摘要： 目的 探讨肿瘤异常蛋白（TAP）和细胞角蛋白19（CK19）在膀胱癌患者血清中的表达及其临床意义。方法 选取2020年1月至2022年1月我院诊治的膀胱癌患者70例为膀胱癌组；同期我院就诊的膀胱良性疾病患者54例为良性组，同期我院体检健康人群63例为对照组。采用凝集素亲和方法检测TAP，酶联免疫吸附试验（ELISA）检测CK19。比较3组患者血清中TAP和CK19的表达水平，分析膀胱癌患者血清中TAP和CK19之间及与各项临床指标的相关性，受试者操作特征（ROC）曲线预测TAP和CK19单独及联合检测对膀胱癌的诊断价值。结果 与对照组和良性组比较，膀胱癌组血清中TAP和CK19表达显著增高（P<0.001），而对照组与良性组TAP和CK19表达比较无统计学差异（均P>0.05）。膀胱癌患者血清中TAP和CK19的表达与肿瘤直径明显相关（P<0.05）；TAP及CK19表达水平呈正相关（P<0.001）。TAP和CK19联合检测对膀胱癌的诊断价值优于单独检测。结论 膀胱癌患者血清中TAP及CK19呈高表达，肿瘤越大，TAP及CK19表达水平越高，TAP及CK19可作为诊断膀胱癌的肿瘤标志物。此外，TAP和CK19联合检测有助于提高膀胱癌的诊断效能。

膀胱癌患者血清中肿瘤异常蛋白和细胞角蛋白19的表达及其临床意义

邱忠凯, 刘俊龙, 丁全明, 梁伟

本溪市中心医院泌尿外科, 辽宁 本溪 117000

收稿日期:2022-04-14出版日期:2023-07-30发布日期:2023-07-08
通讯作者:梁伟E-mail:liangwei_bx@163.com
作者简介:邱忠凯(1981-),男,主任医师,博士.
基金资助:本溪市中心医院科研人才项目（202021）


关键词: 膀胱癌, 肿瘤异常蛋白, 细胞角蛋白
Abstract: Objective To investigate the expression and clinical significance of tumor abnormal protein（TAP）and cytokeratin 19 （CK19）in serum of patients with bladder cancer. Methods A total of 70 patients diagnosed with bladder cancer in our hospital from January 2020 to January 2022 were enrolled in the bladder cancer group，54 patients diagnosed with benign bladder disease during the same period in our hospital were enrolled in the benign group，and 63 healthy people in our hospital served as the control group. TAP and CK19 were detected using lectin affinity method and enzyme linked immunosorbent assay，respectively，in serum samples from the three groups. The receiver operating characteristic（ROC）curve was used for predicting the diagnostic value of TAP，CK19，and the combination of TAP and CK19，for bladder cancer. Results As compared to the benign and control groups，the expression levels of TAP and CK19 were significantly increased in the bladder cancer group（P<0.001），whereas，there was no significant difference in these levels between the benign and control groups（P>0.05）. The expression levels of TAP and CK19 significantly correlated with tumor diameter（P<0.05）. TAP and CK19 were positively correlated in the serum of patients with bladder cancer（P<0.001）. Moreover，as compared to the detection of TAP or CK19 alone，the combination of TAP and CK19 had a greater diagnostic value for bladder cancer. Conclusion TAP and CK19 were highly expressed in the serum of bladder cancer patients and may be considered as tumor markers for the diagnosis of bladder cancer. In addition，the detection of the combination of TAP and CK19 could improve the efficiency of diagnosis of bladder cancer.
Key words: bladder cancer, tumor abnormal protein, cytokeratin
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