摘要： 核斑点旁组装转录1（NEAT1）是近年来发现的一种新型长链非编码RNA （lncRNA），由多发性内分泌肿瘤Ⅰ型转录位点转录生成。NEAT1可通过参与调节肿瘤细胞生长、迁移、侵袭、转移等，驱动肿瘤的发生和发展，是新型的诊断生物标志物和治疗靶标。本文对NEAT1在妇产科疾病中的研究进展进行综述，系统分析NEAT1在妇产科疾病发生发展中的作用机制，以期为妇产科疾病的病因机制研究及靶向治疗提供新的思路。

长链非编码RNA NEAT1在妇产科疾病中的研究进展

李海英^1,2, 吴涛³, 乔宠¹

1. 中国医科大学附属盛京医院妇产科, 沈阳 110004;
2. 大连市妇女儿童医疗中心(集团) 妇产科, 辽宁 大连 116000;
3. 大连医科大学附属第一医院麻醉科, 辽宁 大连 116000

收稿日期:2023-02-09出版日期:2023-04-30发布日期:2023-04-15
通讯作者:乔宠E-mail:cmulee@163.com
作者简介:李海英(1977-),女,主任医师,博士.
基金资助:国家自然科学基金（81370735）


关键词: 长链非编码RNA, 核斑点旁组装转录1, 妇产科疾病, 基因表达调控
Abstract: Nuclear paraspeckle assembly transcript 1 (NEAT1) is a recently discovered long non-coding RNA (lncRNA) that is transcribed from multiple endocrine tumor typeⅠtranscriptional sites. NEAT1 has been found to be involved in regulating the growth, migration, invasion, and metastasis of tumor cells to drive the occurrence and development of tumors. It plays an important role in the pathogenesis of many diseases, especially malignant tumors, and is a novel diagnostic biomarker and therapeutic target. This article reviews the progress of research into NEAT1 in gynecology and obstetrics diseases, systematically analyzing the role of NEAT1 in disease occurrence and development, in order to provide new directions for pathogenesis research and potential therapeutic targets for diseases in gynecology and obstetrics.
Key words: long non-coding RNA, NEAT1, obstetrics and gynecology diseases, gene expression regulation
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