摘要： 胎盘功能障碍可导致早期流产或子痫前期和宫内生长受限等胎盘源性疾病，特殊的病原体（如感染恶性疟原虫）侵袭胎盘后也会导致胎儿和（或）母体健康受损。胎盘合体滋养细胞的细胞外基质（ECM）从胎盘绒毛膜绒毛向外延伸到母体血液中，在分子水平上调节和维持滋养细胞侵袭子宫内膜行为。蛋白聚糖（PG）是ECM的主要成分之一，PG多元化的功能主要归功于附着在其核心蛋白复杂的糖胺聚糖链序列和硫酸化模式，以及核心蛋白独特的性质和动态表达。PG定量和定性变化可反映系统紊乱的严重程度和宿主系统的参与程度。本综述总结了PG在胎盘源性疾病中的表达与功能。PG可能是胎盘源性疾病中可靠的生物标志物。

蛋白聚糖在胎盘源性疾病中的生物标志物作用

李海英^1,2, 吴涛³, 乔宠¹

1. 中国医科大学附属盛京医院妇产科, 沈阳 110004;
2. 大连市妇女儿童医疗中心 (集团) 妇产科, 辽宁 大连 116000;
3. 大连医科大学附属第一医院麻醉科, 辽宁 大连 116000

收稿日期:2023-03-23出版日期:2023-11-30发布日期:2023-11-07
通讯作者:乔宠E-mail:cmulee@163.com
作者简介:李海英(1977-),女,主任医师,博士.
基金资助:国家自然科学基金（81370735）；辽宁省自然科学基金（2020-MS-334）


关键词: 胎盘源性疾病, 蛋白聚糖, 生物标志物
Abstract: Placental disfunction can lead to placental-derived diseases such as early abortion or preeclampsia and limited intrauterine growth. Special pathogens such as Plasmodium falciparum can also cause damage to foetal and (or) maternal health after invading the placenta. The extracellular matrix (ECM) of placental synthetic trophoblastic cells extends outward from placental chorionic villi to the maternal blood, regulating and maintaining the invasion of endometrium behavior of trophoblastic cells at the molecular level. Proteoglycan (PG) is one of the main components of ECM. The diversified functions of PG are mainly due to the complex glycosamine chain sequence and sulphurication patterns attached to its core proteins, as well as the unique properties and dynamic expression of core proteins. Quantitative and qualitative changes in PG can reflect the severity of system disorders and the participation of the host system. This review summarises the expression and function of PG in placental-borne diseases, which may be reliable biomarkers in placental-borne diseases.
Key words: placental-derived disease, proteoglycan, biomarker
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