78例非全身型幼年特发性关节炎临床特点分析
王兴伟1, 王秀丽1, 赵成广1, 于书源2, 杜悦11. 中国医科大学附属盛京医院小儿肾脏风湿免疫科, 沈阳 110004;
2. 东北大学医学与生物信息工程学院生物医学工程系, 沈阳 110819
收稿日期:
2022-05-09出版日期:
2023-05-30发布日期:
2023-05-26通讯作者:
杜悦E-mail:duy@sj-hospital.org作者简介:
王兴伟 (1995-),女,医师,硕士研究生.基金资助:
辽宁省民生科技计划联合计划(2021JH2/1030115)关键词: 幼年特发性关节炎, 生物制剂, 临床特点
Abstract: Objective To analyze the clinical characteristics of 78 children with non-systemic juvenile idiopathic arthritis (JIA),to provide more evidence for the diagnosis and treatment of JIA. Methods The clinical characteristics of 78 children newly diagnosed with non-systemic JIA hospitalized at the Department of Rheumatology,Shengjing Hospital of China Medical University,from January 2013 to January 2020,were analyzed considering the aspects of general situation,laboratory examination and treatment. Results The male-to-female ratio was 0.66:1 among the 78 patients 10 patients with oligarticular JIA,45 patients with polyarticular JIA,and 23 patients with arthritis associated to attachment inflammation. The incidence of JIA in children with oligarticular JIA occurred mostly in early childhood,and the inflammatory indexes (CRP and ESR) were not significantly increased. Multiarticular JIA mostly occurs in early school age and school age,and arthritis associated with attachment inflammation mostly occurs in early youth and adolescence. Inflammatory indexes of both JIA and JIA were significantly increased,and JIA may be accompanied with anemia. Most (59.0%) of the joint symptoms were joint mobility disorders,followed by joint swelling (33.3%). Joint effusion (71.8%),synovial hyperplasia (79.5%),and bone destruction (30.8%) were the common imaging findings. Fifty-five children (70.5%) were treated with biologics at the time of initial diagnosis. Children with multiarticular JIA and arthritis associated with attachment inflammation were treated with biologics in a shorter time than those without biologics (P< 0.05). Conclusion Differences in general conditions,joint symptoms,and inflammatory indicators were noted among different types of children with JIA. The application of biological agents can shorten the recovery time of joint movement disorders in some children.
Key words: juvenile idiopathic arthritis, biological agent, clinical feature
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