摘要： 血管生成参与维持正常的生理过程。糖尿病视网膜病变、类风湿性关节炎和癌症等多种疾病的发病机制均与血管生成失衡有关。血管生成刺激物和抑制物的共同作用，使血管生成保持平衡。此外，越来越多的证据表明，非编码RNA，特别是长链非编码RNA （lncRNA） 和微RNA （miRNA） 在血管生成的调控中发挥着重要作用。近年来，大量研究发现，lncRNA可能作为内源性海绵调节miRNA的表达和功能，miRNA与lncRNA结合的同时也可以调节其稳定性。本文对与血管生成发生发展相关的lncRNA进行综述，并讨论其潜在的作用机制和联系。

长链非编码RNA与微RNA相互作用在血管生成中的研究进展

陈欣欣, 陈晓隆

中国医科大学附属盛京医院眼科, 沈阳 110004

收稿日期:2022-03-01出版日期:2023-05-30发布日期:2023-05-26
通讯作者:陈晓隆E-mail:chenxl@sj-hospital.org
作者简介:陈欣欣 (1997-),女,硕士研究生.
基金资助:国家自然科学基金(81570866)


关键词: 血管生成, 长链非编码RNA, 微RNA, 血管疾病
Abstract: Angiogenesis maintains normal physiological processes,such as embryonic development,wound healing,inflammation,and reproduction. The pathogenesis of many diseases such as diabetic retinopathy,rheumatoid arthritis,and cancer is related to the imbalance of angiogenesis. Angiogenesis stimuli and inhibitors collaborate to maintain the angiogenesis balance. In addition,increasing evidence has shown that non-coding RNA,especially long non-coding RNA (lncRNA) and microRNAs (miRNA),are crucial in regulating angiogenesis. In recent years,numerous studies have found that lncRNA may act as an endogenous sponge to regulate the expression and function of miRNA and then combine with lncRNA to regulate its stability. Based on previous studies,this paper will review several types of lncRNA related to the occurrence and development of angiogenesis and discuss their potential mechanisms and relationships. Generally,the review will increase our knowledge of lncRNA and provide directions for future research related to angiogenesis.
Key words: angiogenesis, long non-coding RNA, microRNA, vascular disease
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