摘要： 目的 探讨脑死亡供者外周血白细胞介素（IL）-6和IL-10对肾移植受者发生移植肾功能延迟恢复（DGF）的预测作用。方法 回顾性收集21例脑死亡供者和42例肾移植受者的临床资料和血液样本，将受者是否发生DGF作为因变量，评估供者外周血IL-6和IL-10对DGF的预测价值。结果 42例肾移植受者中，10例发生DGF。单因素分析结果显示，DGF组和非DGF组比较，供者的IL-6和血肌酐水平以及供肾的冷缺血时间的差异有统计学意义。受试者操作特征（ROC）曲线显示，供者外周血IL-6和IL-10对肾移植受者发生DGF有一定的预测价值（分别为AUC=0.82，95% CI：0.64~0.99；AUC=0.73，95% CI：0.51~0.95）。在校正供者的血肌酐水平、供肾的冷缺血时间后，IL-6仍对DGF的发生有一定的预测价值。结论 脑死亡供者外周血IL-6可能是肾移植受者术后发生DGF的一个预测因子。

脑死亡供者外周血IL-6和IL-10对移植肾功能延迟恢复的预测作用

李帅¹, 鲍龙¹, 郭闻师¹, 孙平²

1. 锦州医科大学附属第一医院神经外科, 辽宁 锦州 121000;
2. 中国医科大学附属第一医院器官移植/肝胆外科, 沈阳 110001

收稿日期:2023-06-13出版日期:2024-02-28发布日期:2024-01-12
通讯作者:郭闻师E-mail:297752955@qq.com
作者简介:李帅(1981-),男,主任医师,硕士研究生.
基金资助:辽宁省科学技术计划（2022-BS-313）


关键词: 脑死亡供者, 移植肾功能延迟恢复, 肾移植, 白细胞介素-6, 白细胞介素-10
Abstract: Objective To investigate the predictive values of interleukin (IL) -6 and IL-10 in the peripheral blood of donors of brain death for delayed graft function (DGF) in kidney transplant recipients. Methods The clinical data and blood samples of 21 donors of brain death and 42 kidney transplant recipients were retrospectively collected. The predictive values of IL-6 and IL-10 in the peripheral blood of donors for DGF were evaluated using the occurrence of DGF as a dependent variable. Results Among the 42 kidney transplant recipients, 10 developed DGF. Univariate analysis showed that there were significant differences in the IL-6 and creatinine levels in the donors and cold ischemia time of donor kidney between DGF and non-DGF groups. The receiver operating characteristic curve showed that IL-6 and IL-10 in donor peripheral blood had certain predictive values for DGF in kidney transplant recipients (AUC=0.82, 95%CI:0.64-0.99;AUC=0.73, 95%CI:0.51-0.95). Despite adjusting for creatinine level and cold ischemia time, IL-6 still has a certain predictive value for DGF. Conclusion IL-6 in the peripheral blood of donors of brain death may be a predictor of DGF in kidney transplant recipients.
Key words: donor of brain death, delayed graft function, kidney transplantation, interleukin-6, interleukin-10
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