Jia Y^#, Liu Z^#, Huo X, Wang C, Meng Q, Liu Q, Sun H, Sun P, Yang X, Shu X, Liu K^*, Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro, International Journal of Pharmaceutics, 2015, 495(1): 588-598
（13）Zhihao Liu, Li Sheng,Yan Li^*, Determination of YZG-331 in mouse plasma using liquid chromatography-tandem mass spectrometry, Journal of Chromatography B, 2014, 944: 6-10
（14） Zhihao Liu, Kexin Liu^*, The transporters of intestinal tract and techniques applied to evaluate interactions between drugs and transporters, Asian Journal of Phar-maceutical Sciences, 2013, 8(3): 151–158
（15） 刘志浩, 李 燕^*, 核受体对药物代谢酶和转运体的调控, 药学学报, 2012, 47(12): 1575-1581
（16）Liu Z, Wang C, Liu Q, Meng Q, Cang J, Mei L, Kaku T,Liu K^*,Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo, Peptides, 2011, 32(4): 747-754
（17）刘志浩, 刘克辛^*, 肠道药物转运体及其研究方法, 药学学报, 2011, 46(4): 370-376

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