摘要： 心血管疾病是影响人类健康、导致死亡的重要原因之一。转运RNA衍生片段（tRFs）在心血管疾病的发生、发展中起重要作用，包括参与心肌肥厚的代际遗传，调节血管平滑肌的增殖、迁移和表型转换等。但tRFs的很多作用机制仍不明确，需要大量的研究验证。本文主要概述了tRFs的分类、生物学功能，并对tRFs在心肌肥厚、主动脉夹层、血管平滑肌细胞表型转换中的研究进展进行总结、分析。

转运RNA衍生片段在心血管疾病中的研究进展

崔楠, 张俊哲, 马群, Muisha B Mbikyo, 李昭

中国医科大学附属第一医院心血管内科, 沈阳 110001

收稿日期:2022-06-07出版日期:2023-09-30发布日期:2023-09-02
通讯作者:李昭E-mail:drzhaoli123@163.com
作者简介:崔楠(1990-),女,硕士研究生.
基金资助:国家自然科学基金（81970254）；中华心血管病发展专项基金（Z-2019-42-1908）


关键词: 转运RNA衍生片段, 生物学功能, 心血管疾病
Abstract: Cardiovascular diseases are an important cause of poor human health and death, globally. Studies have shown that transfer RNA derived fragments (tRFs) play an important role in the occurrence and development of cardiovascular diseases, by participating in the intergenerational inheritance of myocardial hypertrophy, and regulating the proliferation, migration, and phenotypic transformation of vascular smooth muscle. However, the mechanisms underlying the potential role of tRFs in cardiovascular diseases are still unclear and need further investigation. This paper summarizes the classification and biological function of tRFs and reviews the progress of research on tRFs in myocardial hypertrophy, aortic dissection, and phenotypic transformation of vascular smooth muscle cells.
Key words: transfer RNA derived fragments, biological function, cardiovascular disease
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