摘要： 目的 探讨D-二聚体水平与颈内动脉取栓术后早期动脉再闭塞的相关性。方法 回顾性分析采用血管内取栓治疗实现颈内动脉有效再灌注的449例急性颈内动脉闭塞患者的临床资料，应用单因素和多因素logistic回归和曲线拟合分析术后D-二聚体水平与颈内动脉取栓术后早期（48 h）动脉再闭塞的相关性，分层分析术后D-二聚体水平在不同人口学特征和疾病条件下与颈内动脉取栓术后早期动脉再闭塞是否仍有相关性。结果 449例行取栓术的急性颈内动脉闭塞患者中，56例（12.5%）发生早期动脉再闭塞。多因素logistic回归分析显示，随着术后D-二聚体水平升高，颈内动脉取栓术后早期动脉再闭塞风险增加（OR=1.03，95% CI：1.01~1.04，P<0.0001）。曲线拟合结果显示，随着D-二聚体水平升高，颈内动脉取栓术后早期动脉再闭塞风险增加，呈非线性关系。分层分析结果显示，不同人口学特征和疾病条件下，D-二聚体水平升高与颈内动脉取栓术后早期动脉再闭塞风险增加密切相关。结论 D-二聚体水平升高与颈内动脉取栓术后早期动脉再闭塞风险密切相关。

D-二聚体水平与颈内动脉取栓术后早期动脉再闭塞的相关性

宋莉, 宋凯, 曹冬日

中国医科大学附属盛京医院神经外科, 沈阳 110004

收稿日期:2022-06-29出版日期:2023-03-30发布日期:2023-03-21
通讯作者:宋莉E-mail:songli18940252515@163.com
作者简介:宋莉(1989-),女,护师,本科.



关键词: D-二聚体, 颈内动脉闭塞, 取栓, 早期动脉再闭塞, 相关性
Abstract: Objective To investigate the association between D-dimer level and early arterial reocclusion after internal carotid artery thrombectomy. Methods The clinical data of patients with acute internal carotid artery occlusion in whom reperfusion of the internal carotid artery was achieved using endovascular thrombectomy were retrospectively reviewed. The association between postoperative D-dimer level and early （48 h） arterial reocclusion after internal carotid artery thrombectomy was analyzed by applying univariate and multivariate logistic regression and curve fitting. The consistency of the association between postoperative D-dimer level and early arterial reocclusion after internal carotid artery thrombectomy was investigated by stratified analyses. Results Among 449 patients with acute internal carotid artery occlusion who underwent internal carotid artery thrombectomy，56 （12.47%） experienced early arterial reocclusion. Multivariate logistic regression analysis showed that the risk of early arterial reocclusion after internal carotid artery thrombectomy increased with increasing D-dimer level （odds ratio，1.03； 95% confidence interval，1.01-1.04； P<0.0001）. Curve fitting revealed an increased risk of early arterial reocclusion after internal carotid artery thrombectomy with increasing D-dimer level，and nonlinear relationship was observed. Stratified analyses revealed an increased risk of early arterial reocclusion after internal carotid artery thrombectomy with increasing D-dimer level across different demographic characteristics and disease conditions. Conclusion Increased D-dimer level is associated with the risk of early arterial reocclusion after internal carotid artery thrombectomy.
Key words: D-dimer, internal carotid artery occlusion, thrombectomy, early arterial reocclusion, association
PDF全文下载地址:

https://journal.cmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=3181